The prophylactic effects of superoxide dismutase, catalase, desferrioxamine, verapamil and disulfiram in experimental colitis

Journal of the Royal College of Surgeons of Edinburgh

Volumn 42, Issue 1, 1997, Pages 27-30

  Koksoy F N ^a,b   Kose H ^a   Soybir G R ^a   Yalcin O ^a   Cokneseli B ^a  

^a Taksim State Hospital   (Turkey)

^b NONE   (Turkey)

Author keywords

Catalase; Desferrioxamine; Disulfiram; Experimental colitis; Free oxygen radicals; Superoxide dismutase; Verapamil

Indexed keywords

ACETIC ACID; CATALASE; DEFEROXAMINE; DEFEROXAMINE MESYLATE; DISULFIRAM; OXYGEN RADICAL; SUPEROXIDE DISMUTASE; VERAPAMIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; RECTAL DRUG ADMINISTRATION; ULCERATIVE COLITIS;

ACETIC ACID; ANIMALS; CALCIUM CHANNEL BLOCKERS; CATALASE; COLITIS; COLONIC DISEASES; DEFEROXAMINE; DISEASE MODELS, ANIMAL; DISULFIRAM; FREE RADICAL SCAVENGERS; GASTROINTESTINAL AGENTS; MALE; RATS; RATS, INBRED STRAINS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIDEROPHORES; SUPEROXIDE DISMUTASE; ULCER; VERAPAMIL;

EID: 1842372717     PISSN: 00358835     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Fedorak RN, Empey LR, MacArthur C, Jewell LD. Misoprostal provides a colonic mucosal protective effect during acetic acid-induced colitis in rats. Gastroenterology 1990; 98: 615-25.
2. Fitzpatrick LR, Botswich JS, Renzetti M et al. Antiinflammatory effects of various drugs on acetic acid induced colitis in the rat. Agents Actions 1990; 30: 393-102.
3. Sekizuka E, Grisham MB, Li MA et al. Inflammation-induced intestinal hyperemia in the rat: role of neutrophils. Gastroenterology 1988; 95: 1528-34.
4. Bulkley GB. The role of oxygen tree radicals in human disease processes. Surgery 1983; 94: 407.
5. Parks DA, Bulkley GB, Granger DN. Role of oxygen-derived free radicals in digestive tract disease. Surgery 1983; 94: 415-22.
6. Sharon P, Stenson WF. Metabolism of arachidonic acid in acetic acid colitis in rats. Similarity to human inflammatory bowel disease. Gastroenterology 1985; 88: 55-63.
7. Sharon P, Stenson WF. Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 1984; 86: 453-60.
8. Emerit J, Droy-Lefaix MT, Likforman J, Diemert MC. Oxygen free radicals and inflammatory diseases of intestines. J Chir (Paris) 1989; 126: 287.
9. Leung FW, Koo A. Mucosal vascular stasis precedes loss of viability of endothelial cells in rat acetic acid colitis. Dig Dis Sci 1991; 36: 727-32.
10. Welbourn CR, Goldman G, Paterson IS, Valeri CR, Shepro D, Hechtman HB. Pathophysiology of ischemia reperfusion injury: central role of the neutrophil. Br J Surg 1991; 78: 651-5.
11. Högström H, Haglund U. Neutropenia prevents decrease in strength of rat intestinal anastomosis: Partial effect of oxygen free radical scavengers and allopurinol. Surgery 1986; 99: 716-20.
12. Beyer WF Jr, Fridovich I. Superoxide dismutase mimic prepared from desferrioxamine and manganese dioxide. Methods Enzymol USA 1990; 186: 242-9.