Gastric anti-ulcer and cytoprotective effect of l-serine in rats

Research Communications in Molecular Pathology and Pharmacology

Volumn 97, Issue 2, 1997, Pages 171-184

  Tariq, Mohammad ^a   Al Moutaery, Ahmed R ^b  

^a Prince Sultan Military Medical City   (Saudi Arabia)

^b IMAM ABDULRAHMAN BIN FAISAL UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

SERINE; SERINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; DRUG EFFECT; FEMALE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SCORING SYSTEM; STOMACH ACID SECRETION; STOMACH MUCOSA; STOMACH ULCER;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTI-ULCER AGENTS; CAUSTICS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHANOL; FEMALE; GASTRIC ACID; GASTRIC MUCOSA; HEAT; HYDROCHLORIC ACID; INDOMETHACIN; MALE; MUCUS; PEPTIC ULCER; PYLORUS; RATS; RATS, WISTAR; SERINE; SODIUM HYDROXIDE; SOLVENTS; STEREOISOMERISM; SULFHYDRYL COMPOUNDS;

EID: 1842301691     PISSN: 10780297     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Al Moutaery, A. and Tariq, M. (1996). Effect of vitamin E and selenium on hypothermic restraint stress and chemically-induced ulcers. Dig. Dis. Sci. 41 (6): 1165-1171.
2. 2 inhibitor on stress and chemically induced gastroduodenal ulcers. Digestion 58: 129-137.
3. Allen, A. (1978). Structure of gastrointestinal mucus glycoproteins and the viscous and gel-forming properties of mucus. Br. Med. Bull. 34: 28-33.
4. Allen, A., Sellers, L.A. and Bennett, M.K. (1987). The gastric mucosal epithelial barrier: Role of mucus and fibrin. Scand. J. Gastroenterol. 22: 6-13.
5. Baines, A.D., Shaikh, N. and Ho, P. (1990). Mechanisms of perfused kidney cytoprotection by alanine and glycine. Am. J. Physiol. 259: F80-F87.
6. Bell, A.E., Sellers, L.A., Allen, A, Cunliffe, W.J., Morris, E.R. and Ross-Murphy, S.B. (1985). Properties of gastric and duodenal mucus: Effects of proteolysis, disulfide reduction, bile, acid ethanol and hypertonicity on mucus gel structure. Gastroenterology 88: 269-280.
7. Bhargava, K.P., Gupta, M.B. and Tangri, K.K. (1973). Mechanism of ulcerogenic activity of indomethacin and ocyphenbutazone. Eur. J. Pharmacol. 22: 191-195.
8. 2 inhibitor therapy. Surgery 113: 183-191.
9. Chueng, H.C., Gleason, E.M., Nathan, B.A., Lachmann, P.J. and Woodward, J.K. (1981). Effect of clonidine on gastric acid secretion in the rat. J. Pharmacol. Exp. Ther. 217, 121-126: 1981.
10. Corne, S.J., Morrisey, S.M. and Woods, R.J. (1974). A method for the quantitative estimation of gastric barrier mucus. J. Physiol. (Lond) 242: 116-117.
11. Davenport, H.W. (1964). Gastric mucosal injury by fatty acid and acetyl salicylic acids. Gastroenterology 46: 245-253.
12. Granger, D.N. (1988). Role of xanthine oxidase and granulocytes in ischemia reperfusion injury. Am. J. Physiol. 240: H1269-H1275.
13. Griffin, M., Ray, W. and Schaffner, W. (1988). Nonsteroidal anti-inflammatory drug use and death from peptic ulcer in elderly persons. Ann. Intern. Med. 109: 359-363.
14. Guardia, T., Guzman, J.A., Pestchanker, M.J., Guerreiro, E. and Giordano, O.S. (1994). Mucus synthesis and sulfhydryl groups in cytoprotection mediated by dehydroleucodine, a sesquiterpene lactone. J. Nat. Prod. 57: 507-509.
15. Hawkey, C.J. (1990). Non-steroidal anti-inflammatory drugs and peptic ulcers. B. M. J. 300: 278-284.
16. Hills, B.A., Butler, B.D. and Lichtenberger, L.M. (1983). Gastric mucosal barrier. Hydrophobic lining to the lumen of the stomach. Am. J. Physiol. 244: 561-568.
17. Hiraishi, H., Terano, A., Ota, S., Mutoh, H., Sugimoto, T., Harada, T., Razandi, M. and Ivey, K.J. (1994). Protection of cultured rat gastric cells against oxidant induced damage by exogenous glutathione. Gastroenterology 106: 1199-1207.
18. Kiviluoto, T., Paimela, H., Mustonen, H. and Kivilaakso, E. (1991). Exogenous surface-active phospholipid protects necturus gastric mucosa against luminal acid and barrier-breaking agents. Gastroenterology 100: 38-46.
19. Knodell, M., Robert, G., Pamela, L., Garjian, M., Jonathan, B. and Schreiber M. (1987). Newer agents available for treatment of stress-related upper gastrointestinal tract mucosal damage. Am. J. Med. 83: 36-40.
20. Konturek, S.J., Brzozowski, T., Drozdowicz, D. and Beck, G. (1988). Role of leukotrienes in acute gastric lesions induced by ethanol, taurocholate, platelet-activating factor and stress in rats. Dig. Dis. Sci. 33: 806-813.
21. Kosower, N.S. and Kosower, E.M. (1978). The glutathione status of cells. Int. Rev. Cytol. 58: 109-160.
22. Krenitsky, T.A., Tuttle, J.V., Cattau, E.L. and Wang, P. (1974). A comparison of the distribution and electron acceptor specialities of xanthine oxidase and aldehyde oxidase. Comp. Biochem. Physiol. [B] 49: 687-703.
23. Levine, R.J. (1971). A method for rapid production of stress ulcers in rats. In: Peptic Ulcer. Edited by Pfeiffer, C.J. Munksgaard, Copenhagen, pp 92-97.
24. Lichtenberger, L.M., Graziani, L.A., Dial, E.J., Butler, B.D. and Hills, B.A. (1983). Role of surface active phospholipids in gastric cytoprotection. Science 219: 1327-1328.
25. Madan, B.R. and Tariq, M. (1991). Studies on the antisecretory, antiulcer and cytoprotective properties of some branched-chain amino acids. Biomed. Res. 1: 19-28.
26. Mangino, J.E., Kotadia, B. and Mangino M.J. (1996). Characterization of Hypothermic intestinal ischemia reperfusion injury in dogs. Transplantation 62: 173-178.
27. Mebus, C.A., Welsh, F. and Working, P.K. (1989). Attenuation of 2-methoxyethanol-induced testicular toxicity in the rat by simple physiological compounds. Toxicol. Appl. Pharmacol. 99: 110-121.
28. Moody, F.G. and Durbin, R.P. (1965). Effects of glycine and other instillates on concentration of gastric acid. Am. J. Physiol. 209: 122-126.
29. Needleman, P., Turk, J., Jacshik, B., Morrison, A. and Lefkowith, J. (1986). Arachidonic acid metabolism. Annu. Rev. Biochem. 55: 69.
30. 2 and oxygenated free radicals in mucosal damage after small intestinal ischemia and reperfusion. Am. J. Surg. 57: 562-565.
31. Parks, D.A., Bulkey, D.B. and Granger, D.N. (1983). Role of oxygen derived free radicals in digestive tract diseases. Surgery 94: 415-422.
32. Parks, D.A., Williams, T.K. and Beckman, J.S. (1988). Conversion of xanthine dehydrogenase to oxidase in ischemic rat intestine: A reevaluation. Am J. Physiol. 245: G768-G774.
33. 4 and prostanoid release: Relation to ethanol-induced injury. Br. J. Pharmacol. 93: 937-943.
34. Rainsford, K.D. (1983). Microvascular injury during gastric mucosal damage by anti-inflammatory drugs in pigs and rats. Agents Actions 13: 5-6.
35. Salim, A.S. (1992). Sulfhydryl-containing agents: A new approach to the problem of refractory peptic ulceration. Pharmacology 45: 301-306.
36. Schoenberg, M., Muhl, E. Sellin, D., Younes, M., Schildberg, F. and Hagluno, V. (1984). Posthypotensive generation of superoxide free radicals - possible role in the pathogenesis of the intestinal mucosal damage. Act. Clin. Scand. 150: 301-309.
37. Schiantarelli, P., Cadel, S. and Folco, G.C. (1984). Gastroprotective effects of morniflumate, an esterified anti-inflammatory drug. Arzniem Forsch 34: 885-890.
38. Sedlak, J. and Lindsay, R.H. (1968). Estimation of total protein bound and nonprotein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 25: 192-195.
39. Shay, H., Komrove, S.A., Fels, S.E., Meraze, D., Gruenstein, M. and Siplet, H. (1945). A simple method for uniform production of gastric ulceration in the rat. Gastroenterology 5: 43-61.
40. Slomiany, A., Witas, H., Aono, M. and Slomiany, B.L. (1983). Covalently linked fatty acids in gastric mucus glycoprotein of cystic fibrosis patients. J. Biol. Chem. 258: 8535-8538.
41. Slomiany, B.L., Piasek, A., Sarosiek, J. and Slomiany, A. (1985). The role of surface and intracellular mucus in gastric mucosal protection against hydrogen ion. Compositional differences. Scand. J. Gastroenterol. 20: 1191-1196.
42. Sogabe, K., Roeser, N.F., Venkatchalam, M.A. and Weinberg, J.M. (1996). Differential cytoproteciton by glycine against oxidant damage to proximal tubule cells. Kidney Int. 50: 845-854.
43. Somero, G.N. (1986). Protons, osmolytes, and fitness of internala milieu for protein function. Am. J. Physiol. 251: R197-R213.
44. Spec-Brand, R., Strous, G.J.A.M. and Kramer, M.F. (1980). Isolation and partial characterization of rat gastric mucous glycoprotein. Biochim. Biophys. Acta. 621: 104-116.
45. Swarm, R.A., Ashley, S.W., Soybel, D.I., Ordway, F.S. and Cheung, L.Y. (1987). Protective effect of exogenous phospholipid on aspirin-induced gastric mucosal injury. Am. J. Surg. 153: 48-53.
46. Szabo, S., Trier, J.S. and Frankel, P.W. (1981). Sulfhydryl compounds may mediate gastric cytoprotection. Science 214: 200-202.
47. Szelenyi, I. and Engler, H. (1986). Cytoprotective of gastric surfactant in the ethanol-produced mucosal injury of the rat. Pharmacology 33: 199-205.
48. Takagi, A., Slomiany, B.L., Kosmola, M. and Slomiany, A. (1986). Changes in mucus glycoprotein synthesized in rat gastric mucosa exposed to ethanol. Biochem. Biophys. Acta 884: 1-10.
49. Tariq, M. and Aqeel, A.M. (1990). Gastric ulcer and cytoprotective effects of dipyridamole in rats. J. Pharmacol. Exp. Ther. 253: 946-949.
50. Valcavi, U., Caponi, R., Brambilla, A., Palmira, F., Minoja, F., Bernin, F., Mustani, R. and Fumagall, R. (1982). Gastric antisecretory, antiulcer and cytoprotective properties of 9-hydroxy-19,20-bis-norprostanoid acid in experimental animals. Arzneimittelforschung, 32: 657-663.
51. Wallace, J.L. and Whittle, B.J.R. (1986). Role of mucus in the repair of gastric epithelial damage in the rat. Gastroenterology 91: 603-611.
52. Wallace, J.L., McKnight, G.W., Keenan, C.M., Boyles, N.I.A. and MacNanghton, W.K. (1990). Effect of leukotrienes on susceptibility of the rat stomach to damage and investigation of the mechanism of action. Gastroenterology 98: 1178-1186.
53. Wallace, J.L. (1992). Non-steroidal anti-inflammatory drug gastropathy and cytoprotection: Pathogenesis and mechanisms re-examined. Scand. J. Gastroenterol. Suppl. 192: 3-8.
54. Weinberg, J.M., Nissim, I., Roeser, N.F., Davis, J.A., Schultz, S. and Nissim, I. (1991). Relationships between intracellular amino acid levels and protection against injury to isolated proximal tubules. Am. J. Physiol. 260: F410-F419.
55. Welsh, F., Sleet, R.B. and Greene, J.A. (1987). Attenuation of 2-methoxyethanol and methoxyacetic acid-induced digit malformations in mice by simple physiological compounds: Implications for the role of further metabolism of methoxyacetic acid in developmental toxicity. J. Biochem. Toxicol. 2: 225-240.
56. Williams, S.E. and Turnberg, L.A. (1980). Retardation of acid diffusion by pig gastric mucus: A potential role in mucosal protection. Gastroenterology 79: 299-304.
57. Yoshikawa, T., Naito, Y., Kishi, A., Tomii, T., Kaneko, T., Iinuma, S., Ichikawa, H., Yasuda, M., Takahashi, S. and Kondo, M. (1993). Role of reactive oxygen, lipid peroxidation and antioxidants in the pathogenesis of gastric mucosal injury induced by indomethacin in rats. Gut 34: 732-737.