The effect of universal fluorinated nucleobases on the catalytic activity of ribozymes

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1347-1350

  Klopffer A E ^a   Engels, J W ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIFLUOROBENZENE DERIVATIVE; 4,6 DIFLUOROBENZIMIDAZOLE DERIVATIVE; BENZENE DERIVATIVE; IMIDAZOLE DERIVATIVE; NUCLEIC ACID BASE; RIBOZYME; UNCLASSIFIED DRUG;

CATALYSIS; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CONFERENCE PAPER; ENZYME MECHANISM; ENZYME STABILITY; ENZYME SUBSTRATE COMPLEX; FLUORINATION; HUMAN IMMUNODEFICIENCY VIRUS; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RETROVIRUS; SUBSTITUTION REACTION; SYNTHESIS;

BASE SEQUENCE; BENZIMIDAZOLES; CATALYSIS; FLUORINE; FLUOROBENZENES; KINETICS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RIBONUCLEOSIDES; RNA, CATALYTIC; SUBSTRATE SPECIFICITY;

FELIS CATUS; HUMAN IMMUNODEFICIENCY VIRUS; UNIDENTIFIED RETROVIRUS;

EID: 18344398207     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022962     Document Type: Conference Paper

References (7)

1. Parsch, J.; Engels, J.W. C-F⋯H-C Hydrogen bonds in ribonucleic acids. J. Am. Chem. Soc. 2002, 124 (20), 5664-5672.
2. Parsch, J.; Engels, J.W. Synthesis of fluorobenzene and benzimidazole nucleic-acid analogues and their influence on stability of RNA duplexes. Helv. Chim. Acta 2000, 83, 1791-1808.
3. Klöpffer, A.E.; Engels, J.W. Universal fluorinated nucleobases: Their effect on the catalytic activity of ribozymes. Coll. Symp. Series 2002, 5, 348-351.
4. Pitsch, S.; Weiss, P.A.; Jenny, L.; Stutz, A.; Wu, X. Reliable chemical synthesis of oligoribonucleotides (RNA) with 2′ -O-[(triisopropylsilyl)oxy]methyl(2′-O-tom)protected phosphoramidites. Helv. Chim. Acta 2001, 84, 3773-3795.
5. Hertel, K.; Uhlenbeck, O.; Eckstein, F.; Symons, R. Nucleic Acids Res. 1992, 20, 3252 pp.
6. Cuenoud, B; Huesken, D.; Martin, P.; Moser, H.E. Zweifache erkennung von doppelsträngiger DNA durch 2′-Aminoethoxy-modifizierte oligonucleotide. Angew. Chem. 1998, 110 (9), 1350-1353.
7. Mitsunobu, O. The use of diethyl azodicarboxylate and triphenylphosphine in synthesis and transformation of natural products. Synthesis 1981, 1-28.