A naturally occurring mutation in IRS-1 responsible for severe insulin resistance in a human patient?

Experimental and Clinical Endocrinology and Diabetes

Volumn 104, Issue , 1996, Pages 64-65

  Humphries, P ^a   Krook, A ^a   O'Rahilly, S ^a   Whitehead, J ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 1842393124     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0029-1211543     Document Type: Article

References (4)

1. Rocchi S, Tartare-Deckert S, Mothe S, van Obberghen E: Identification by mutation of the tyrosine residues in the insulin receptor substrate-1 affecting association with the tyrosine phosphatase 2C and phosphatidylinositol 3-ki-nase. Endrocrinology 136: 5291-5297, 1995
2. Rordorf-Nikolic T, Horn DJV, Chen D, White MF, Backer JM: Regulation of phosphatidylinositol 3-kinase by tyrosine phosphoproteins. Journal of Biological Chemistry 270: 3662-3666, 1995
3. Songyang Z, Carraway KL, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, Lorenzo MJ, Ponder BJ, Mayer BJ, Cantley LC: Catalytic specificity of protein-tyrosine kinase is critical for selective signalling. Nature 373: 536-539, 1995
4. White M: The IRS-1 signalling system. Current Opinion in Genetics and Development 4: 47-54, 1994