Effect of tirilazad on brain nitric oxide synthase activity during cerebral ischemia in rats

Pharmacology

Volumn 54, Issue 2, 1997, Pages 108-112

  Del Pilar Fernandez Rodriguez, Maria ^a   Belmonte, Angel ^a   Meizoso, Maria Jose ^a   Garcia Novio, Manuel ^a   Garcia Iglesias, Elisardo ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Cerebral ischemia; Km; Nitric oxide synthase; Tirilazad; Vmax

Indexed keywords

AGENTS AFFECTING LIPID METABOLISM; ARGININE; CITRULLINE; NITRIC OXIDE SYNTHASE; OXYGEN RADICAL; SCAVENGER; TIRILAZAD; TRIMETAPHAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BRAIN CORTEX; BRAIN ISCHEMIA; BRAIN PROTECTION; CAROTID ARTERY OBSTRUCTION; CONTROLLED STUDY; ENZYME ACTIVITY; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 1842290970     PISSN: 00317012     EISSN: 14230313     Source Type: Journal    
DOI: 10.1159/000139476     Document Type: Article

References (31)

1. Bcnveniste H, Drchcr J. Schosboe A, Diemer NH: Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. J Neurochem 1984:43: 1369-1374.
2. Vcrrccchia C, Buisson A. Lakh-meche N. Plotkine M. Boulu RG: Nitric oxide and cerebral ischemia. Ann NY Acad Sci 1994:17:341-347.
3. Dawson VL, Dawson TM, London ED, Brent DS, Snyder SH: Nitric oxide mediates glutamate neurotoxicity in primary cortical culture. Proc Natl Acad Sci USA 1991;88: 6368-6371.
4. Kader A. Frazzini VI, Solomon RA, Trifiletti RR: Nitric oxide production during focal cerebral ischemia in rats. Stroke 1993:24:1709-1716.
5. Trifiletti RR: Neuroprotcctive effects ofN°-nitro-L-arginine in focal stroke in the 7-day-old rat. Eur J Pharmacol 1992;218:197-198.
6. o-Nitro-L-arginine protects against ischemia-induced increases in nitric oxide and hippocampal neuro-degeneration in the gerbil. Eur J Pharmacol 1994:260: 191-200.
7. Buisson A. Margaill I. Callebert J. Plotkine M. Boulu RG: Mechanisms involved in the neuroprotcctive activity of a nitric oxide synthase inhibitor during focal cerebral ischemia. J Neurochem 1993;61:690-696.
8. Buisson A. Plotkine M, Boulu RG: Inhibition of nitric oxide protects from cerebral ischemia in rats. Br.J Pharmacol 1992;106:766-767.
9. Zhang F, Xu S, ladecola C: Time dependence of effect of nitric oxide synthase inhibition of cerebral ischemic damage. J Cereb Blood Flow Metab 1995;15:595-601.
10. Siesjs BK: Pathophysiology and treatment of focal cerebral ischemia. J Neurosurg 1992:77:337-354.
11. Schurr A. Rigor BM: The mechanism of cerebral hvpoxic-ischaemic brain damage. Hippocampus 1992: 2:221-228.
12. Traystman RJ, Kirsch JR. Koehler RC: Oxygen radical mechanisms of brain injury following ischemia and reperfusion. J Appi Physiol 1991:71: 1185-1195.
13. Beckman JS. Beckman TW, Chen J. Marshall PA, Freeman BA: Apparent hydroxyl radical production by peroxy-nitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 1990:87:1620-1624.
14. Hall ED. Pazara KE. Braugghlcr JM: 21-Aminostcroid lipid peroxidation inhibitor U744006F protects against cerebral ischemia in gerbils. Stroke 1988:19:997-1002.
15. Hall ED, Yonkers PA: Attenuation of postischemic cerebral hypoperfusion by the 21-aminosteroid U74006F. Stroke 1988:19:340-344.
16. Belmonte A. Fernandez MP. Garcia M. Meizoso MJ, Beiras A, Sierra-Paredes G: Effect of 21-aminoste-roid U-74389G on neuron-specific enolasc in cerebral ischemia in the rat. Res Commun Biol Psychol Psychiatry 1995;20:7-18.
17. Smith ML, Auer RN. Siesjô BK: The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Ncurophathol (Berl) 1984:64: 319-332.
18. Bredt DS. Snyder SH: Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 1990:87:682-685.
19. Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976:72: 248-254.
20. Barjavel MC. Bhargava IIN: Nitric oxide synthase activity in brain regions and spinal cord of mice and rats: Kinetic analysis. Pharmacology 1995;50:168-174.
21. Sato S, Tominaga T. Ohnishi T. Ohnishi ST: Role of nitric oxide in brain ischemia. Ann NY Acad Sci 1994;17:369-373.
22. Kader A, Frazzini VI. Baker CJ. Solomon RA, Trifllelti RR: Effect of mild hypothermia on nitric oxide synthesis during focal cerebral ischemia. Neurosurgery 1994:35:272-277.
23. Pellegrini-Giampietro DE. Cherici G, Alesiani M. Carla V, Moroni F: Excitatory amino acid release and free radical formation may cooperate in genesis of ischemia-induced neuronal damage. J Neurosci 1990; 10:1035-1041.
24. Sakamoto A, Ohnishi ST, Ohnishi T. Ogawa R: Relationship between free radical production and lipid peroxidation during ischemia-reperfusion injury in the rat brain. Brain Res 1991;554:186-192.
25. Tomasi IZ. Grimaldi R. Vannini V, Agnati LF: Detection of free radicals during brain ischemia and reperfusion by spin trapping and microdialysis. Neurosci Lett 1992; 138:279-282.
26. Bred! DS, Ferris CD, Snyder SH: Nitric oxide synthase regulatory sites: Phosphorylation by cyclic AMP dependent protein kinase, protein kinase C, and calcium/cal-modulin protein kinase: Identification of flavin and calmodulin binding sites. J Biol Chem 1992:267: 10976-10981.
27. Schmidt HHHW, Pollock JS, Na-kane M. Gorsky LD. Forstermann U, Murad F: Purification of a soluble isoform of guanylyl cyclase-acti-vating-factor synthase. Proc Natl Acad Sci USA 1991:88:365-369.
28. Maruki Y, Koehler RC. Kirsch JR, Blizzard KK. Traystman RJ: Tirila-zad pretreatment improves early cerebral metabolic and blood flow recovery from hyperglycemic ischemia. J Cereb Blood Flow Mctab 1995;15:88-96.
29. Hall ED. Braughler JM. Yonkers PA. Smith SL. Linseman KL. Means ED, Schcrch HM, Von Voigtlander PF. Lahti RA, Jacobsen EJ: U-78517F: A potent inhibitor of lipid peroxidation with activity in experimental brain injury and ischemia. J Pharmacol ExpTher 1991:258:688-694.
30. Beck T. Bielenbcrg GW: The effects of two 21-aminosteroids on evert infarct size 48 hours after middle cerebral artery occlusion in the rat. Brain Res 1991:560:159-162.
31. Xue D, Slivka A. Buchan AM: Tiri-lazad reduces cortical infarction after transient but not permanent focal cerebral ischemia in rats. Stroke 1992:23:894-899.