The prediction of coronary atherosclerosis employing artificial neural networks

Clinical Cardiology

Volumn 23, Issue 6, 2000, Pages 453-456

  George, Jacob ^a   Ahmed, Alaa ^b   Patnaik, Madhumita ^b   Adler, Yehuda ^c   Levy, Yair ^a   Harats, Dror ^d   Gilburd, Boris ^a   Terrybery, Jeff ^b   Shen, Guo Qui ^b   Sagie, Alex ^c   Herz, Itzhak ^c   Snow, Peter ^e   Brandt, Jeff ^e   Peter, James ^b   Shoenfeld, Yehuda ^a,f  

^a Research Unit of Autoimmune Diseases   (Israel)

^b Specialty Laboratories   (United States)

^c RABIN MEDICAL CENTER   (Israel)

^d Lipid and Atherosclerosis Res Inst   (Israel)

^e Xaim Inc   (United States)

^f SHEBA MEDICAL CENTER   (Israel)

Author keywords

Anticardiolipin; Atherosclerosis; Autoimmunity; Infectious agents; Oxidized low density lipoprotein

Indexed keywords

C REACTIVE PROTEIN; HOMOCYSTEINE; OXIDIZED LOW DENSITY LIPOPROTEIN;

ADULT; AGED; ARTICLE; ARTIFICIAL NEURAL NETWORK; CHLAMYDOPHILA PNEUMONIAE; CORONARY ARTERY ATHEROSCLEROSIS; CYTOMEGALOVIRUS; DIABETES MELLITUS; FAMILY HISTORY; HELICOBACTER PYLORI; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OBESITY; SMOKING;

EID: 18344412903     PISSN: 01609289     EISSN: None     Source Type: Journal    
DOI: 10.1002/clc.4960230616     Document Type: Article

References (20)

1. Ross R: The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 1993;362:801-809
2. Wick G, Schett G, Amberger A, Kleindienst R, Xu Q: Is atherosclerosis an immunologically mediated disease? Immunol Today 1995;16:27-33
3. Libby P, Hansson GK: Involvement of the immune system in human atherogenesis: Current knowledge and unanswered questions. Lab Invest 1991;64:5-15
4. Witztum JL: The oxidation hypothesis of atherosclerosis. Lancet 1994;344:793-795
5. Salonen JT, Yia-Herttuala S, Yamamoto R, Butler S, Korpela H, Salonen R, Nyyssonen K, Palinski W, Witztum J: Antibodies against oxidized LDL and the progression of carotid atherosclerosis. Lancet 1992;339:883-887
6. Mendall MA, Patel P, Bellam L, Strachan D, Northfield TC: C-reactive protein and its relation to cardiovascular risk factors: A population based cross sectional study. Br Med J 1996;312:1061-1065
7. Ridker P, Cushman M, Stampfer M, Tracy R, Hennekens C: Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N Engl J Med 1997;336:973-979
8. Cook PJ, Lip GYH: Infectious agents and atherosclerotic vascular disease. Q J Med 1996;89:727-735
9. Libby P, Egan D, Skarlatos S: Roles of infectious agents in atherosclerosis and restenosis. Circulation 1997;96:4095-4103
10. Nicholson AC, Hajjar DP: Herpesviruses in atherosclerosis and thrombosis. Etiologic agents or ubiquitious bystandards? Arterioscler Tromb Vasc Biol 1998;18:339-348
11. CASS Principal Investigators and Associates: Coronary artery surgery study (CASS): A randomized trial of coronary artery bypass surgery. Circulation 1983;68:939-950
12. Principal Investigators of CASS and Associates: National Heart, Lung, and Blood Institute Coronary Artery Study 1. Circulation 1981;63(suppl 1):I-41-20
13. Araki A, Sako Y: Determination of free and total homocysteine in human plasma by high performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43-52
14. Gurfinkel E, Bozovich G, Daroca A, Beck E, Mautner B, for the ROXIS Study Group: Randomised trial of roxithromycine in non-Q wave coronary syndromes: ROXIS pilot study. Lancet 1997;350: 404-407
15. Puurunen M, Manttari M, Manninen V, Tenkanen L, Alfthan G, Ehnholm C, Vaarala O, Aho K, Paslosuo T: Antibodies against oxidized low density lipoprotein predicting myocardial infarction. Arch Intern Med 1994;154:2605-2609
16. Blank M, Cohen J, Toder V, Shoenfeld Y: Induction of anti-phospholipid syndrome in naive mice with lupus monoclonal and human polyclonal anti-cardiolipin antibodies. Proc Natl Acad Sci USA 1991;88:3069-3073
17. Vaarala O, Manttari M, Manninen V, Tenkanen L, Puurunen M, Aho K, Palosuo T: Anti-cardiolipin antibodies and risk of myocardial infarction in a prospective cohort of middle-aged men. Circulation 1995;91:23-27
18. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA: Antiphospholipid antibodies are directed against a complex antigen that includes a lipid binding inhibitor of coagulation: β2GPI (apolipoprotein H). Proc Natl Acad Sci USA 1990;87:4120-4124
19. George J, Afek A, Gilburd B, Levy Y, Blank M, Aron-Maor A, Shaish A, Levkovitz H, Goldberg I, Kopolovic J, Harats D, Shoenfeld Y: Induction of early atherosclerosis in LDL receptor deficient mice by immunization with beta 2 glycoproein I. Circulation (in press)
20. Lauerta P, Azen SP, LaBree L: Use of neural networks in predicting the risk of coronary artery disease. Comput Biomed Res 1995;28: 38-52