N-Acetylcysteine for the Treatment of Clove Oil-Induced Fulminant Hepatic Failure

Journal of Toxicology - Clinical Toxicology

Volumn 42, Issue 1, 2004, Pages 89-92

  Eisen, Jeffrey S ^a,d,e   Koren, Gideon ^b,c,d   Juurlink, David N ^c,d   Ng, Vicky L ^b,d  

^a QUEEN S UNIVERSITY   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e KINGSTON GENERAL HOSPITAL   (Canada)

Author keywords

Acetylcysteine; Eugenol; Liver failure; Poisoning

Indexed keywords

ACETYLCYSTEINE; CLOVE OIL;

CASE REPORT; CLINICAL EXAMINATION; CLINICAL FEATURE; CONSERVATIVE TREATMENT; DISEASE COURSE; ENDOTRACHEAL INTUBATION; FEMALE; HOSPITAL ADMISSION; HUMAN; INFANT; LIVER FAILURE; LIVER FUNCTION; REVIEW; TREATMENT OUTCOME;

ACETYLCYSTEINE; ANTIDOTES; CLOVE OIL; DECONTAMINATION; FEMALE; FREE RADICAL SCAVENGERS; HUMANS; INFANT; LIVER FAILURE; TREATMENT OUTCOME;

SYZYGIUM AROMATICUM;

EID: 1842428952     PISSN: 07313810     EISSN: None     Source Type: Journal    
DOI: 10.1081/CLT-120028751     Document Type: Review

References (17)

1. Makin AJ, Wendon J, Williams R. A seven year experience of severe acetaminophen-induced hepatotoxicity (1987-1993). Gastroenterology 1995; 109:1907-1916.
2. Sanchez-Perez J, Garcia-Diez A. Occupational allergic contact dermatitis from eugenol, oil of cinnamon and oil of cloves in a physiotherapist. Contact Dermatitis 1999; 41(6):346-347.
3. Ojeda LS, Torres TE, Navarro CC. Iatrogenic disease in pediatric dentistry: report of a case. Pract Odontol 1991; 12(8):25-27.
4. Vilaplana J, Grimalt F, Romaguera C, Conellana F. Contact dermatitis from eugenol in mouthwash. Contact Dermatitis 1991; 24(3):223-224.
5. Isaacs G. Permanent local anaesthesia and anhidrosis after clove oil spillage. Lancet 1983; 1(8329):882.
6. Grade AC, Martens BP. Chronic urticaria due to dental eugenol. Dermatologica 1989; 178(4):217-220.
7. Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg Oral Med Oral Pathol 1984; 57(4):441-442.
8. Hartnoll G, Moore D, Douek D. Near fatal ingestion of oil of cloves. Arch Dis Child 1993; 69(3):392-393.
9. Brown SA, Biggerstaff J, Savidge GF. Disseminated intravascular coagulation and hepatocellular necrosis due to clove oil. Blood Coagul Fibrinolysis 1992; 3(5):665-668.
10. Lane BW, Ellenhorn MJ, Hulbert TV, McCarron M. Clove oil ingestion in an infant. Human Exp Toxicol 1991; 10(4):291-294.
11. Kirsch CM, Yenokida GG, Jensen WA, Wendland R, Suh H, Bourgault M. Non-cardiogenic pulmonary oedema due to the intravenous administration of clove oil. Thorax 1990; 45(3):235-236.
12. Thompson DC, Constantin-Teodosiu D, Egestad B, Mickos H, Moldeus P. Formation of glutathione conjugates during oxidation of eugenol by microsomal fractions of rat liver and lung. Biochem Pharmacol 1990; 39(10):1587-1595.
13. Mizutani T, Satoh K, Nomura H, Nakanishi K. Hepatotoxicity of eugenol in mice depleted of glutathione by treatment with DL-buthionine sulfoximine. Res Commun Chem Pathol Pharmacol 1991; 71(2):219-230.
14. Thompson DC, Barhoumi R, Burghardt RC. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol 1998; 149(1):55-63.
15. Thompson DC, Constantin-Teodosiu D, Moldeus P. Metabolism and cytotoxicity of eugenol in isolated rat hepatocytes. Chem-Biol Interact 1991; 77(2):137-147.
16. Keays R, Harrison PM, Wendon JA, Forbes A, Gove C, Alexander GJ, Williams R. Intravenous acetylcysteine in paracetamol induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991; 303:1026-1029.
17. Wendon JA, Harrison PM, Keays R, Williams R. Cerebral blood flow and metabolism in fulminant liver failure. Hepatology 1994; 19(6):1407-1413.