Discrepancies between meta-analyses and subsequent large randomized, controlled trials

New England Journal of Medicine

Volumn 337, Issue 8, 1997, Pages 536-542

  LeLorier, Jacques ^a   Grégoire, Geneviève ^b   Benhaddad, Abdeltif ^b   Lapierre, Julie ^b   Derderian, François ^b  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; GLYCERYL TRINITRATE; HYPOCHOLESTEROLEMIC AGENT; LOW MOLECULAR WEIGHT HEPARIN; MAGNESIUM; STREPTOKINASE;

ABDOMINAL SURGERY; ACUTE HEART INFARCTION; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HUMAN; HYPERCHOLESTEROLEMIA; INTRAUTERINE GROWTH RETARDATION; META ANALYSIS; PREECLAMPSIA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING CESSATION;

HUMANS; META-ANALYSIS; ODDS RATIO; PREDICTIVE VALUE OF TESTS; RANDOMIZED CONTROLLED TRIALS; SENSITIVITY AND SPECIFICITY;

EID: 1842376945     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199708213370806     Document Type: Article

References (42)

1. Feinstein AR. Meta-analysis: statistical alchemy for the 21st century. J Clin Epidemiol 1995;48:71-9.
2. Horwitz RI. "Large-scale randomized evidence: large, simple trials and overviews of trials": discussion: a clinician's perspective on meta-analyses. J Clin Epidemiol 1995;48:41-4.
3. Bailar JC III. The practice of meta-analysis. J Clin Epidemiol 1995;48: 149-57.
4. Meinert CL. Meta-analysis: science or religion? Control Clin Trials 1989;10:Suppl:257S-263S.
5. Abrahamson JH. Meta-analysis: a review of pros and cons. Public Health Rev 1990/91;18:1-47.
6. Villar J, Carroli G, Belizán JM. Predictive ability of meta-analyses of randomised controlled trials. Lancet 1995;345:772-6.
7. Mantel N, Haenszel W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959;22:719-48.
8. McNemar Q. Psychological statistics. 3rd ed. New York: John Wiley, 1962.
9. EMERAS (Estudio Multicéntrico Estreptoquinasa Repúblicas de América del Sur) Collaborative Group. Randomised trial of late thrombolysis in patients with suspected acute myocardial infarction. Lancet 1993; 342:767-72.
10. Yusuf S, Collins R, Peto R, et al. Intravenous and intracoronary fibrinolytic therapy in acute myocardial infarction: overview of results on mortality, reinfarction and side-effects from 33 randomized controlled trials. Eur Heart J 1985;6:556-85.
11. Yusuf S, Sleight P, Held P, McMahon S. Routine medical management of acute myocardial infarction: lessons from overviews of recent randomized controlled trials. Circulation 1990;82:Suppl II:II-117-II-134.
12. Woods KL, Fletcher S, Roffe C, Haider Y. Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 1992;339:1553-8.
13. Teo KK, Yusuf S, Collins R, Held PH, Peto R. Effects of intravenous magnesium in suspected acute myocardial infarction: overview of randomised trials. BMJ 1991;303:1499-503.
14. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-9.
15. Law MR, Wald NJ, Thompson SG. By how much and how quickly does reduction in serum cholesterol concentration lower risk of ischaemic heart disease? BMJ 1994;308:367-72.
16. Rossouw JE, Lewis B, Rifkind BM. The value of lowering cholesterol after myocardial infarction. N Engl J Med 1990;323:1112-9.
17. Ravnskov U. Cholesterol lowering trials in coronary heart disease: frequency of citation and outcome. BMJ 1992;305:15-9. [Erratum, BMJ 1992;305:505.]
18. Ghana VAST Study Team. Vitamin A supplementation in northern Ghana: effects on clinic attendances, hospital admissions, and child mortality. Lancet 1993;342:7-12. [Erratum, Lancet 1993;342:250.]
19. Glasziou PP, Mackerras DE. Vitamin A supplementation in infectious diseases: a meta-analysis. BMJ 1993;306:366-70.
20. Fawzi WW, Chalmers TC, Herrera MG, Mosteller F. Vitamin A supplementation and child mortality: a meta-analysis. JAMA 1993;269:898-903.
21. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators. Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. Lancet 1993;342: 821-8.
22. Furberg CD, Yusuf S. Effect of drug therapy on survival in chronic congestive heart failure. Am J Cardiol 1988;62:41A-45A.
23. Kakkar VV, Cohen AT, Edmonson RA, et al. Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery: the Thromboprophylaxis Collaborative Group. Lancet 1993;341:259-65.
24. Nurmohamed MT, Rosendaal FR, Buller HR, et al. Low-molecular-weight heparin versus standard heparin in general and orthopaedic surgery: a meta-analysis. Lancet 1992;340:152-6.
25. Leizorovicz A, Haugh MC, Chapuis FR, Samama MM, Boissel JP. Low molecular weight heparin in prevention of perioperative thrombosis. BMJ 1992;305:913-20.
26. Lassen MR, Borris LC, Christiansen HM, et al. Clinical trials with low molecular weight heparins in the prevention of postoperative thromboembolic complications: a meta-analysis. Semin Thromb Hemost 1991;17: Suppl 3:284-90.
27. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. CLASP: a randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. Lancet 1994;343:619-29.
28. Imperiale TF, Petrulis AS. A meta-analysis of low-dose aspirin for the prevention of pregnancy-induced hypertensive disease. JAMA 1991;266: 260-4.
29. The SOLVD Investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fractions and congestive heart failure. N Engl J Med 1991;325:293-302.
30. Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico. GISSI-3: effects of lisinopril and transdermal glyceryl trinitrate singly and together on 6-week mortality and ventricular function after acute myocardial infarction. Lancet 1994;343:1115-22.
31. Yusuf S, Collins R, MacMahon S, Peto R. Effect of intravenous nitrates on mortality in acute myocardial infarction: an overview of the randomised trials. Lancet 1988;1:1088-92.
32. Wood WC, Budman DR, Korzun AH, et al. Dose and dose intensity of adjuvant chemotherapy for stage II, node-positive breast carcinoma. N Engl J Med 1994;330:1253-9. [Erratum, N Engl J Med 1994;331:139.]
33. Hryniuk W, Levine MN. Analysis of dose intensity for adjuvant chemotherapy trials in stage II breast cancer. J Clin Oncol 1986;4:1162-70.
34. The Trials of Hypertension Prevention Collaborative Research Group. The effects of nonpharmacologic interventions on blood pressure of persons with high normal levels: results of the Trials of Hypertension Prevention, phase I. JAMA 1992;267:1213-20. [Erratum, JAMA 1992;267: 2330.]
35. Cutler JA, Follmann D, Elliott P, Suh I. An overview of randomized trials of sodium reduction and blood pressure. Hypertension 1991;17: Suppl:I27-I33.
36. Whelton PK, Thaker GK, Klag MJ, Seidler AJ. Blood pressure effects of potassium supplementation. Circulation 1989;80:Suppl II:II-301. abstract.
37. Cutler JA, Brittain E. Calcium and blood pressure: an epidemiologic perspective. Am J Hypertens 1990;3:137S-146S.
38. Hollis JF, Lichtenstein E, Vogt TM, Stevens JV, Biglan A. Nurse-assisted counseling for smokers in primary care. Ann Intern Med 1993; 118:521-5.
39. Kottke TE, Battista RN, DeFriese GH, Brekke ML. Attributes of successful smoking cessation interventions in medical practice: a meta-analysis of 39 controlled trials. JAMA 1988;259:2883-9.
40. Grégoire G, Derderian F, Le Lorier J. Selecting the language of the publications included in a meta-analysis: is there a Tower of Babel bias? J Clin Epidemiol 1995;48:159-63.
41. Cook DJ, Guyatt GH, Laupacis A, Sackett DL, Goldberg RJ. Clinical recommendations using levels of evidence for antithrombotic agents. Chest 1995;108:Suppl:227S-230S.
42. Horwitz RI. Complexity and contradiction in clinical trial research. Am J Med 1987;82:498-510.