The effect of haemodilution on antithrombin concentration during cardiac surgery

Anaesthesia and Intensive Care

Volumn 32, Issue 2, 2004, Pages 219-223

  Linden, M D ^b,e   Gibbs, N M ^a   Bremner, M ^a   Schneider, M ^d   Erber, W N ^c  

^a SIR CHARLES GAIRDNER HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c Western Australian Centre for Pathology and Medical Research   (Australia)

^d Mount Hospital   (Australia)

^e UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Antithrombin; Cardiac surgery; Cardiopulmonary bypass; Haemodilution; Haemoglobin

Indexed keywords

ANTITHROMBIN; HEMOGLOBIN;

ADULT; AGED; ARTICLE; CARDIOPULMONARY BYPASS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORRELATION COEFFICIENT; ELECTIVE SURGERY; FEMALE; HEART SURGERY; HEMODILUTION; HEMOGLOBIN DETERMINATION; HUMAN; MAJOR CLINICAL STUDY; MALE; REFERENCE VALUE;

EID: 1842419470     PISSN: 0310057X     EISSN: None     Source Type: Journal    
DOI: 10.1177/0310057x0403200209     Document Type: Article

References (27)

1. British Pharmacopoeia Commission. British Approved Names 2002: The Stationery Office; 2001.
2. Rosenberg RD, Damus PS. The purification and mechanism of action of human antithrombin-heparin cofactor. J Biol Chem 1973; 248:6490-6505.
3. Murano G, Williams L, Miller-Anderson M, Aronson DL, King C. Some properties of antithrombin III and its concentration in human plasma. Thromb Haemostas 1980; 18:259-262.
4. Jin L, Abrahams JP, Skinner R, Petitou M, Pike RN, Carrell RW. The anticoagulant activation of antithrombin by heparin. Proc Nat Acad Sci USA 1997; 94:14683-14688.
5. Olson ST, Bock PE, Kvassman J et al. Role of catalytic serine in the interactions of serine proteases with protein inhibitors of the serpin family: Contribution of a covalent interaction to the binding energy of serpin-proteinase complexes. J Biol Chem 1995; 270:30007-30017.
6. Salzet M, Vieau D, Stefano GB. Serpins: An evolutionarily conserved survival strategy. Immunol Today 1999; 20:541-544.
7. Lindahl U, Backstrom G, Hook M, Thunberg L, Fransson LA, Linker A. Structure of the antithrombin binding site in heparin. Proc Nat Acad Sci USA 1979; 76:3198-3202.
8. Lindahl U, Backstrom G, Thunberg L, Leder IG. Evidence for a 3-O-sulfated D-glucosamine residue in the antithrombin-binding sequence of heparin. Proc Nat Acad Sci USA 1980; 77:6551-6555.
9. Choay J, Petitou M, Lormeau JC, Sinay P, Casu B, Gatti G. Structure-activity relationship in heparin: A synthetic pentasaccharide with high affinity for antithrombin III and eliciting high anti-factor Xa activity. Biochem Biophys Res Comm 1983; 116:492-499.
10. Olson ST, Bjork I, Sheffer R, Craig PA, Shore JD, Choay J. Role of the antithrombin-binding pentasaccharide in heparin acceleration of antithrombin-proteinase reactions. Resolution of the antithrombin conformational change contribution to heparin rate enhancement. J Biol Chem 1992; 267:12528-12538.
11. Carlson TH, Simon TL, Atencio AC. In vivo behavior of human radioiodinated antithrombin III: Distribution among three physiologic pools. Blood 1985; 66:13-19.
12. Torry RJ, Labarrere CA, Nelson D, Pantaleo A, Faulk WP. Localization and characterization of antithrombin in human kidneys. J Histochem Cytochem 1999; 47:313-321.
13. Knot EAR, de Jong E, ten Cate JW, Gie LK, van Royen EA. Antithrombin III: Biodistribution in healthy volunteers. Thromb Haemostas 1987; 58:1008-1011.
14. Kongsgaard UE, Smith-Erichsen N, Geiran O, Bjornskau L. Changes in the coagulation and fibrinolytic systems during and after cardiopulmonary bypass surgery. Thorac Cardiovasc Surg 1989; 37:158-162.
15. Despotis GJ, Joist JH, Hogue CW, Jr et al. The impact of heparin concentration and activated clotting time monitoring on blood conservation. A prospective, randomized evaluation in patients undergoing cardiac operation. J Thorac Cardiovasc Surg 1995; 110:46-54.
16. Despotis GJ, Joist JH. Anticoagulation and anticoagulation reversal with cardiac surgery involving cardiopulmonary bypass: An update. J Cardiothorac Vasc Anesth 1999; 13:18-29.
17. Brister SJ, Ofosu EA, Buchanan MR. Thrombin generation during cardiac surgery: Is heparin the ideal anticoagulant? Thromb Haemostas 1993; 70:259-262.
18. Lardi AM, Hirst C, Mortimer AJ, McCollum CN. Evaluation of the HemoCue for measuring intra-operative haemoglobin concentration: A comparison with the Coulter Max-M. Anaesthesia 1998; 53:349-352.
19. Rosenblit J, Abreu CR, Szterling LN et al. Evaluation of three methods for hemoglobin measurement in a blood donor setting. Sao Paulo Med J 1999; 117:108-112.
20. von Schenck H, Falkensson M, Lundberg B. Evaluation of "HEmoCue", a new device for determinating hemoglobin. Clin Chem 1986; 32:526-529.
21. Dawson B, Trapp RG. Basic and clinical biostatistics. 3rd ed. Boston; Lange Medical Books/McGraw-Hill 2001.
22. Chen PP, Short TG, Leung DH, Oh TE. A clinical evaluation of the Hemocue haemoglobinometer using capillary, venous and arterial samples. Anaesth Intensive Care 1992; 20:497-500.
23. Casati V, Gerli C, Franco A et al. Activation of coagulation and fibrinolysis during coronary surgery: On-pump versus off-pump techniques. Anesthesiology 2001; 95:1103-1109.
24. Ng KFJ, Lam CCK, Chan LC. In vivo effect of haemodilution with saline on coagulation: A randomized controlled trial. Br J Anaesth 2002; 88:475-480.
25. Ruttmann TG. Editorial II: Haemodilution enhances coagulation. Br J Anaesth 2002; 88:470-472.
26. Levy JH, Despotis GJ, Szlam F, Olson P, Meeker D, Weisinger A. Recombinant human transgenic antithrombin in cardiac surgery: A dose-finding study. Anesthesiology 2002; 96:1095-1102.
27. Levy JH, Montes F, Szlam F, Hillyer CD. The in vitro effects of antithrombin III on the activated coagulation time in patients on heparin therapy. Anesth Analg 2000; 90:1076-1079.