Gene conversion of major histocompatibility complex genes in the mouse spermatogenesis is a premeiotic event

Molecular Biology of the Cell

Volumn 8, Issue 12, 1997, Pages 2511-2517

  Högstrand, Kari ^a   Böhme, Jan ^a,b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b SÖDERTÖRN UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CELL TRANSFORMATION; GENE CONVERSION; GENE MUTATION; GENE SEGREGATION; GENE TRANSFER; GENETIC COMPLEMENTATION; GENETIC RECOMBINATION; MAJOR HISTOCOMPATIBILITY COMPLEX; MEIOSIS; MOUSE; NONHUMAN; PACHYTENE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SPERMATOCYTE; SPERMATOGENESIS;

ANIMALIA; EUKARYOTA;

EID: 1842293381     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.8.12.2511     Document Type: Article

References (36)

1. Baltimore, D. (1981). Gene conversion: some implications for immunoglobulin genes. Cell 24, 592-594.
2. Becker, R.S., and Knight, K.L. (1990). Somatic diversification of immunoglobulin heavy chain VDJ genes: evidence for somatic gene conversion in rabbits. Cell 63, 987-997.
3. Bellvé, A.R., Cavicchia, J.C., Milette, C.F., O'Brien, D.A., Bhatnagar, Y.M., and Dym, M. (1977). Spermatogenic cells of the prepubertal mouse. J. Cell Biol. 74, 68-85.
4. Clark, A.J., Chave-Cox, A., Ma, X., and Bishop, J.O. (1985). Analysis of mouse major urinary protein genes: variation between the exonic sequences of group 1 genes and a comparison with an active gene outwith group 1 both suggest that gene conversion has occurred between MUP genes. EMBO J. 4, 3167-3171.
5. De Robertis, E.D.P., and De Robertis, E.M.F., Jr. (1987). Meiosis and sexual reproduction, In: Cell and Molecular Biology, ed. E.D.P. De Robertis and E.M.F. De Robertis, Jr., Philadelphia: Lea & Febiger, 439-463.
6. Dorrington, J.H., and Fritz, I.B. (1974). Effects of gonadotropins on cyclic AMP production by isolated seminiferous tubule and interstitial cell preparations. Endocrinology 94, 395-403.
7. Edelman, G.M., and Gaily, J.A. (1968). Antibody structure, diversity and specificity. Brookhaven Symp. Biol. 21, 328-344.
8. Egorov, I.K., and Egorov, O.S. (1988). Detection of new MHC mutations by skin grafting, tumor transplantation and monoclonal antibodies: a comparison. Genetics 118, 287-298.
9. Geliebter, J., Zeff, R.A., Melvold, R.W., and Nathenson, S.G. (1986). Mitotic recombination in germ cells generated two major histocompatibility complex mutant genes shown to be identical by RNA analysis: Kbm9 and Kbm6. Proc. Natl. Acad. Sci. USA 83, 3371-3375.
10. Hecht, N.B. (1986). Regulation of gene expression during mammalian spermatogenesis. In: Experimental Approaches to Mammalian Embryonic Development, ed. J. Rossant and R.A. Pedersen, New York: Cambridge University Press, 151-193.
11. Heyting, C., Moens, P.B., van Raamsdonk, W., Dietrich, A.J.J., Vink, A.C.G., and Redeker, E.J.W. (1987). Identification of the two major components of the lateral elements of synaptonemal complexes of the rat. Eur. J. Cell. Biol. 43, 148-154.
12. Huang, M.M., Erlich, H.A., Goodman, M.F., and Arnheim, N. (1996). Analysis of mutational changes at the HLA locus in single human sperm. Hum. Mutat. 6, 303-310.
13. Högstrand, K., and Böhme, J. (1994). A determination of the frequency of gene conversion in unmanipulated mouse sperm. Proc. Natl. Acad. Sci. USA 91, 9921-9925.
14. Klein, J. (1984). Gene conversion in MHC genes. Transplantation 38, 327-329.
15. Kohn, H.I., Klein, J., Melvold, R.W., Nathenson, S.G., Pious, D., and Shreffler, D.C. (1978). The first H-2 mutant workshop. Immunogenetics 7, 279-294.
16. Letsou, A., and Liskay, R.M. (1987). Effect of the molecular nature of mutation on the efficiency of intrachromosomal gene conversion in mouse cells. Genetics 117, 759-769.
17. Liebhaber, S.A., Goossens, M., and Kan, Y.W. (1981). Homology and concerted evolution at the αl and α2 loci of human α-globin. Nature 290, 26-29.
18. Lowell, C.A., Potter, D.A., Stearman, R.S., and Morrow, J.F. (1986). Structure of the murine serum amyloid A gene family-gene conversion. J. Biol. Chem. 262, 8442-8452.
19. McIntyre, K.R., and Seidman, J.C. (1984). Nucleotide sequence of mutant I-Abm12 gene is evidence for genetic exchange between mouse immune response genes. Nature 308, 551-553.
20. Meistrich, M.L. (1977). Separation of spermatogenic cells and nuclei from rodent testes. In: Methods in Cell Biology, vol. 15, ed. D.M. Prescott, New York: Academic Press, 15-54.
21. Melvold, R.W., Kohn, H.I., and Dunn, G.R. (1982). History and genealogy of the H-2 Kb mutants from the C57BL/6Kh colony. Immunogenetics 15, 177-185.
22. Murti, J.A., Bumbulis, M., and Schimenti, J.C. (1992). High-frequency germ line gene conversion in transgenic mice. Mol. Cell. Biol. 22, 2545-2552.
23. Nairn, R., and Yamaga, K. (1980). Biochemistry of the gene products from murine MHC mutants. Ann. Rev. Genet. 24, 241-277.
24. Nebel, B.R., Amarose, A.P., and Hackett, E.M. (1961). Calendar of gametogenic development in the prepuberal mouse. Science 134, 832-833.
25. Oakberg, E.F. (1957). Duration of the spermatogenesis in the mouse. Nature (4595), 1137-1138.
26. Ohta, T. (1982). Allelic and nonallelic homology of a supergene family. Proc. Natl. Acad. Sci. USA 79, 3251-3254.
27. Pease, L.R., Schulze, D.H., Pfaffenbach, G.M., and Nathenson, S.G. (1983). Spontaneous H-2 mutants provide evidence that a copy mechanism analogous to gene conversion generates polymorphism in the major histocompatibility complex. Proc. Natl. Acad. Sci. USA 80, 242-246.
28. Radding, C. (1978). Meiotic gene conversion. Annu. Rev. Biochem. 47, 847-880.
29. Rothman, K.J. (1986). Analysis of crude data. In: Modern Epidemiology, ed. K.J. Rothman, Boston: Little, Brown and Co. 157-173.
30. Rubnitz, J., and Subramanti, S. (1986). Extrachromosomal and chromosomal gene conversion in mammalian cells. Mol. Cell. Biol. 6, 1608-1614.
31. Aγ-globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes. Cell 21, 627-638.
32. Spruill, W.A., White, M.G., Steiner, A.L., Tries, L.L., and Kireszenbaum, A.L. (1981). Temporal sequence of cell shape changes in cultured rat sertoli cells after experimental elevation of intracellular cAMP. Exp. Cell Res. 131, 131-148.
33. Weill, J.-C., and Reynaud, C.-A. (1996). Rearrangement/hypermutation/gene conversion: when, where and why? Immunol. Today 17, 92-97.
34. Weiss, E.H., Mellor, A., Golden, L., Fahrner, K., Simpson, E., Hurst, J., and Flavell, K.A. (1983). The structure of a mutant H-2 gene suggests that the generation of polymorphism in the H-2 genes may occur by gene conversion-like events. Nature 302, 671-674.
35. Willison, K.R. (1985). Sex and frequency of gene conversion in meiosis. Nature 313, 604.
36. Yeom, Y.I., Abe, K., Bennett, D., and Artzt, K. (1992). Testis-/ embryo-expressed genes are clustered in the mouse H-2 K region. Proc. Natl. Acad. Sci. USA 89, 773-777.