Flow cytometric cell sorting combined with molecular chimerism analysis to detect minimal recurrent leukemia: Good news and bad news

Bone Marrow Transplantation

Volumn 19, Issue 11, 1997, Pages 1157-1161

  Lamb Jr , L S ^a,d   Robbins, N F ^a   Abhyankar, S ^a   Joyce, M ^b   Stetler Stevenson, M ^c   Henslee Downey, P J ^a   Gee, A P ^a  

^a UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NEMOURS CHILDREN S CLINIC   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d Palmetto Richland Memorial Hospital   (United States)

Author keywords

Allogeneic bone marrow transplantation; Cell sorting; Flow cytometry; Minimal residual disease detection; Molecular chimerism analysis

Indexed keywords

ADOLESCENT; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CANCER RECURRENCE; CASE REPORT; CELL SELECTION; CHIMERA; DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; FEMALE; FLOW CYTOMETRY; HUMAN; LEUKEMIA; MINIMAL RESIDUAL DISEASE; PHENOTYPE; PRESCHOOL CHILD; PRIORITY JOURNAL; RELAPSE; TREATMENT FAILURE;

EID: 1842292128     PISSN: 02683369     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bmt.1700800     Document Type: Article

References (8)

1. Campana D, Pui C. Detection of minimal residual disease in acute leukemia: methodologic advances and clinical significance. Blood 1995; 85: 1416-1434.
2. Campana D, Coustan-Smith E, Behm FG. The definition of remission in acute leukemia with immunologic techniques. Bone Marrow Transplant 1991; 8: 429-437.
3. Scharf SJ, Smith AG, Hansen JA et al. Quantitative determination of bone marrow transplant engraftment using fluorescent polymerase chain reaction primers for human identity markers. Blood 1995; 85: 1954-1963.
4. Lamb LS, Parrish RS, Walker M et al. Peripheral lymphocyte reconstitution during the first year following bone marrow transplantation from a partially mismatched related donor. J Hematother 1995; 4: 239 (Abstr.).
5. Borowitz M, Guenther KL, Shults KE, Stelzer GT. Immunophenotyping of acute leukemias by flow cytometric analysis. Am J Clin Pathol 1993; 100: 534-540.
6. Verwer B, Terstappen LW. Automatic lineage assignment of acute leukemias by flow cytometry. Cytometry 1993; 14: 862-875.
7. Mackinnon S, Barnett L, Heller G, O'Reilly RJ. Minimal residual disease is more common in patients who have mixed T-cell chimerism after bone marrow transplantation for chronic myelogenous leukemia. Blood 1994; 83: 3409-3416.
8. Elmaagaeli AH, Becks HW, Beelen DW, Stockova J et al. Detection of minimal residual disease and persistence of host-type hematopoiesis: a study in 28 patients after sex-mismatched, non-T cell-depleted allogeneic bone marrow transplantation for Philadelphia-chromosome positive chronic myelogenous leukemia. Bone Marrow Transplant 16: 1995; 823-829.