Maximum rate of oxygen uptake by human skeletal muscle in relation to maximal activities of enzymes in the Krebs cycle

Journal of Physiology

Volumn 501, Issue 2, 1997, Pages 455-460

  Blomstrand, Eva ^a   Rådegran, Göran ^a   Saltin, Bengt ^a  

^a University of Copenhagen   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CITRATE SYNTHASE; OXOGLUTARATE DEHYDROGENASE; OXYGEN; SUCCINATE DEHYDROGENASE;

ADULT; AEROBIC METABOLISM; ARTICLE; CITRIC ACID CYCLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; EXERCISE; EXTENSOR MUSCLE; FEMALE; FEMORAL ARTERY; FEMORAL VEIN; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; ILIAC BONE; KNEE; LEG BLOOD FLOW; MALE; MUSCLE BIOPSY; MUSCLE MASS; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE;

ADULT; BIOLOGICAL MARKERS; CITRATE (SI)-SYNTHASE; CITRIC ACID CYCLE; EXERCISE; FEMALE; HEXOKINASE; HUMANS; KETOGLUTARATE DEHYDROGENASE COMPLEX; LEG; MALE; MUSCLE, SKELETAL; ORGAN SIZE; OXYGEN CONSUMPTION; PHOSPHOFRUCTOKINASE-1; REGIONAL BLOOD FLOW; SUCCINATE DEHYDROGENASE;

EID: 1842296939     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.1997.455bn.x     Document Type: Article

References (23)

1. +-linked isocitrate dehydrogenase in muscle from vertebrates and invertebrates. Biochemical Journal 154, 689-700.
2. ANDERSEN, P., ADAMS, R. P., SJØGAARD, G., THORBOE, A. & SALTIN, B. (1985). Dynamic knee extension as model for study of isolated exercising muscle in humans. Journal of Applied Physiology 59, 1647-1653.
3. ANDERSEN, P. & SALTIN, B. (1985). Maximal perfusion of skeletal muscle in man. Journal of Physiology 366, 233-249.
4. ÅSTRAND, P.-O. & RODAHL, K. (1986). Textbook of Work Physiology, 3rd edn, pp. 543-547. McGraw-Hill, New York.
5. BALDWIN, K. M., WINDER, W. W., TERJUNG, R. L. & HOLLOSZY, J. O. (1973). Glycolytic enzymes in different types of skeletal muscle: adaptation to exercise. American Journal of Physiology 225, 962-966.
6. 2 deficit-debt relationship during exhaustive exercise in humans. Journal of Physiology 422, 539-559.
7. BERGSTRÖM, J. (1962). Muscle electrolytes in man. Scandinavian Journal of Clinical and Laboratory Investigation 14, suppl. 68, 1-110.
8. BLOMQVIST, C. G. & SALTIN, B. (1983). Cardiovascular adaptations to physical training. Annual Review of Physiology 45, 169-189.
9. BLOMSTRAND, E., CHALLISS, R. A. J., COONEY, G. J. & NEWSHOLME, E. A. (1983). Maximal activities of hexokinase, 6-phosphofructokinase, oxoglutarate dehydrogenase and carnitine palmitoyltransferase in rat and avian muscles. Bioscience Reports 3, 1149-1153.
10. BLOMSTRAND, E., EKBLOM, B. & NEWSHOLME, E. A. (1986). Maximum activities of key glycolytic and oxidative enzymes in human muscle from differently trained individuals. Journal of Physiology 381, 111-118.
11. COONEY, G. J., TAEGTMEYER, H. & NEWSHOLME, E. A. (1981). Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart. Biochemical Journal 200, 701-703.
12. MCALLISTER, R. M. & TERJUNG, R. L. (1991). Training-induced muscle adaptions: increased performance and oxygen consumption. Journal of Applied Physiology 70, 1569-1574.
13. NADESHDIN, W. A. (1932). Zur Untersuchung der Minderwertigkeit der Organe an Leichen. Deutsche Zeitschrift für die gesamte gerichtliche Medizine 18, 426-431.
14. NEWSHOLME, E. A., CRABTREE, B. & ZAMMIT, V. A. (1980) Use of enzyme activities as indices of maximum rates of fuel utilization. CIBA Foundation Symposium 73, 245-258.
15. NEWSHOLME, E. A. & LEECH, A. R. (1983). Biochemistry for the Medical Sciences, p. 145. John Wiley & Sons, Chichester, UK.
16. READ, G., CRABTREE, B. & SMITH, G. H. (1977). The activities of 2-oxoglutarate dehydrogenase and pyruvate dehydrogenase in hearts and mammary glands from ruminants and non-ruminants. Biochemical Journal 164, 349-355.
17. REICHMANN, H., HOPPELER, H., MATHIEU-COSTELLO, O., VON BERGEN, F. & PETTE, D. (1985). Biochemical and ultrastructural changes of skeletal muscle mitochondria after chronic electrical stimulation in rabbits. Pflügers Archiv 404, 1-9.
18. ROBINSON, D. M., OGILVIE, R. W., TULLSON, P. C. & TERJUNG, R. L. (1994). Increased peak oxygen consumption of trained muscle requires increased electron flux capacity. Journal of Applied Physiology 77, 1941-1952.
19. SALTIN, B. & GOLLNICK, P. (1983). Skeletal muscle adaptability: significance for metabolism and performance. In Handbook of Physiology, section 10, Skeletal Muscle, ed. PEACHEY, L. D., ADRIAN, R. H. & GEIGER, S. R., pp. 555-631. American Physiological Society, Bethesda, MD, USA.
20. SALTIN, B. & ROWELL, L. B. (1980). Functional adaptations to physical activity and inactivity. Federation Proceedings 39, 1506-1513.
21. SAVARD, G., KIENS, B. & SALTIN, B. (1987). Limb blood flow in prolonged exercise: magnitude and implication for cardiovascular control during muscular work in man. Canadian Journal of Sports Sciences 12 (suppl. 1), 89-101.
22. WEIBEL, E. R. & TAYLOR, C. R. (1981). Design of the mammalian respiratory system. Respiration Physiology 44, 1-164.
23. WIBOM, R. & HULTMAN, E. (1990). ATP production rate in mitochondria isolated from microsamples of human muscle. American Journal of Physiology 259, E204-209.