Influence of viral load and alanine aminotransferase on viral genetic heterogeneity in patients with chronic hepatitis C virus infection

Intervirology

Volumn 43, Issue 1, 2000, Pages 61-66

  Bozdayi, A Mithat ^a,b   Uzunalimoglu, Özden ^a   Aslan, Nuray ^a   Bozkaya, Hakan ^b   Türkyilmaz, Ahmet Resat ^a   Kayhan, Burhan ^c   Sahin, Tulay ^d   Sivri, Bulent ^c   Uygun, Ahmet ^e   Altiok, Aysin ^f   Çetinkaya, Hulya ^b   Karayalçin, Selim ^b   Yurdaydin, Cihan ^b  

^a Ankara Hepatology Institute   (Turkey)

^b ANKARA UNIVERSITY   (Turkey)

^c HACETTEPE UNIVERSITY   (Turkey)

^d TURKIYE YUKSEK IHTISAS HOSPITAL   (Turkey)

^e GULHANE SCHOOL OF MEDICINE   (Turkey)

^f Biotech Unit   (Turkey)

Author keywords

Alanine aminotransferase; Genotype; Hepatitis C virus; Quasispecies; Viral load

Indexed keywords

ALANINE AMINOTRANSFERASE; VIRUS RNA;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; DNA DETERMINATION; FEMALE; GENETIC HETEROGENEITY; GENOTYPE; HEPATITIS C; HUMAN; INFECTION; MALE; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SINGLE STRAND CONFORMATION POLYMORPHISM; VIRAL GENETICS; VIRUS IMMUNITY; VIRUS LOAD;

HEPATITIS C VIRUS;

EID: 18244428196     PISSN: 03005526     EISSN: None     Source Type: Journal    
DOI: 10.1159/000025024     Document Type: Article

References (21)

1. Farinati F, Fagiuoli S, De Maria N, Chiaramonte M, Aneloni V, Ongaro S, Salvagnini M, Naccarato R: Anti-HCV positive hepatocellular carcinoma in cirrhosis. Prevalence, risk factors and clinical features. J Hepatol 1992;14: 183-187.
2. Martell M, Esteban JI, Quer J, Genesca J, Weiner A, Esteban R, Guardia J, Gomez J: Hepatitis C virus (HCV) circulates as a population of different but closely related genomes: Quasispecies nature of HCV genome distribution. J Virol 1992;66:3225-3229.
3. Higashi Y, Kakumu S, Yoshioka K, Wakita T, Mizokami M, Ohba K, Ho Y, Ishikawa T, Takayanagi M, Nagai Y: Dynamics of genome change in the E2/NS1 region of hepatitis C virus in vivo. Virology 1993;197:659-668.
4. Koizumi K, Enomoto N, Kurosaki M, Murakami T, Izumi N, Marumo F, Sato C: Diversity of quasispecies in various disease stages of chronic hepatitis C virus infection and its significance in interferon treatment. Hepatology 1995;22:30-35.
5. Farci P, Alter HJ, Wong DC, Miller RH, Govindarajan S, Engle R, Shapiro M, Purcell RH: Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci USA 1994; 2:7792-7796.
6. Nakazawa T, Kato N, Ootsuyama Y, Sekiya H, Fujioka T, Shibuya A, Shimotohno K: Genetic alteration of the hepatitis C virus hypervariable region obtained from an asymptomatic carrier. Int J Cancer 1994;56:204-207.
7. Kanazawa Y, Hayashi N, Mita E, Li T, Hagiwara H, Kasahara A, Fusamato H, Kamada T: Influence of viral quasispecies on effectiveness of interferon therapy in chronic hepatitis C patients. Hepatology 1994;20:1121-1130.
8. Hayashi J, Kishihara Y, Yamaji K, Furusyo N, Yamamato T, Pac Y, Etoh Y, Ikemalsu Y, Kashiwagi T: Hepatitis C viral quasispecies and liver damage in patients with chronic hepatitis C virus infection. Hepatology 1997;25: 697-701.
9. Enomoto N, Kurosaki M, Tanaka Y, Marumo F, Sato C: Fluctuation of hepatitis C virus quasispecies in persistent infection and interferon treatment revealed by single-strand conformation polymorphism analysis. J Gen Virol 1994; 75:1361-1369.
10. Moribe T, Hayashi N, Kanazawa Y, Mita E, Fusamoto H, Negi M, Kaneshige T, Iqimi H, Kamada T, Uchida K: Hepatitis C viral complexity detected by single-strand conformation polymorphism and response to interferon therapy. Gastroenterology 1995;1083:789-795.
11. Chomczynski P, Sacchi N: Single step method of RNA isolation by acid-guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem 1984;162:156-159.
12. Chan SW, McOmish F, Holmes EC, Dow B, Peutherer JF, Follet E, Yap PL, Simmonds P: Analysis of a new hepatitis C virus type and its phylogenetic relationship to existing variants. J Gen Virol 1992;73:1131-1141.
13. Kurosaki M, Enomoto N, Marumo F, Sato C: Evolution and selection of hepatitis virus variants in patients with chronic hepatitis C virus. Virology 1994;205:161-169.
14. Zeuzem S, Schmidt JM, Lee JH, Rüster B, Roth WK: Effect of interferon alpha on the dynamics of hepatitis C virus turnover in vivo. Hepatology 1996;23:366-371.
15. Steinhauer DA, Holland J: Rapid evolution of RNA viruses. Annu Rev Microhiol 1987;41: 409-433.
16. Korenaga M, Hino K, Okazaki M, Okuda M, Okita K: Differences in hypervariable region 1 quasispecies between immune complexed and non-immune complexed hepatitis C virus particles. Biochem Biophys Res Commun 1997; 26:677-682.
17. Yuki N, Hayashi N, Moribe T, Matsushita Y, Tabata T, Inoue T, Kanazawa Y, Ohkawa K, Fusamato H, Kamada T: Relation of disease activity during chronic hepatitis C infection to complexity of hypervariable region 1 quasispecies. Hepatology 1997;25:439-444.
18. Kurosaki M, Enomoto N, Marumo F, Sato C: Rapid sequence variation of the hypervariable region of hepatitis C virus during the course of chronic infection. Hepatology 1993;18:1293-1299.
19. Naito M, Hayashi N, Moribe T, Hagiwara H, Mita E, Kanazawa Y, Kasahara A, Fusamato H, Kamada T: Hepatitis C viral quasispecies in hepatitis C virus carriers with normal liver enzymes and patients with type C chronic liver disease. Hepatology 1995;22:407-412.
20. Kumar U, Monjardino J, Thomas HC: Hypervariable region of hepatitis C virus envelope glycoprotein (E2/NS1) in an agammaglobulinemic patient. Gastroenterology 1994;106: 1072-1075.
21. Lawal Z, Petrik J, Wong VS, Alexander GJ, Allain JP: Hepatitis C viras genomic variability in untreated and immunosuppressed patients. Virology 1997;3:107-111.