Use of parallel-synthesis combinatorial libraries for rapid identification of potent FKBP12 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 10, 2002, Pages 1421-1428

  Choi, Chi ^a   Li, Jia He ^a   Vaal, Mark ^a   Thomas, Christine ^a   Limburg, David ^a   Wu, Yong Qian ^a   Chen, Yi ^a   Soni, Raj ^a   Scott, Chad ^a   Ross, Douglas T ^a   Guo, Hong ^a   Howorth, Pamela ^a   Valentine, Heather ^a   Liang, Shi ^a   Spicer, Dawn ^a   Fuller, Mike ^a   Steiner, Joseph ^a   Hamilton, Gregory S ^a  

^a GUILFORD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; ENZYME INHIBITOR; FKBP12 INHIBITOR; IMMUNOPHILIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PIPECOLIC ACIDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TACROLIMUS BINDING PROTEIN 1A; UREA;

EID: 18344379671     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00147-6     Document Type: Article

References (13)