A comparison of p53 and p16 expression in human tumor cells treated with hyperthermia or ionizing radiation

International Journal of Cancer

Volumn 72, Issue 2, 1997, Pages 307-312

  Valenzuela, María Teresa ^a   Núñez, María Isabel ^a   Villalobos, Mercedes ^a   Siles, Eva ^a   McMillan, Trevor J ^b   Pedraza, Vicente ^a   Ruiz De Almodóvar, J Mariano ^a,c  

^a UNIVERSITY OF GRANADA   (Spain)

^b LANCASTER UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P16; PROTEIN P53;

ARTICLE; CELL CYCLE G1 PHASE; CONTROLLED STUDY; GAMMA IRRADIATION; GENE EXPRESSION; HEAT SHOCK; HEAT TREATMENT; HUMAN; HUMAN CELL; HYPERTHERMIC THERAPY; IONIZING RADIATION; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; RADIOSENSITIVITY; TUMOR CELL LINE; TUMOR SUPPRESSOR GENE;

CARRIER PROTEINS; CYCLIN-DEPENDENT KINASE INHIBITOR P16; GAMMA RAYS; GENES, TUMOR SUPPRESSOR; HUMANS; HYPERTHERMIA, INDUCED; NEOPLASMS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 1842374384     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0215(19970717)72:2<307::AID-IJC18>3.0.CO;2-C     Document Type: Article

References (22)

1. ARAP, W., NISHIKAWA, R., FURNARI, F.B., CAVENEE, W.K. and SU HUANG, H.J., Replacement of the P16/CDKN2 gene suppresses human glioma cell growth. Cancer Res., 55, 1351-1354 (1995).
2. 1-phase checkpoint by low-oxygen conditions is independent ot p53 status. Mol. cell. Biol., 14, 6264-6277 (1994).
3. GRAÑA, X., and REDDY, E.P., Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclins dependent kinase inhibitors (CDKIs). Oncogene, 11, 211-219 (1995).
4. HAINAUT, P., BUTCHER, S. and MILNER, J., Temperature sensitivity for conformation is an intrinsic property of wild-type p53. Brit. J. Cancer, 71, 227-231 (1995).
5. HARTWELL, L.H. and KASTAN, M.B., Cell cycle control and cancer. Science, 266, 1821-1828 (1994).
6. KASTAN, M.B., ONYEKWERE, O., SIDRANSKY, D., VOGELSTEIN, B. and CRAIG, R.W., Participation of p53 protein in the cellular response to DNA damage. Cancer Res., 51, 6304-6311 (1991).
7. KASTAN, M.B., ZHAN, Q., EL-DEIRY, W.S., CARRIER, F., JACKS, T., WALSH, W.V., PLUNKETT, B.S., VOGELSTEIN, B. and FORNACE, A.J. JR., A mammalian cell cycle checkpoint pathway utilizing p53 and Gadd45 is detective in ataxia-telangiectasia. Cell. 71, 587-597 (1992).
8. KHANDJIAN, E.W., Heat treatment induces dephosphorylation of pRb and dissociation of T-antigen/pRb complex during transforming infection with SV40. Oncogene, 10, 359-367 (1995).
9. KUERBITZ, S.J., PLUNKETT, B.S., WALSH, W.V. and KASTAN, M.B., Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. nat. Acad. Sci. (Wash.). 89, 7491-7495 (1992).
10. LI, Y., NICHOLS, M.A., SHAY, J.W. and XIONG, Y., Transcriptional repression of the D-type cvclin dependent kinase inhibitor p16 by the retinoblastoma susceptibility gene product pRb. Concer Res., 54, 6078-6082 (1994).
11. LU, X. and LANE, D.P., Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes. Cell. 75, 765-778 (1993).
12. MERRITT, A.J., POTTEN, C.S., KEMP, J., HICKMAN, J.A., BALMAIN, A., LANE, D.P. and HALL, P.A., The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res., 54, 614-617 (1994).
13. 2/M delay and cellular radiosensitivity. Int. J. Rad. Biol., 66, 373-379 (1994).
14. ROTI ROTI, J.L., MACKEY, M.A. and HIGASHIKUBO, R., The effects of heat shock on cell proliferation. Cell Prolif., 25, 89-99 (1992).
15. ROTI ROTI, J.L. and TURKEL, N., Heat-induced changes in nuclear-associated proteins in normal and thermotolerant HeLa cells. Rad. Res., 139, 73-81 (1994).
16. SERRANO, M., HANNON, G.J. and BEACH, D., A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK 4. Nature (Lond.), 366, 704-707 (1993).
17. SILES, E., VILLALOBOS, M., VALENZUELA, M.T., NÚÑEZ, M.I., GORDON, A., MCMRLAN, T.J., PEDRAZA, V. and RUIZ DEALMODÓVAR, J.M., Relationship between p53 status and radiosensitivity in human tumour cell lines. Brit. J. Cancer. 73, 581-588 (1996).
18. 2/M by p53. Oncogene, 10, 109-115 (1995).
19. INK4. Cancer Res., 54, 5816-5820 (1994).
20. VALENZUELA, M.T., NÚÑEZ, M.I., VILLALOBOS, M., SILES, E., OLEA, N., MCMILLAN, T.J., PEDRAZA, V. and RUIZ DE ALMODÓVAR, J.M., Relationship between doxorubicin cell sensitivity, drug induced DNA double strand breaks, glutathione content and P-glycoprotein in mammalian tumour cells. Anti-Cancer Drugs, 6, 749-757 (1995).
21. XIONG, Y., HANNON, G.J., ZHANG, H., CASSO, D., KOBAYASHI, R. and BEACH, D., p21 is a universal inhibitor of cyclin kinases. Nature (Lond.). 366, 701-704 (1993a).
22. XIONG, Y., ZHANG, H. and BEACH, D., Subunit rearrangement of the cyclin dependent kinases is associated with cellular transformation. Genes Develop., 7, 1572-1583 (1993b).