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Volumn 53, Issue 6, 1997, Pages 594-600

Differential stability of proteolytically active and inactive recombinant metalloproteinase in Chinese hamster ovary cells

Author keywords

CHO; expression stability; mammalian cells; metalloproteinase; recombinant protein production

Indexed keywords

ASYMPTOTIC STABILITY; BIOTECHNOLOGY; CALCULATIONS; CELLS; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; MOLECULES; PRODUCTION; SURFACES;

EID: 1842301079     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19970320)53:6<594::AID-BIT7>3.0.CO;2-H     Document Type: Article
Times cited : (12)

References (42)
  • 1
    • 0025006860 scopus 로고
    • High levels of de nova methylation and altered chromatin structure at CpG islands in cell lines
    • Antequera, F., Boyes, J., Bird, A. 1990. High levels of de nova methylation and altered chromatin structure at CpG islands in cell lines. Cell 62: 503-514.
    • (1990) Cell , vol.62 , pp. 503-514
    • Antequera, F.1    Boyes, J.2    Bird, A.3
  • 2
    • 0029329234 scopus 로고
    • Stability of transfectomas producing chimeric antibody against the pre-S2 surface antigen of hepatitis B virus during long-term culture
    • Bae, S. W., Hong, H. J., Lee, G. M. 1995. Stability of transfectomas producing chimeric antibody against the pre-S2 surface antigen of hepatitis B virus during long-term culture. Biotechnol. Bioeng. 47: 243-251.
    • (1995) Biotechnol. Bioeng. , vol.47 , pp. 243-251
    • Bae, S.W.1    Hong, H.J.2    Lee, G.M.3
  • 3
    • 0024454057 scopus 로고
    • Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase
    • Bouvier, J., Bordier, C., Vogel, H., Reichelt, R., Etges, R. 1989. Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase Mol. Biochem. Parasitol. 37: 235-246.
    • (1989) Mol. Biochem. Parasitol. , vol.37 , pp. 235-246
    • Bouvier, J.1    Bordier, C.2    Vogel, H.3    Reichelt, R.4    Etges, R.5
  • 4
    • 0029046678 scopus 로고
    • Role of the Leishmania surface protease GP63 in complement fixation, cell adhesion, and resistance to compliment-mediated lysis
    • Brittingham, A., Morrison, C. J., McMaster, W. R., McGwire, B., Chang, K. P., Mosser, D. M. 1995. Role of the Leishmania surface protease GP63 in complement fixation, cell adhesion, and resistance to compliment-mediated lysis. J. Immunol. 155: 3102-3111.
    • (1995) J. Immunol. , vol.155 , pp. 3102-3111
    • Brittingham, A.1    Morrison, C.J.2    McMaster, W.R.3    McGwire, B.4    Chang, K.P.5    Mosser, D.M.6
  • 6
    • 0020624202 scopus 로고
    • DNA methylation and the regulation of globin gene expression
    • Busslinger, M., Hurst, J., Flavell, R. A. 1983. DNA methylation and the regulation of globin gene expression. Cell 34: 197-206.
    • (1983) Cell , vol.34 , pp. 197-206
    • Busslinger, M.1    Hurst, J.2    Flavell, R.A.3
  • 7
    • 0023837354 scopus 로고
    • Molecular cloning of the major surface antigen of Leishmania
    • Button, L. L., McMaster, W. R. 1988. Molecular cloning of the major surface antigen of Leishmania. J. Exp. Med. 167: 724-729.
    • (1988) J. Exp. Med. , vol.167 , pp. 724-729
    • Button, L.L.1    McMaster, W.R.2
  • 8
    • 0026032778 scopus 로고
    • Modification of GP63 genes from diverse species of Leishmania for expression of recombinant protein at high levels in Escherichia cpli
    • Button, L. L., Reiner, N. E., McMaster, W. R. 1991. Modification of GP63 genes from diverse species of Leishmania for expression of recombinant protein at high levels in Escherichia cpli. Mol. Biochem. Parasitol. 44: 213-224.
    • (1991) Mol. Biochem. Parasitol. , vol.44 , pp. 213-224
    • Button, L.L.1    Reiner, N.E.2    McMaster, W.R.3
  • 10
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid-guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski, P., Sacchi, N. 1987. Single-step method of RNA isolation by acid-guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 11
    • 0027112096 scopus 로고
    • Population balance between producing and nonproducing hybridoma clones is very sensitive to serum level, state of inoculum, and medium composition
    • Chuck, A. S., Palsson, B. O. 1992. Population balance between producing and nonproducing hybridoma clones is very sensitive to serum level, state of inoculum, and medium composition. Biotechnol. Bioeng. 39: 354-360.
    • (1992) Biotechnol. Bioeng. , vol.39 , pp. 354-360
    • Chuck, A.S.1    Palsson, B.O.2
  • 12
    • 0023195886 scopus 로고
    • Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: Evidence for derivation from a structure with four immunoglobulin-related domains
    • Clark, S. J., Jefferies, W. A., Barclay, A. N., Gagnon, J., Williams, A. F. 1987. Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc. Natl. Acad. Sci. USA 84: 1649-1653.
    • (1987) Proc. Natl. Acad. Sci. USA , vol.84 , pp. 1649-1653
    • Clark, S.J.1    Jefferies, W.A.2    Barclay, A.N.3    Gagnon, J.4    Williams, A.F.5
  • 13
    • 0027141144 scopus 로고
    • Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guerin expressing the Leishmania surface proteinase GP63
    • Connell, N. D., Medina-Acosta, H., McMaster, W. R., Bloom, B. R., Russell, D. G. 1993. Effective immunization against cutaneous leishmaniasis with recombinant bacille Calmette-Guerin expressing the Leishmania surface proteinase GP63. Proc. Natl. Acad. Sci. USA 90: 11473-11477.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 11473-11477
    • Connell, N.D.1    Medina-Acosta, H.2    McMaster, W.R.3    Bloom, B.R.4    Russell, D.G.5
  • 14
    • 0013391609 scopus 로고
    • Stability of amplified DNA in Chinese hamster ovary cells
    • R. E. Spier, J. B. Griffiths, and B. Meigner (eds.), Butterworth-Heinemann, Oxford
    • Cossons, N. H., Hayter, P. M., Tuite, M. F., Jenkins, N. 1991. Stability of amplified DNA in Chinese hamster ovary cells, pp. 309-314. In: R. E. Spier, J. B. Griffiths, and B. Meigner (eds.), Production of biologicals from animal cells in culture, Butterworth-Heinemann, Oxford.
    • (1991) Production of Biologicals from Animal Cells in Culture , pp. 309-314
    • Cossons, N.H.1    Hayter, P.M.2    Tuite, M.F.3    Jenkins, N.4
  • 15
    • 0015799158 scopus 로고
    • Somatic mutation and the origin of antibody diversity. Clonal variability of the immunoglobulin produced by MOPC 21 cells in culture
    • Cotton, R. H., Secher, D. S., Milstein, C. 1973. Somatic mutation and the origin of antibody diversity. Clonal variability of the immunoglobulin produced by MOPC 21 cells in culture. Eur. J. Immunol. 3: 135-140.
    • (1973) Eur. J. Immunol. , vol.3 , pp. 135-140
    • Cotton, R.H.1    Secher, D.S.2    Milstein, C.3
  • 16
    • 0029329201 scopus 로고
    • Relationship between loss of heavy chains and the appearance of nonproducing hybridomas
    • Couture, M. L., Heath, C. A. 1995. Relationship between loss of heavy chains and the appearance of nonproducing hybridomas. Biotechnol. Bioeng. 47: 270-275.
    • (1995) Biotechnol. Bioeng. , vol.47 , pp. 270-275
    • Couture, M.L.1    Heath, C.A.2
  • 17
    • 0023038374 scopus 로고
    • The major surface protein of Leishmania promastigotes is a protease
    • Etges, R., Bouvier, J., Bordier, C. 1986. The major surface protein of Leishmania promastigotes is a protease. J. Biol. Chem. 261: 9098-9101.
    • (1986) J. Biol. Chem. , vol.261 , pp. 9098-9101
    • Etges, R.1    Bouvier, J.2    Bordier, C.3
  • 18
    • 0025700415 scopus 로고
    • The loss of antibody productivity in continuous cultures of hybridoma cells
    • Frame, K. K., Hu, W. S. 1990. The loss of antibody productivity in continuous cultures of hybridoma cells. Biotechnol. Bioeng. 35: 469-476.
    • (1990) Biotechnol. Bioeng. , vol.35 , pp. 469-476
    • Frame, K.K.1    Hu, W.S.2
  • 19
    • 0026416428 scopus 로고
    • Kinetic study of hybridoma cell growth in continuous culture I. A model for non-producing cells
    • Frame, K. K., Hu, W. S. 1991. Kinetic study of hybridoma cell growth in continuous culture I. A model for non-producing cells. Biotechnol. Bioeng. 37: 55-64.
    • (1991) Biotechnol. Bioeng. , vol.37 , pp. 55-64
    • Frame, K.K.1    Hu, W.S.2
  • 20
    • 0022352450 scopus 로고
    • A quantitative stability analysis of human monoclonal antibody production by heteromyeloma hybridomas, using an immunofluorescent technique
    • Gardner, J. S., Chiu, A. L. H., Maki, N. E., Harris, J. F. 1985. A quantitative stability analysis of human monoclonal antibody production by heteromyeloma hybridomas, using an immunofluorescent technique. J. Immunol. Meth. 85: 335-346.
    • (1985) J. Immunol. Meth. , vol.85 , pp. 335-346
    • Gardner, J.S.1    Chiu, A.L.H.2    Maki, N.E.3    Harris, J.F.4
  • 22
    • 0025465324 scopus 로고
    • Methods for increasing monoclonal antibody production in suspension and entrapped cell cultures: Biochemical and flow cytometric analysis as a function of serum content
    • Heath, C., Dilwith, R., Belfort, G. 1990. Methods for increasing monoclonal antibody production in suspension and entrapped cell cultures: biochemical and flow cytometric analysis as a function of serum content. J. Biotechnol. 15: 71-90.
    • (1990) J. Biotechnol. , vol.15 , pp. 71-90
    • Heath, C.1    Dilwith, R.2    Belfort, G.3
  • 23
    • 0018085323 scopus 로고
    • Assignment of genes for immunoglobulin k and heavy chains to chromosome 6 and 12 in mouse
    • Hengartner, H., Tommaso, M., Muller, E. 1978. Assignment of genes for immunoglobulin k and heavy chains to chromosome 6 and 12 in mouse. Proc. Natl. Acad. Sci. USA 75: 4494-4498.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 4494-4498
    • Hengartner, H.1    Tommaso, M.2    Muller, E.3
  • 24
    • 0028224656 scopus 로고
    • Glycosylation of recombinant proteins: Problems and prospects
    • Jenkins, N., Curling, E. M. A. 1994. Glycosylation of recombinant proteins: problems and prospects. Enzyme Microb. Technol. 16: 354-364.
    • (1994) Enzyme Microb. Technol. , vol.16 , pp. 354-364
    • Jenkins, N.1    Curling, E.M.A.2
  • 25
    • 0022100495 scopus 로고
    • Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells
    • Kaufman, R. J., Wasley, L. C., Spiliotes, A. J., Gossels, S. D., Latt, S. A., Larsen, G. R., Kay, R. M. 1985. Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase sequences in Chinese hamster ovary cells. Mol. Cell Biol. 5: 1750-1759.
    • (1985) Mol. Cell Biol. , vol.5 , pp. 1750-1759
    • Kaufman, R.J.1    Wasley, L.C.2    Spiliotes, A.J.3    Gossels, S.D.4    Latt, S.A.5    Larsen, G.R.6    Kay, R.M.7
  • 26
    • 0028430190 scopus 로고
    • Stability of producer hybridoma cell lines after cell sorting: A case study
    • Kromenaker, S. J., Srienc, F. 1994. Stability of producer hybridoma cell lines after cell sorting: a case study. Biotechnol. Prog. 10: 299-307.
    • (1994) Biotechnol. Prog. , vol.10 , pp. 299-307
    • Kromenaker, S.J.1    Srienc, F.2
  • 27
    • 0025920324 scopus 로고
    • Applications of a population balance model to the loss of hybridoma antibody productivity
    • Lee, G. M., Varma, A., Palsson, B. O. 1991. Applications of a population balance model to the loss of hybridoma antibody productivity. Biotechnol. Prog. 7: 72-75.
    • (1991) Biotechnol. Prog. , vol.7 , pp. 72-75
    • Lee, G.M.1    Varma, A.2    Palsson, B.O.3
  • 28
    • 0028972393 scopus 로고
    • Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63
    • Macdonald, M. H., Morrison, C. J., McMaster, W. R. 1995. Analysis of the active site and activation mechanism of the Leishmania surface metalloproteinase GP63. Biochim. Biophys Acta. 1253: 199-207.
    • (1995) Biochim. Biophys Acta , vol.1253 , pp. 199-207
    • Macdonald, M.H.1    Morrison, C.J.2    McMaster, W.R.3
  • 29
    • 0027982197 scopus 로고
    • Mutational and functional analysis of the Leishmania surface metalloproteinase GP63: Similarities to matrix metalloproteinases
    • McMaster, W. R., Morrison, C. J., Macdonald, M. H., Joshi, P. 1994. Mutational and functional analysis of the Leishmania surface metalloproteinase GP63: similarities to matrix metalloproteinases. Parasitology 108: s29-s36.
    • (1994) Parasitology , vol.108
    • McMaster, W.R.1    Morrison, C.J.2    Macdonald, M.H.3    Joshi, P.4
  • 30
    • 0027607430 scopus 로고
    • Loss of antibody productivity is highly reproducible in multiple hybridoma subclones
    • Merritt, S. E., Palsson, B. O. 1993. Loss of antibody productivity is highly reproducible in multiple hybridoma subclones. Biotechnol. Bioeng. 42: 247-250.
    • (1993) Biotechnol. Bioeng. , vol.42 , pp. 247-250
    • Merritt, S.E.1    Palsson, B.O.2
  • 32
    • 0025305013 scopus 로고
    • Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum free media
    • Ozturk, S. S., Palsson, B. O. 1990. Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum free media. Hybridoma 9: 167-175.
    • (1990) Hybridoma , vol.9 , pp. 167-175
    • Ozturk, S.S.1    Palsson, B.O.2
  • 34
    • 0023669148 scopus 로고
    • Cell lineage ablation in transgenic mice by cell specific expression of a toxin gene
    • Palmiter, R. D., Behringer, R. R., Quaife, C. J., Maxwell, F., Maxwell, I., Brinster, R. 1987. Cell lineage ablation in transgenic mice by cell specific expression of a toxin gene. Cell 50: 435-443.
    • (1987) Cell , vol.50 , pp. 435-443
    • Palmiter, R.D.1    Behringer, R.R.2    Quaife, C.J.3    Maxwell, F.4    Maxwell, I.5    Brinster, R.6
  • 35
    • 1842352426 scopus 로고
    • Long-term stability of expression of humanised monoclonal antibody campath 1-H in Chinese hamster ovary cells
    • R. E. Spier, J. B. Griffiths, and C. MacDonald (eds.), Butterworth-Heinemann, Oxford
    • Raper, J., Douglas, Y., Gordon-Walker, N., Caulcott, C. A. 1992. Long-term stability of expression of humanised monoclonal antibody campath 1-H in Chinese hamster ovary cells, pp. 51-53. In: R. E. Spier, J. B. Griffiths, and C. MacDonald (eds.), Animal cell technology: developments, processes and products, Butterworth-Heinemann, Oxford-.Schimke, R. T. 1984. Gene amplification in cultured animal cells. Cell 37: 705-713.
    • (1992) Animal Cell Technology: Developments, Processes and Products , pp. 51-53
    • Raper, J.1    Douglas, Y.2    Gordon-Walker, N.3    Caulcott, C.A.4
  • 36
    • 0021735425 scopus 로고
    • Gene amplification in cultured animal cells
    • Raper, J., Douglas, Y., Gordon-Walker, N., Caulcott, C. A. 1992. Long-term stability of expression of humanised monoclonal antibody campath 1-H in Chinese hamster ovary cells, pp. 51-53. In: R. E. Spier, J. B. Griffiths, and C. MacDonald (eds.), Animal cell technology: developments, processes and products, Butterworth-Heinemann, Oxford-.Schimke, R. T. 1984. Gene amplification in cultured animal cells. Cell 37: 705-713.
    • (1984) Cell , vol.37 , pp. 705-713
    • Schimke, R.T.1
  • 37
    • 0008200829 scopus 로고
    • Isolation and expression of an altered dihydrofolate reductase cDNA
    • Simonsen, C. C., Levinson, A. D. 1983. Isolation and expression of an altered dihydrofolate reductase cDNA. Proc. Natl. Acad. Sci. USA 80: 2495-2499.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 2495-2499
    • Simonsen, C.C.1    Levinson, A.D.2
  • 38
    • 0013437532 scopus 로고
    • Population analysis of a recombinant Chinese hamster ovary cell line expressing recombinant human protein cultured in the presence and absence of methotrexate selective pressure
    • R. E. Spier, J. B. Griffiths and H. Borthold (eds.) Butterworth-Heinemann, Oxford
    • Sinacore, M. S., Brodeur, S., Brennan, S., Cohen, D., Fallon, M., Adamson, S. R. 1994. Population analysis of a recombinant Chinese hamster ovary cell line expressing recombinant human protein cultured in the presence and absence of methotrexate selective pressure, pp. 63-67. In: R. E. Spier, J. B. Griffiths and H. Borthold (eds.) Animal cell technology: products of today, prospects for tomorrow, Butterworth-Heinemann, Oxford.
    • (1994) Animal Cell Technology: Products of Today, Prospects for Tomorrow , pp. 63-67
    • Sinacore, M.S.1    Brodeur, S.2    Brennan, S.3    Cohen, D.4    Fallon, M.5    Adamson, S.R.6
  • 39
    • 0000457381 scopus 로고
    • Preparation of genomic DNA from mammalian tissue
    • F. M. Asubel et al. (eds.), Green Publishing/Wiley Interscience, New York
    • Strauss, W. M. 1987. Preparation of genomic DNA from mammalian tissue. In: F. M. Asubel et al. (eds.), Current protocols in molecular biology. Green Publishing/Wiley Interscience, New York.
    • (1987) Current Protocols in Molecular Biology
    • Strauss, W.M.1
  • 40
    • 0023931957 scopus 로고
    • Amplified expression constructs for human tissue-type plasminogen activator in Chinese hamster ovary cells: Instability in the absence of selective pressure
    • Weidle, U. H., Buckel, P. Wienberg, J. 1988. Amplified expression constructs for human tissue-type plasminogen activator in Chinese hamster ovary cells: instability in the absence of selective pressure. Gene 66: 193-203.
    • (1988) Gene , vol.66 , pp. 193-203
    • Weidle, U.H.1    Buckel, P.2    Wienberg, J.3
  • 41
    • 0021257801 scopus 로고
    • Improved fusion technique. II. Stability and purity of hybrid clones
    • Westerwoudt, R. J., Naipal, A. M., Harrison, C. M. H. 1984. Improved fusion technique. II. Stability and purity of hybrid clones. J. Immunol. Meth. 68: 89-101.
    • (1984) J. Immunol. Meth. , vol.68 , pp. 89-101
    • Westerwoudt, R.J.1    Naipal, A.M.2    Harrison, C.M.H.3
  • 42
    • 0018973063 scopus 로고
    • Analysis of immunoglobulin chain secretion using hybrid myelomas
    • Wilde, C. D., Milstein, C. 1980. Analysis of immunoglobulin chain secretion using hybrid myelomas. Eur. J. Immunol. 10: 462-467.
    • (1980) Eur. J. Immunol. , vol.10 , pp. 462-467
    • Wilde, C.D.1    Milstein, C.2


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