Synthesis and biological activity of selective pipecolic acid-based TNF-α converting enzyme (TACE) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 10, 2002, Pages 1387-1390

  Letavic, Michael A ^a   Axt, Matt Z ^a   Barberia, John T ^a   Carty, Thomas J ^a   Danley, Dennis E ^a   Geoghegan, Kieran F ^a   Halim, Nadia S ^a   Hoth, Lise R ^a   Kamath, Ajith V ^a   Laird, Ellen R ^a   Lopresti Morrow, Lori L ^a   McClure, Kim F ^a   Mitchell, Peter G ^a   Natarajan, Vijayalakshmi ^a   Noe, Mark C ^a   Pandit, Jayvardhan ^a   Reeves, Lisa ^a   Schulte, Gayle K ^a   Snow, Sheri L ^a   Sweeney, Francis J ^a   Tan, Douglas H ^a   Yu, Chul H ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 BENZYLOXYBENZENESULFONAMIDE; ENZYME INHIBITOR; INTERSTITIAL COLLAGENASE; LIPOPOLYSACCHARIDE; PIPECOLIC ACID DERIVATIVE; SULFONAMIDE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA CONVERTING ENZYME INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOKINE RELEASE; DRUG ACTIVITY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN;

ADAM PROTEINS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; KINETICS; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPECOLIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 18344396963     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00183-X     Document Type: Article

References (15)