-
1
-
-
0034827655
-
Bleomycin-induced pneumonitis
-
Sleijfer S. Bleomycin-induced pneumonitis. Chest. 120:2001;617-624.
-
(2001)
Chest
, vol.120
, pp. 617-624
-
-
Sleijfer, S.1
-
2
-
-
11544259897
-
Cleavage of nucleic acids by bleomycin
-
Burger R.M. Cleavage of nucleic acids by bleomycin. Chem Rev. 98:1998;1153-1169.
-
(1998)
Chem Rev
, vol.98
, pp. 1153-1169
-
-
Burger, R.M.1
-
3
-
-
0033558171
-
Bleomycin: Synthetic and mechanistic studies
-
Boger D.L., Cai H. Bleomycin: synthetic and mechanistic studies. Angew Chem Int Ed Engl. 38:1999;449-476.
-
(1999)
Angew Chem Int Ed Engl
, vol.38
, pp. 449-476
-
-
Boger, D.L.1
Cai, H.2
-
4
-
-
0000357885
-
Nucleic acid recognition by metal complexes of bleomycin
-
Claussen C.A., Long E.C. Nucleic acid recognition by metal complexes of bleomycin. Chem Rev. 99:1999;2797-2816.
-
(1999)
Chem Rev
, vol.99
, pp. 2797-2816
-
-
Claussen, C.A.1
Long, E.C.2
-
5
-
-
0030591651
-
DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: Bleomycin, neocarzinostatin and other enediynes
-
Povirk L.F. DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes. Mutat Res. 355:1996;71-89.
-
(1996)
Mutat Res
, vol.355
, pp. 71-89
-
-
Povirk, L.F.1
-
6
-
-
0037259429
-
RNA cleavage and inhibition of protein synthesis by bleomycin
-
BLM can cleave selected members of rRNA, mRNA and tRNA. This paper demonstrates the correlation of protein synthesis inhibition with RNA cleavage, suggesting a new mode of cytotoxicity.
-
Abraham A.T., Lin J.J., Newton D.L., Rybak S., Hecht S.M. RNA cleavage and inhibition of protein synthesis by bleomycin. Chem Biol. 10:2003;45-52 BLM can cleave selected members of rRNA, mRNA and tRNA. This paper demonstrates the correlation of protein synthesis inhibition with RNA cleavage, suggesting a new mode of cytotoxicity.
-
(2003)
Chem Biol
, vol.10
, pp. 45-52
-
-
Abraham, A.T.1
Lin, J.J.2
Newton, D.L.3
Rybak, S.4
Hecht, S.M.5
-
7
-
-
0037018482
-
Deglycobleomycin: Solid-phase synthesis and DNA cleavage by the resin-bound ligand
-
Smith K.L., Tao Z.F., Hashimoto S., Leitheiser C.J., Wu X., Hecht S.M. Deglycobleomycin: solid-phase synthesis and DNA cleavage by the resin-bound ligand. Org Lett. 4:2002;1079-1082.
-
(2002)
Org Lett
, vol.4
, pp. 1079-1082
-
-
Smith, K.L.1
Tao, Z.F.2
Hashimoto, S.3
Leitheiser, C.J.4
Wu, X.5
Hecht, S.M.6
-
8
-
-
0033980083
-
Bleomycin: New perspectives on the mechanism of action
-
Hecht S.M. Bleomycin: new perspectives on the mechanism of action. J Nat Prod. 63:2000;158-168.
-
(2000)
J Nat Prod
, vol.63
, pp. 158-168
-
-
Hecht, S.M.1
-
9
-
-
0037032261
-
Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: Exploring the role of the carbohydrate moiety in RNA cleavage
-
Thomas C.J., Chizhov A.O., Leitheiser C.J., Rishel M.J., Konishi K., Tao Z.F., Hecht S.M. Solid-phase synthesis of bleomycin A(5) and three monosaccharide analogues: exploring the role of the carbohydrate moiety in RNA cleavage. J Am Chem Soc. 124:2002;12926-12927.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 12926-12927
-
-
Thomas, C.J.1
Chizhov, A.O.2
Leitheiser, C.J.3
Rishel, M.J.4
Konishi, K.5
Tao, Z.F.6
Hecht, S.M.7
-
10
-
-
0002746148
-
Bleomycins: A structural model for specificity, binding, and double strand cleavage
-
Stubbe J., Kozarich J.W., Wu W., Vanderwall D.E. Bleomycins: A structural model for specificity, binding, and double strand cleavage. Acc Chem Res. 29:1996;322-330.
-
(1996)
Acc Chem Res
, vol.29
, pp. 322-330
-
-
Stubbe, J.1
Kozarich, J.W.2
Wu, W.3
Vanderwall, D.E.4
-
11
-
-
0032538002
-
A systematic evaluation of the bleomycin A(2) L-threonine side chain: Its role in preorganization of a compact conformation implicated in sequence-selective DNA cleavage
-
Boger D.L., Ramsey T.M., Cai H., Hoehn S.T., Stubbe J.A. A systematic evaluation of the bleomycin A(2) L-threonine side chain: Its role in preorganization of a compact conformation implicated in sequence-selective DNA cleavage. J Am Chem Soc. 120:1998;9139-9148.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 9139-9148
-
-
Boger, D.L.1
Ramsey, T.M.2
Cai, H.3
Hoehn, S.T.4
Stubbe, J.A.5
-
12
-
-
0032538003
-
Definition of the effect and role of the bleomycin A(2) valerate substituents: Preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage
-
Boger D.L., Ramsey T.M., Cai H., Hoehn S.T., Stubbe J. Definition of the effect and role of the bleomycin A(2) valerate substituents: preorganization of a rigid, compact conformation implicated in sequence-selective DNA cleavage. J Am Chem Soc. 120:1998;9149-9158.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 9149-9158
-
-
Boger, D.L.1
Ramsey, T.M.2
Cai, H.3
Hoehn, S.T.4
Stubbe, J.5
-
13
-
-
0033835373
-
The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase
-
The discovery of the long-sought genes for the biosynthesis of BLM offers new opportunities for investigation of the role of the carbohydrate moiety of BLMs.
-
Du L., Sanchez C., Chen M., Edwards D.J., Shen B. The biosynthetic gene cluster for the antitumor drug bleomycin from Streptomyces verticillus ATCC15003 supporting functional interactions between nonribosomal peptide synthetases and a polyketide synthase. Chem Biol. 7:2000;623-642 The discovery of the long-sought genes for the biosynthesis of BLM offers new opportunities for investigation of the role of the carbohydrate moiety of BLMs.
-
(2000)
Chem Biol
, vol.7
, pp. 623-642
-
-
Du, L.1
Sanchez, C.2
Chen, M.3
Edwards, D.J.4
Shen, B.5
-
14
-
-
0030956956
-
1H-tetrazole as catalyst in phosphomorpholidate coupling reactions: Efficient synthesis of GDP-fucose, GDP-mannose, and UDP-galactose
-
Wittmann V., Wong C.H. 1H-tetrazole as catalyst in phosphomorpholidate coupling reactions: efficient synthesis of GDP-fucose, GDP-mannose, and UDP-galactose. J Org Chem. 62:1997;2144-2147.
-
(1997)
J Org Chem
, vol.62
, pp. 2144-2147
-
-
Wittmann, V.1
Wong, C.H.2
-
15
-
-
0037109032
-
Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering
-
Barton W.A., Biggins J.B., Jiang J., Thorson J.S., Nikolov D.B. Expanding pyrimidine diphosphosugar libraries via structure-based nucleotidylyltransferase engineering. Proc Natl Acad Sci USA. 99:2002;13397-13402.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13397-13402
-
-
Barton, W.A.1
Biggins, J.B.2
Jiang, J.3
Thorson, J.S.4
Nikolov, D.B.5
-
16
-
-
0035004439
-
Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization
-
Barton W.A., Lesniak J., Biggins J.B., Jeffrey P.D., Jiang J., Rajashankar K.R., Thorson J.S., Nikolov D.B. Structure, mechanism and engineering of a nucleotidylyltransferase as a first step toward glycorandomization. Nat Struct Biol. 8:2001;545-551.
-
(2001)
Nat Struct Biol
, vol.8
, pp. 545-551
-
-
Barton, W.A.1
Lesniak, J.2
Biggins, J.B.3
Jeffrey, P.D.4
Jiang, J.5
Rajashankar, K.R.6
Thorson, J.S.7
Nikolov, D.B.8
-
17
-
-
0025250121
-
The role of redox-active metals in the mechanism of action of bleomycin
-
Petering D.H., Byrnes R.W., Antholine W.E. The role of redox-active metals in the mechanism of action of bleomycin. Chem Biol Interact. 73:1990;133-182.
-
(1990)
Chem Biol Interact
, vol.73
, pp. 133-182
-
-
Petering, D.H.1
Byrnes, R.W.2
Antholine, W.E.3
-
18
-
-
0038390597
-
15N] HSQC NMR investigation of bleomycin, deglycobleomycin, and their hydroperoxide-cobalt(III) complexes
-
3+-OOH, negating interpretation of earlier studies on Co(III)-pepleomycin [39].
-
3+-OOH, negating interpretation of earlier studies on Co(III)-pepleomycin [39].
-
(2003)
Biochemistry
, vol.42
, pp. 6559-6564
-
-
Xia, C.1
Forsterling, F.H.2
Petering, D.H.3
-
20
-
-
0042233838
-
Spectroscopic studies of the interaction of ferrous bleomycin with DNA
-
Kemsley J.N., Zaleski K.L., Chow M.S., Decker A., Shishova E.Y., Wasinger E.C., Hedman B., Hodgson K.O., Solomon E.I. Spectroscopic studies of the interaction of ferrous bleomycin with DNA. J Am Chem Soc. 125:2003;10810-10821.
-
(2003)
J Am Chem Soc
, vol.125
, pp. 10810-10821
-
-
Kemsley, J.N.1
Zaleski, K.L.2
Chow, M.S.3
Decker, A.4
Shishova, E.Y.5
Wasinger, E.C.6
Hedman, B.7
Hodgson, K.O.8
Solomon, E.I.9
-
21
-
-
0036933220
-
Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: Are the Co(II) and Fe(II) adducts isostructural?
-
Lehmann T.E. Molecular modeling of the three-dimensional structure of Fe(II)-bleomycin: are the Co(II) and Fe(II) adducts isostructural? J Biol Inorg Chem. 7:2002;305-312.
-
(2002)
J Biol Inorg Chem
, vol.7
, pp. 305-312
-
-
Lehmann, T.E.1
-
23
-
-
0030981907
-
Fe- and Co-bleomycins bound to site specific and nonspecific DNA decamers: Comparative binding and reactivity of their metal centers
-
Fulmer P., Zhao C., Li W., DeRose E., Antholine W.E., Petering D.H. Fe- and Co-bleomycins bound to site specific and nonspecific DNA decamers: comparative binding and reactivity of their metal centers. Biochemistry. 36:1997;4367-4374.
-
(1997)
Biochemistry
, vol.36
, pp. 4367-4374
-
-
Fulmer, P.1
Zhao, C.2
Li, W.3
Derose, E.4
Antholine, W.E.5
Petering, D.H.6
-
24
-
-
0032542563
-
Spectroscopic investigation of the metal ligation and reactivity of the ferrous active sites of bleomycin and bleomycin derivatives
-
Loeb K.E., Zaleski J.M., Hess C.D., Hecht S.M., Solomon E.I. Spectroscopic investigation of the metal ligation and reactivity of the ferrous active sites of bleomycin and bleomycin derivatives. J Am Chem Soc. 120:1998;1249-1259.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 1249-1259
-
-
Loeb, K.E.1
Zaleski, J.M.2
Hess, C.D.3
Hecht, S.M.4
Solomon, E.I.5
-
25
-
-
0023141849
-
Copper- dependent cleavage of DNA by bleomycin
-
Ehrenfeld G.M., Shipley J.B., Heimbrook D.C., Sugiyama H., Long E.C., van Boom J.H., van der Marel G.A., Oppenheimer N.J., Hecht S.M. Copper- dependent cleavage of DNA by bleomycin. Biochemistry. 26:1987;931-942.
-
(1987)
Biochemistry
, vol.26
, pp. 931-942
-
-
Ehrenfeld, G.M.1
Shipley, J.B.2
Heimbrook, D.C.3
Sugiyama, H.4
Long, E.C.5
Van Boom, J.H.6
Van Der Marel, G.A.7
Oppenheimer, N.J.8
Hecht, S.M.9
-
26
-
-
0034731019
-
Electronic structure of activated bleomycin: Oxygen intermediates in heme versus non-heme iron
-
Neese F., Zaleski J.M., Zaleski K.L., Solomon E.I. Electronic structure of activated bleomycin: oxygen intermediates in heme versus non-heme iron. J Am Chem Soc. 122:2000;11703-11724.
-
(2000)
J Am Chem Soc
, vol.122
, pp. 11703-11724
-
-
Neese, F.1
Zaleski, J.M.2
Zaleski, K.L.3
Solomon, E.I.4
-
27
-
-
0037063569
-
Electronic structure and reactivity of low-spin Fe(III)-hydroperoxo complexes: Comparison to activated bleomycin
-
Calculations in an effort to guide thinking about the reactivity of low spin non-heme iron peroxides.
-
Lehnert N., Neese F., Ho R.Y., Que L. Jr., Solomon E.I. Electronic structure and reactivity of low-spin Fe(III)-hydroperoxo complexes: comparison to activated bleomycin. J Am Chem Soc. 124:2002;10810-10822 Calculations in an effort to guide thinking about the reactivity of low spin non-heme iron peroxides.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 10810-10822
-
-
Lehnert, N.1
Neese, F.2
Ho, R.Y.3
Que, L.Jr.4
Solomon, E.I.5
-
28
-
-
0027503248
-
Isotope effects on the cleavage of DNA by bleomycin: Mechanism and modulation
-
Worth L. Jr., Frank B.L., Christner D.F., Absalon M.J., Stubbe J., Kozarich J.W. Isotope effects on the cleavage of DNA by bleomycin: mechanism and modulation. Biochemistry. 32:1993;2601-2609.
-
(1993)
Biochemistry
, vol.32
, pp. 2601-2609
-
-
Worth, L.Jr.1
Frank, B.L.2
Christner, D.F.3
Absalon, M.J.4
Stubbe, J.5
Kozarich, J.W.6
-
29
-
-
0038747011
-
The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: A high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli
-
Price J.C., Barr E.W., Tirupati B., Bollinger J.M. Jr., Krebs C. The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli. Biochemistry. 42:2003;7497-7508.
-
(2003)
Biochemistry
, vol.42
, pp. 7497-7508
-
-
Price, J.C.1
Barr, E.W.2
Tirupati, B.3
Bollinger, J.M.Jr.4
Krebs, C.5
-
30
-
-
0035850519
-
2. Efficient, double-strand DNA cleavage accessible without structural reorganization
-
2. Efficient, double-strand DNA cleavage accessible without structural reorganization. J Am Chem Soc. 123:2001;8690-8700.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 8690-8700
-
-
Keck, M.V.1
Manderville, R.A.2
Hecht, S.M.3
-
31
-
-
0035918531
-
Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: Implications for bleomycin-induced double-strand DNA cleavage
-
Hoehn S.T., Junker H.D., Bunt R.C., Turner C.J., Stubbe J. Solution structure of Co(III)-bleomycin-OOH bound to a phosphoglycolate lesion containing oligonucleotide: implications for bleomycin-induced double-strand DNA cleavage. Biochemistry. 40:2001;5894-5905.
-
(2001)
Biochemistry
, vol.40
, pp. 5894-5905
-
-
Hoehn, S.T.1
Junker, H.D.2
Bunt, R.C.3
Turner, C.J.4
Stubbe, J.5
-
32
-
-
0032486797
-
Characterization of Zn(II)-deglycobleomycin A(2) and interaction with d(CGCTAGCG)(2): Direct evidence for minor groove binding of the bithiazole moiety
-
Sucheck S.J., Ellena J.F., Hecht S.M. Characterization of Zn(II)-deglycobleomycin A(2) and interaction with d(CGCTAGCG)(2): direct evidence for minor groove binding of the bithiazole moiety. J Am Chem Soc. 120:1998;7450-7460.
-
(1998)
J Am Chem Soc
, vol.120
, pp. 7450-7460
-
-
Sucheck, S.J.1
Ellena, J.F.2
Hecht, S.M.3
-
33
-
-
0034801244
-
Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism
-
Abraham A.T., Zhou X., Hecht S.M. Metallobleomycin-mediated cleavage of DNA not involving a threading-intercalation mechanism. J Am Chem Soc. 123:2001;5167-5175.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 5167-5175
-
-
Abraham, A.T.1
Zhou, X.2
Hecht, S.M.3
-
34
-
-
18744398387
-
2: Evidence for binding by partial intercalation
-
This article demonstrates that phleomycin (PLM) binds by partial intercalation, despite the fact that the penultimate thiazolium ring is partially reduced. Thus, the observation that PLM and BLM cleave DNA in vivo with similar efficiency does not negate the importance of the intercalative mode of binding of BLMs.
-
2: evidence for binding by partial intercalation. Nucleic Acids Res. 30:2002;4881-4891 This article demonstrates that phleomycin (PLM) binds by partial intercalation, despite the fact that the penultimate thiazolium ring is partially reduced. Thus, the observation that PLM and BLM cleave DNA in vivo with similar efficiency does not negate the importance of the intercalative mode of binding of BLMs.
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 4881-4891
-
-
Wu, W.1
Vanderwall, D.E.2
Turner, C.J.3
Hoehn, S.4
Chen, J.5
Kozarich, J.W.6
Stubbe, J.7
-
35
-
-
0035799885
-
Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate
-
Choudhury A.K., Tao Z.F., Hecht S.M. Synthesis and DNA cleavage activity of a novel bleomycin A(5) glycoconjugate. Org Lett. 3:2001;1291-1294.
-
(2001)
Org Lett
, vol.3
, pp. 1291-1294
-
-
Choudhury, A.K.1
Tao, Z.F.2
Hecht, S.M.3
-
36
-
-
0028923387
-
Sequence-specific double-strand cleavage of DNA by Fe bleomycin. 2. Mechanism and dynamics
-
Absalon M.J., Wu W., Kozarich J.W., Stubbe J. Sequence-specific double-strand cleavage of DNA by Fe bleomycin. 2. Mechanism and dynamics. Biochemistry. 34:1995;2076-2086.
-
(1995)
Biochemistry
, vol.34
, pp. 2076-2086
-
-
Absalon, M.J.1
Wu, W.2
Kozarich, J.W.3
Stubbe, J.4
-
37
-
-
0036913910
-
Remarkable structural similarities between diverse glycosyltransferases
-
Hu Y., Walker S. Remarkable structural similarities between diverse glycosyltransferases. Chem Biol. 9:2002;1287-1296.
-
(2002)
Chem Biol
, vol.9
, pp. 1287-1296
-
-
Hu, Y.1
Walker, S.2
-
38
-
-
12244297801
-
Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides
-
Losey H.C., Jiang J., Biggins J.B., Oberthur M., Ye X.Y., Dong S.D., Kahne D., Thorson J.S., Walsh C.T. Incorporation of glucose analogs by GtfE and GtfD from the vancomycin biosynthetic pathway to generate variant glycopeptides. Chem Biol. 9:2002;1305-1314.
-
(2002)
Chem Biol
, vol.9
, pp. 1305-1314
-
-
Losey, H.C.1
Jiang, J.2
Biggins, J.B.3
Oberthur, M.4
Ye, X.Y.5
Dong, S.D.6
Kahne, D.7
Thorson, J.S.8
Walsh, C.T.9
-
39
-
-
0030934164
-
Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green forms) determined by NMR studies
-
Caceres-Cortes J., Sugiyama H., Ikudome K., Saito I., Wang A.H. Structures of cobalt(III)-pepleomycin and cobalt(III)-deglycopepleomycin (green forms) determined by NMR studies. Eur J Biochem. 244:1997;818-828.
-
(1997)
Eur J Biochem
, vol.244
, pp. 818-828
-
-
Caceres-Cortes, J.1
Sugiyama, H.2
Ikudome, K.3
Saito, I.4
Wang, A.H.5
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