1S,3R-ACPD induces a region of negative slope conductance in the steady- state current-voltage relationship of hippocampal pyramidal cells

Journal of Neurophysiology

Volumn 77, Issue 1, 1997, Pages 221-228

  Lüthi, Anita ^a   Gähwiler, Beat H ^a   Gerber, Urs ^a  

^a University of Zurich Brain Research Institute   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; BARIUM ION; CALCIUM ION; METABOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID; POTASSIUM ION;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM TRANSPORT; CELL MEMBRANE TRANSPORT; CONTROLLED STUDY; HIPPOCAMPUS; NERVE CELL MEMBRANE CONDUCTANCE; NONHUMAN; POTASSIUM CONDUCTANCE; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; TRANSPORT KINETICS;

EID: 1842407222     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.1997.77.1.221     Document Type: Article

References (41)

1. ANWYL R. Modulation of vertebrate neuronal calcium channels by transmitters Brain Res. Rev. 16: 265-281, 1991.
2. BEAN, B. P. Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence. Nature Lond. 340: 153-156.
3. BOLAND, L. M. AND BEAN, B. P. Modulation of N-type calcium channels in bullfrog sympathetic neurons by luteinizing hormone-releasmg hormone: kinetics and voltage dependence. J. Neurosci. 13: 510-533, 1993.
4. BROWN D. A. M currents In: Ion Channels, edited by T. Narahash. New York: Plenum, 1988, vol. 1, p. 55-94.
5. + current in a vertebrate neurone. Nature Lond, 283: 673-676, 1980.
6. BROWN, D. A., GÄHWILER, B. H., GRIFFITH, W. H., AND HALLIWELL, J. V. Membrane currents in hippocampal neurons. Prog. Brain Res. 83: 141-160, 1990.
7. BROWN, D. A. AND GRIFFITH, W. H. Calcium-activated outward current in voltage-clamped hippocampal neurones of the guinea-pig. J. Physiol. Lond. 337: 287-301, 1983.
8. CAESER, M., BROWN, D. A., GÄHWILER, B. H., AND KNÖPPEL T. Characterization of a calcium-dependent current generating a slow afterdepolarization of CA3 pyramidal cells in rat hippocampal slice cultures. Eur. J. Neurosci. 5: 560-569, 1993.
9. CHARPAK, S. AND GÄHWILER, B. H. Glutamate mediates a slow synaptic response in hippocampal slice cultures. Proc. R. Soc. Lond. B Biol. Sci. 243: 221-226, 1991.
10. CHARPAK, S., GÄHWILER, B. H., DO, K. Q., AND KNÖPFEL, T. Potassium conductances in hippocampal neurons blocked by excitatory amino-acid transmitters. Nature Lond. 347: 765-767, 1990.
11. 2+)-activated nonspecific cationic current in CA1 hippocampal neurons. J. Neurophysiol. 72: 1561-1569, 1994.
12. DIVERSÉ-PIERLUISSI, M., GOLDSMITH, P. K., AND DUNLAP, K. Transmitter-mediated inhibition of N-type calcium channels in sensory neurons involves multiple GTP-binding proteins and subunits. Neuron 14: 191-200, 1995.
13. 2+ current in excitable cells. Trends Neurosci. 19: 35-43, 1996.
14. GÄHWILER, B. H. Organotypic monolayer cultures of nervous tissue. J. Neurosci. Methods 4: 329-342, 1981.
15. GÄHWILER, B. H. AND BROWN, D. A. Functional innervation of cultured hippocampal neurones by cholinergic afferents from co-cultured septal explants. Nature Lond. 313: 577-579, 1985.
16. GERBER, U. AND GÄHWILER, B. H. Modulation of ionic currents by metabotropic glutamate receptors in the CNS. In: The Metabotropic Glutamate Receptors, edited by P. J. Conn and J. Patel. Totowa, NJ: Humana, 1994, p. 125-146.
17. GERBER, U., LÜTHI, A., AND GÄHWILER, B. H. Inhibition of a slow synaptic response by a metabotropic glutamate receptor antagonist in hippocampal CA3 pyramidal cells. Proc. R. Soc. Lond. B Biol. Sci. 254: 169-172, 1993.
18. GUÉRINEAU, N. C., BOSSU, J.-L., GÄHWILER, B. H., AND GERBER, U. Activation of a nonselective cationic conductance by metabotropic glutamatergic and muscarinic agonists in CA3 pyramidal neurons of the rat hippocampus. J. Neurosci. 15: 4395-4407, 1995.
19. + current by metabotropic glutamate and muscarinic receptors in rat CA3 cells: mediation by G-proteins. J. Physiol. Lond. 474: 27-33, 1994.
20. HALLIWELL, J. V. AND ADAMS, P. R. Voltage-clamp analysis of muscarinic excitation in hippocampal neurons. Brain Res. 250: 71-92, 1982.
21. HODGKIN, A. L. AND HUXLEY, A. F. The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J. Physiol. Lond. 116: 497-506, 1952.
22. LUEBKE, J. I. AND DUNLAP, K. Sensory neuron N-type calcium currents are inhibited by both voltage-dependent and -independent mechanisms. Pfluegers Arch. 428: 499-507, 1994.
23. LÜTHI, A., GÄHWILER, B. H., AND GERBER, U. Potentiation of a metabotropic glutamatergic response following NMDA receptor activation in rat hippocampus. Pfluegers Arch. 427: 197-202, 1994.
24. LÜTHI, A., GÄHWILER, B. H., AND GERBER, U. Voltage- and time-dependency of 1S,3R-ACPD action on I/V characteristics of CA3 pyramidal cells in rat hippocampal slice cultures. Soc. Neurosci. Abstr. 21: 613, 1995.
25. LÜTHI, A., GÄHWILER, B. H., AND GERBER, U. A slowly inactivating potassium current in CA3 pyramidal cells of rat hippocampus in vitro. J. Neurosci. 16: 586-594, 1996.
26. MADISON, D. V., LANCASTER, B., AND NICOLL, R. A. Voltage clamp analysis of cholinergic action in the hippocampus. J. Neurosci. 7: 733-741, 1987.
27. 2+ of NMDA responses in spinal cord neurones. Nature Lond. 309: 261-263, 1984.
28. MCCORMICK, D. A. AND VON KROSIGK, M. Corticothalamic activation modulates thalamic firing through glutamate "metabotropic" receptors. Proc. Natl. Acad. Sci. USA 89: 2774-2778, 1992.
29. MCDONALD, J. W., FIX, A. S., TIZZANO, J. P., AND SCHOEPP, D. D. Seizures and brain injury in neonatal rats induced by 1S,3R-ACPD, a metabotropic glutamate receptor agonist. J. Neurosci. 13: 4445-4455, 1993.
30. MERLIN, L. R., TAYLOR, G. W., AND WONG, R. K. S. Role of metabotropic glutamate receptor subtypes in the patterning of epileptiform activities in vitro. J. Neurophysiol. 74: 896-900, 1995.
31. NAKANISHI, S. Metabotropic glutamate receptors: synaptic transmission, modulation, and plasticity. Neuron 13: 1031-1037, 1994.
32. NOWAK, L., BREGESTOVSKI, P., ASCHER, P., HERBET, A., AND PROCHIANTZ, A. Magnesium gates glutamate-activated channels in mouse central neurones. Nature Lond. 307: 462-465, 1984.
33. SCHOEPP, D. D. AND CONN, P. J. Metabotropic glutamate receptors in brain function and pathology. Trends Pharmacol. Sci. 14: 13-20, 1993.
34. SEGAL, M. AND BARKER, J. L. Rat hippocampal neurons in culture: potassium conductances. J. Neurophysiol. 51: 1409-1433, 1984.
35. STORM, J. F. An after-hyperpolarization of medium duration in rat hippocampal pyramidal cells. J. Physiol. Lond. 409: 171-90, 1989.
36. + currents in hippocampal pyramidal neurons. Semin. Neurosci. 5: 79-92, 1993.
37. STORM, J. F. AND HELLIESEN, M. Evidence that a barium-sensitive potassium current contributes to the resting potential and spike repolarization in rat hippocampal neurons. Soc. Neurosci. Abstr. 15: 77, 1989.
38. STREIT, P., THOMPSON, S. M., AND GÄHWILER, B. H. Anatomical and physiological properties of GABAergic neurotransmission in organotypic slice cultures of rat hippocampus. Eur. J. Neurosci. 1: 603-615, 1989.
39. SWARTZ, K. J. AND BEAN, B. P. Inhibition of calcium channels in rat CA3 pyramidal neurons by a metabotropic glutamate receptor. J. Neurosci. 12:4358-4371, 1992.
40. 0. Science Wash. DC 242: 1433-1437, 1988.
41. WANG, Z. AND MCCORMICK, D. A. Control of firing mode of corticotectal and corticopontine layer V burst-generating neurons by norepinephrine, acetylcholine, and 1S,3R-ACPD. J. Neurosci. 13: 2199-2216, 1993.