Benign monoclonal gammopathy with IgG anti-DNA, anti-Sm and anti-F(ab')2 activity

Clinical and Experimental Rheumatology

Volumn 15, Issue 1, 1997, Pages 33-38

  Williams Jr , R C ^a,d   Malone, C C ^a   Silvestris, F ^b   Nickerson, K G ^c  

^a UNIVERSITY OF FLORIDA HEALTH   (United States)

^b UNIVERSITY OF BARI   (Italy)

^c New York Presbyterian Hospital Columbia University Medical Center   (United States)

^d UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

anti DNA; anti F(ab')2; M component

Indexed keywords

DNA ANTIBODY; IMMUNOGLOBULIN F(AB')2 FRAGMENT; IMMUNOGLOBULIN M;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; MONOCLONAL IMMUNOGLOBULINEMIA; PRIORITY JOURNAL;

AGED; ANIMALS; ANTIBODIES, ANTINUCLEAR; AUTOANTIBODIES; AUTOANTIGENS; DNA; FEMALE; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN IDIOTYPES; LUPUS ERYTHEMATOSUS, SYSTEMIC; PARAPROTEINEMIAS; RABBITS; REFERENCE VALUES; RIBONUCLEOPROTEINS, SMALL NUCLEAR;

EID: 1842404154     PISSN: 0392856X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (37)

1. KYLE RA: Monoclonal gammopathy of undetermined significance: natural history in 241 cases. Am J Med 1978; 64: 814-26.
2. FINE JM, LAMBIN P, MULLER JY: The evolution of asymptomatic monoclonal gammopathies: A follow up of 20 cases over periods of 3-14 years. Acta Med 1979; 205: 339-41.
3. RADL J, SEPERS JM, SKVARIL F, MORELL A, HIJAMNS W: Immunoglobulin patterns in humans over 95 years of age. Clin Exp Immunol 1975; 22: 84-90.
4. RADL J, HOLLANDER CF, VAN DEN BERG P, DEGLOPPER E: Idiopathic paraproteinemia I studies in an animal model -the aging C57BL/Kalw Rij mouse. Clin Exp Immunol 1978; 33: 395-402.
5. DANON F, SELIGMAN M: Transient human monoclonal immunoglobulins. Scand J Immunol 1972; 1: 323-8.
6. HALLEN J: Discrete gammaglobulin (M-components) in serum: Clinical study of 150 subjects without myelomatosis. Acta Med Scand 1966; 462 (Suppl. 1): 127.
7. SCHOBEL B, WEWALKA FL: Temporäre Kryptogenetische Paraproteinämie Schweiz. Med Wschr 1965; 95: 1301-4.
8. HAAS H, ANDERS S, BORNKAMM GW, MANNWEILER E, SCHMITZ H, RADL J, SCHLAAK M: Do infections induce monoclonal immunoglobulin components? Clin Exp Immunol 1990; 81: 435-40.
9. ZETTERVALL O, NILSSON IM: Acquired von Willebrand's disease caused by a monoclonal antibody. Acta Med Scand 1978; 204: 521-8.
10. SELIGMANN M, SASSY C, CHEVALIER A: A human IgG myeloma protein with anti-α2 macroglobulin antibody activity. J Immunol 1973; 110: 85-90.
11. ROUSSEL B, ARVIEUX J, JACOB MC, LORIMIER P, CAVIGIOLI E, MICOUIN C: A human monoclonal IgM with autoantibody activities against heparan sulphate and the milotic spindle. Clin Exp Immunol 1990; 82: 294-9.
12. KONRAD RJ, KRICKA LJ, GOODMAN DBP, GOLDMAN J, SILBERSTEIN LE: Brief Report: Myeloma-associated paraprotein directed against the HIV-1 p24 antigen in an HIV-1-sero-positive patient. N Engl J Med 1993; 328: 1817-9.
13. 2 and anti-DNA antibodies. Clin Immunol Immunopathol 1996; 80: 194-203.
14. 2 antibody is linked through idiotypic networks to production of anti-DNA and other autoantibodies. Lupus 1995; 4: 102.
15. DAVIDSON A, SMITH A, KATZ J, PREUD HOMME JL, SOLOMON A, DIAMOND B: A cross-reactive idiotype on anti-DNA antibodies defines an H-chain determinant present almost exclusively on IgG antibodies. J Immunol 1989; 143: 174-80.
16. DAVIDSON A, PREUD'HOMME JL, SOLOMON A, CHANG MD, BEEDE S, DIAMOND B: Idiotypic analysis of myeloma proteins: Anti-DNA activity of monoclonal immunoglobulins bearing an SLE idiotype is more common in IgG than IgM antibodies. J Immunol 1987; 138: 1515-8.
17. HALPERN RA, DAVIDSON A, LAZO A, SOLOMON G, LAHITA R, DIAMOND B. Familial systemic lupus: Presence of a cross-reactive idiotype in healthy family members. J Clin Invest 1985; 76: 731-6.
18. WILLIAMS RC JR SCHRIBER AD, MALONE CC, SILVESTRIS F, HANNIGAN N, KLEIN-GITELMAN N, NAMYST M, KYLE RA: Expression of F4, 8.12, 3I and 16/6 anti-DNA idiotype-related antigens on cationic human IgG myeloma proteins. Clin Immunol Immunopathol 1994; 73: 215-23.
19. EBLING F, HAHN BH: Restricted subpopulations of DNA antibodies in kidneys of mice with systemic lupus: Comparison of antibodies in serum and renal eluates. Arthritis Rheum 1980; 23: 392-3.
20. SUZUKI N, HARADA T, MIZUSHIMA Y, SAKANE T: Possible pathogenic role of cationic anti-DNA autoantibodies in the development of nephritis in patients with systemic lupus erythematosus. J Immunol 1993; 151: 1128-36.
21. 2 antibodies and possible immunologic control mechanisms in systemic lupus. Arthritis Rheum 1984; 27: 1387-96.
22. 2 antibodies. Clin Immunol Immunopathol 1987; 42: 50-62.
23. KAVAI M, BANYAI A, ZSINDELY A, SONKOLY I, SZEGEDI G: Enzyme-linked immunosorbent assay for antibodies to native DNA in sera of patients with SLE. J Immunol Methods 1982; 48: 169-75.
24. EATON RB, SCHNEIDER G, SCHUR PH: Enzyme immunoassay for antibodies to native DNA specificity and quality of antibodies. Arthritis Rheum 1983; 36: 52-62.
25. 2 antibody cross reacts with DNA and other nuclear antigens. Arthritis Rheum 1996 (in press).
26. MATTHYSSENS G, RABBITS TH: Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region. Proc Natl Acad. Sci USA 1980; 77: 6561-5.
27. DEMAISON C, CHASTAGNER P, THÈZE J, ZOUALI M: Somatic diversification in the heavy chain variable region genes expressed by human autoantibodies bearing a lupus-associated nephritogenic anti-DNA idiotype. Proc Nat Acad Sci USA 1994; 91: 514-8.
28. DIAMOND B, KATZ JB, PAUL E, ARANOW C, LUSTGARTEN D, SCHARFF MD: The role of somatic mutation in the pathogenic anti-DNA response. Annu Rev Immunol 1992; 10: 731-57.
29. ZOUALI M: Development of human antibody variable genes in systemic autoimmunity. Immunological Rev 1992; 128: 73-99.
30. ZOUALI M, FINE JM, EYQUEM A: Anti-DNA autoantibody activity and idiotypic relationships of human monoclonal proteins. Eur J Immunol 1984; 14: 1085-9.
31. WATTS RA, WILLIAMS W, LEPAGE S, NORDEN A, SOLTYS A, SWANA G, ADDISON I, HAY FC, ISENBERG DA: Analysis of autoantibody reactivity and common idiotype PR4 expression of myeloma proteins. J Autoimmunity 1989; 2: 689-700.
32. MACGREGOR AJ, KALSI J, RAVIRAJAN CT, LEAKER B, WATTS R, WINSKA-WILOCH H, KNIGHT B, NORDEN A, ISENBERG DA, CAMBRIDGE G: Analysis of antibody reactivity in the sera of 42 patients with paraproteinemia. Autoimmunity 1992; 13: 101-5.
33. ZOUALI M, FINE JM, EYQUEM A: A human monoclonal IgG-1 with anti-idiotypic activity against anti-human thyroglobulin autoantibody. J Immunol 1984; 133: 190-4.
34. REICHLIN M, MARTIN A, TAYLOR-ALBERT E, TZUZAKA K, ZHANG W, WOLFSON REICHLIN M, KOEN E, EBLING FM, TSAO B, HAHN BH: Lupus autoantibodies to native DNA cross-react with the A and D SnRNP polypeptides. J Clin Invest 1994; 93: 443-9.
35. SELIGMANN M, BROUET JC: Antibody activity of human myeloma globulins. Semin Hematol 1973; 10: 163-77.
36. ZOUALI M, STOLLAR BD: Thymine and guanine base specificity of human myeloma proteins with anti-DNA activity. J Clin Invest 1986; 78: 1173-8.
37. SHOENFELD Y, BEN-YEHUDA O, NEPARTSTEK Y, WILNER Y, FROLICHMAN R, SCHATTNER A, LAVIE G, JOSHUA H, PINKHAS J, KENNEDY RC, SCHWARTZ RS, PICK AI: The detection of a common idiotype of anti-DNA antibodies in the sera of patients with monoclonal gammopathies. J Clin Immunol 1986; 6: 194-204.