Induction of protective immunity after Escherichia coli bladder infection in primates: Dependence of the globoside-specific P-fimbrial tip adhesin and its cognate receptor

Journal of Clinical Investigation

Volumn 100, Issue 2, 1997, Pages 364-372

  Söderhäll, Mats ^a   Normark, Staffan ^b,c   Ishikawa, Kiyohito ^b   Karlsson, K A ^d   Teneberg, Susann ^d   Winberg, Jan ^a   Möllby, Roland ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Bacterial adhesion; Globoside; Glycosphingolipids; Mucosal immunity; Urinary tract infections

Indexed keywords

ADHESIN;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIUM ADHERENCE; CYSTITIS; ESCHERICHIA COLI; FIMBRIA; GRAM NEGATIVE INFECTION; IMMUNE RESPONSE; NONHUMAN; PRIMATE; PRIORITY JOURNAL; RECTUM; VAGINA;

EID: 1842410785     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119542     Document Type: Article

References (42)

1. Hooton, T.M., D. Scholes, J.P. Hughes, C. Winter, P.L. Roberts, A.E. Stapleton, A. Stergachis, and W.E. Stamm. 1996. A prospective study of risk factors for symptomatic urinary tract infection in young women. N. Engl. J. Med. 335:468-474.
2. Ronald, A. Sex and urinary tract infections. 1996. N. Engl. J. Med. 335: 511-512.
3. Svanborg, C. 1993. Resistance to urinary tract infections. N. Engl. J. Med. 329:802-803.
4. Kunin, C.M. 1997. Detection, Prevention and Management of Urinary Tract Infections. 5th edition. Williams & Wilkins, Baltimore. 301-304.
5. Asscher, A.W. 1980. The Challenge of Urinary Tract Infections. Academic Press, London/Toronto/Sydney. Grune and Stratton, New York/San Francisco. 41-51.
6. Winberg, J., H.J. Andersen, T. Bergström, B. Jacohsson, H. Larson, and K. Lincoln. 1974. Epidemiology of symptomatic urinary tract infection in childhood. Acta Paediatr. Scand. 252 (Suppl.):1-20.
7. Lindberg, U., L.Å. Hanson, U. Jodal, G. Lidin-Janson, K. Lincoln, and S. Oiling. 1975. Differences in Escherichia coli causing asymptomatic and symptomatic bacteriuria. Acta Paediatr. Scand. 64:432-436.
8. Källenius, G., R. Möllby, S.B. Svensson, I. Helin, H. Hultberg, B. Cedergren, and J. Winberg. 1981. Occurrence of P-fimbriated Escherichia coli in urinary tract infections. Lancet. ii:1369-1372.
9. Väisänen, R., J. Elo, L.G. Tallgren, A. Siitonen, P.H. Siitonen, and C. Svanborg-Edén. 1981. Mannose resistant haemagglutination and P antigen recognition characteristics of E. coli causing primary pyelonephritis. Lancet. ii: 1366-1369.
10. Lidefeldt, K.J., I. Bollgren, G. Källenius, and S.B. Svenson. 1987. P-fimbriated Escherichia coli in children with acute cystitis. Acta Paediatr. Scand. 76: 775-780.
11. Kuehn, I., J. Heuser, S. Normark, and S. Hultgren. 1992. P-pili in uropathogenic E. coli are composite fibers with distinct fibrillar adhesive tips. Nature (Lond.). 356:252-255.
12. Lindberg, F., B. Lund, L. Johansson, and S. Normark. 1987. Localization of the receptor-binding protein adhesin at the tip of the bacterial pilus. Nature (Lond.). 328:84-87.
13. Lund, B., F. Lindberg, B.I. Marklund, and S. Normark. 1987. The papG protein is the Galα(1-4)Gal binding adhesin in uropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA. 84:5898-5902.
14. Johanson, I.-M., K. Plos, B.I. Marklund, and C. Svanborg. 1993. Pap, papG and prsG DNA sequences in Escherichia coli from the fecal flora and the urinary tract. Microb. Pathog. 15:121-129.
15. Lindstedt, R., G. Larson, P. Falk, H. Leffler, and C. Svanborg. 1991. The receptor repertoire defines the host range for attaching Escherichia coli strains that recognize globo-A. Infect. Immun. 59:1086-1092.
16. Roberts, J.A., B.I. Marklund, D. Ilver, M.B. Haslam, G. Kack, R. Baskin, R. Möllby, J. Winberg, and S. Normark. 1994. The Galα(1-4)Gal specific tip adhesin of Escherichia coli P-fimbriae is needed for pyelonephritis to occur in the normal urinary tract. Proc. Natl. Acad. Sci. USA. 91:11889-11893.
17. Winberg, J., R. Möllby, J. Bergström, K.A. Karlsson, I. Leonardsson, M.A. Milh, S. Teneberg, D. Haslam, B.I. Marklund, and S. Normark. 1995. The papG-adhesin at the tip of P-fimbriae provides Escherichia coli with a competitive edge in experimental bladder infections of cynomolgus monkeys. J. Exp. Med. 182:1695-1702.
18. Strömberg, N., B.I. Marklund, B. Lund, D. Ilver, A. Hamers, W. Gaastra, K.A. Karlsson, and S. Normark. 1990. Host-specificity of uropathogenic Escherichia coli depends on differences in binding specificity to Galα(1-4)Gal containing isoreceptors. EMBO (Eur. Mol. Biol. Organ.) J. 9:2001-2010.
19. Tullus, K., K. Hörlin, S.B. Svensson, and G. Källenius. 1984. Epidemic outbreaks of acute pyelonephritis caused by nosocomial spread of P-fimbriated Escherichia coli in children. J. Infect. Dis. 150:728-736.
20. Hopkins, W.J., D.T. Uehling, and E. Balish. 1987. Local and systemic antibody responses accompany spontaneous resolution of experimental cystitis in cynomolgus monkeys. Infect. Immun. 55:1951-1956.
21. Herthelius, M., S.L. Gorbach, R. Möllby, C.E. Nord, L. Pettersson, and J. Winberg. 1989. Elimination of vaginal colonization with Escherichia coli by administration of indigenous flora. Infect, Immun. 57:2447-2451.
22. Herthelius, M., K.-G. Hedström, R. Möllby, C.E. Nord, L. Pettersson, and J. Winberg. 1988. Pathogenesis of urinary tract infections: Amoxicillin induces genital Escherichia coli colonization. Infection. 16:263-266.
23. Kühn, I. 1985. Biochemical fingerprinting of Escherichia coli: a simple method for epidemiological investigation. J. Microbiol. Methods. 3:159-170.
24. Svensson, S.B., G. Källenius, R. Möllby, H. Hultberg, and J. Winberg. 1982. Rapid identification of P-fimbriated Escherichia coli by a receptor-specific particle agglutination test. Infection. 10:209-214.
25. Lindberg, A.A., and T. Holme. 1972. Evaluation of some extraction methods for the preparation of bacterial lipopolysaccharides for structural analysis. Acta Pathol. Microbiol. Scand. Sect. B. Microbiol. Immunol. 80:751-759.
26. Evans, D.G., Jr., and W. Tjoa. 1977. Hemagglutination of human group A erythrocytes by enterotoxigenic Escherichia coli isolated from adults with diarrhea: correlation with colonization factor. Infect. Immun. 18:330-337.
27. Källenius, G., and J. Winberg. 1978. Bacterial adherence to periurethral epithelial cells in girls prone to urinary tract infections. Lancet. ii:540-543.
28. Herthelius-Elman, M., R. Möllby, C.E. Nord, and J. Winberg. 1992. The effect of amoxicillin on vaginal colonization resistance and normal vaginal flora in monkeys. J. Antimicrob. Chemother. 29:329-340.
29. Karlsson, K.-A. 1987. Preparation of total non-acid glycolipids for overlay analysis of receptors for bacteria and viruses, and for other studies. Meth. Enzymol. 138:212-220.
30. Folch-Pi, J., M. Lees, and G.H. Sloane-Stanley. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226:497-509.
31. Hansson, C.G., K.-A. Karlsson, G. Larson, N. Strömberg, and J. Thurin. 1985. Carbohydrate-specific adhesion of bacteria to thin-layer chromatograms: a rationalized approach to the study of host cell glycolipid receptors. Anal. Biochem. 146:158-163.
32. Aggarwal, B.B., T.E. Eessalu, and P.E. Hass. 1985. Characterization of receptors for human tumour necrosis factor and their regulation with γ-interferon. Nature (Lond.). 318:665-667.
33. Herthelius, M., R. Möllby, C.E. Nord, and J. Winberg. 1989. Amoxicillin promotes vaginal colonization with adhering E. coli present in faeces. Paediatr. Nephrol. 3:443-447.
34. Bock, K., M.E. Breimer, A. Brignole, G.C. Hansson, K.A. Karlsson , G. Larson, H. Leffler, B.E. Samuelsson, N. Strömberg, and C. Svanborg-Edén. 1985. Specificity of binding of a strain of uropathogenic Escherichia coli to Galα(1-4)Gal-containing glycosphingolipids. J. Biol. Chem. 260:8545-8551.
35. Jensen, J., E. Balish, K. Mizutani, and D.T. Uehling. 1982. Resolution of induced urinary tract infection: an animal model to assess bladder immunization. J. Urol. 127:1220-1223.
36. Uehling, D.T., K. Mizutani, and E. Balish. 1978. Effect of immunization on bacterial adherence to urothelium. Investig. Urol. 16:145-147.
37. Jensen, J., D.T. Uehling, K. Kim, K. Seagren-Rasmussen, and E. Balish. 1984. Enhanced immune response in the urinary tract of the rat following vaginal immunization. J. Urol. 132:164-166.
38. Fairley, K.F., N.E. Carson, R.C. Gutch, P. Leighton, A.D. Grounds, E.C. Laird, P.H. McCallum, R.L. Sleeman, and C.M. O'Keefe. 1971. Site of infection in acute urinary-tract infection in general practice. Lancet. ii:615-618.
39. Holmgren, J., C. Czerkinsky, N. Lycke, and A.-M. Svennerholm. 1994. Strategies for the induction of immune responses at mucosal surfaces making use of cholera toxin B subunit as immunogen, carrier, and adjuvant. Am. J. Trop. Med. Hyg. 50(Suppl. 5):42-54.
40. Kunin, C.M. 1997. Detection, Prevention and Management of Urinary Tract Infections. 5th edition. Williams & Wilkins, Baltimore. 293-294.
41. de Man, P., U. Jodal, K. Lincoln, and C. Svanborg. 1988. Bacterial attachment and inflammation in the urinary tract. J. Infect. Dis. 158:29-35.
42. Zhang, J.P., and S. Normark. 1996. Induction of gene expression in Escherichia coli after pilus mediated adherence. Science (Wash. DC). 273:1234-1236.