Investigation of the role of the serotonergic activity of certain subtype-selective α1A antagonists in the relaxant effect on the pregnant rat uterus in vitro

Molecular Human Reproduction

Volumn 9, Issue 7-8, 2003, Pages 475-480

  Mihályi, Attila ^a   Ducza, Eszter ^a   Gáspár, Robert ^a   Falkay, George ^a  

^a UNIVERSITY OF SZEGED   (Hungary)

Author keywords

5 HT1A receptors; Alpha1A adrenoceptors; Rat; Tocolysis; Uterus

Indexed keywords

2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 METHYLURAPIDIL; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; MESSENGER RNA; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; RECEPTOR SUBTYPE; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTRIC FIELD; ELECTROSTIMULATION; FEMALE; GENE EXPRESSION; IN VITRO STUDY; MYOMETRIUM; NONHUMAN; PREGNANCY; PREMATURE LABOR; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONINERGIC SYSTEM; TOCOLYSIS; UTERUS CONTRACTION; UTERUS RELAXATION;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DIOXANES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRIC STIMULATION; FEMALE; MUSCLE RELAXATION; MYOMETRIUM; PIPERAZINES; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, ADRENERGIC, ALPHA-1; SEROTONIN; SEROTONIN ANTAGONISTS; UTERINE CONTRACTION;

ANIMALIA;

EID: 18244422117     PISSN: 13609947     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Albert, P.R., Zhou, Q.Y., Tol, H.H.M.V., Bunzow, J.R. and Civelli, O. (1989) Cloning, functional expression and mRNA tissue distribution of the rat 5-hydroxytryptamine1A receptor gene. J. Biol. Chem., 265, 5825-5832.
2. Althabe, F., Carroli, G., Lede, R., Belizan, J.M. and Althabe, O.H. (1999) Preterm delivery: detection of risks and preventive treatment. Rev. Panam. Salud. Publica, 5, 373-385.
3. 1-adrenoceptors on rabbit aorta. Eur. J. Pharmacol., 241, 141-148.
4. Chidlow, G., Cupido, A., Melena, J. and Osborne, N.N. (2001) Flesinoxan, a 5-HT1A receptor agonist/alpha 1-adrenoceptor antagonist, lowers intraocular pressure in NZW rabbits. Curr. Eye Res., 23, 144-153.
5. Chomczynski, P. and Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem., 162, 156-159.
6. 1A-adrenergic receptor in the contractility of the rat uterus post partum. Mol. Pharmacol., 59, 1235-1242.
7. Ducza, E., Gáspár, R. and Falkay, G. (2002) Altered levels of mRNA expression and pharmacological reactivity of alpha-1A adrenergic receptor subtypes in the late-pregnant rat myometrium. Mol. Reprod. Dev., 62, 343-347.
8. Eltze, M., Boer, R., Sanders, K.H. and Kolassa, N. (1991) Vasodilatation elicited by 5-HT1A receptor agonists in constant-pressure-perfused rat kidney is mediated by blockade of alpha 1A-adrenoceptors. Eur. J. Pharmacol., 202, 33-44.
9. Fletcher, A., Bill, D.J., Bill, S.J., Cliffe, I.A., Dover, G.M., Forster, E.A., Haskins, J.T., Jones, D., Mansell, H.L. and Reilly, Y. (1993a) WAY 100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur. J. Pharmacol., 237, 283-291.
10. Fletcher, A., Cliffe, I.A. and Dourish, C.T. (1993b) Silent 5-HT1A antagonists: utility as research tools and therapeutic agents. Trends Pharmacol. Sci., 14, 41-48.
11. 1-adrenoceptors. Life Sci., 68, 1119-1129.
12. Gross, G., Hanft, G. and Rugevics, C. (1988) 5-methylurapidil discriminates between subtypes of alpha1-adrenoceptor. Eur. J. Pharmacol., 151, 333-335.
13. Gross, G., Schuttler, K., Xin, X. and Hanft, G. (1990) Urapidil analogues are potent ligands of the 5-HT1A receptor. J. Cardiovasc. Pharmacol., 7, S8-S16.
14. Hieble, J.P., Bondinell, W. and Ruffolo, R.R. (1995) α and β-adrenoceptors: from the gene to the clinic. 1. Molecular biology and subclassification. J. Med. Chem., 38, 3415-3444.
15. Katz, V.L. and Farmer R.M. (1999) Controversies in tocolytic therapy. Clin. Obstet. Gynecol., 42, 802-819.
16. Lampert, M.B., Hibbard, J., Weinert, L., Briller, J., Lindheimer, M. and Lang, R.M. (1993) Peripartum heart failure associated with prolonged tocolytic therapy. Am. J. Obstet. Gynecol., 168, 493-495.
17. Legrand, C. and Maltier, J.P. (1986) Evidence for a noradrenergic transmission in the control of parturition in the rat. J. Reprod. Fertil., 76, 415-424.
18. Marshall, J.M. (1981) Effects of ovarian steroids and pregnancy on adrenergic nerves of uterus and oviduct. Am. J. Physiol., 240, C165-C174.
19. 1A-adrenoceptor antagonists in the tocolytic effect on pregnant rat uterus in vitro. Clin. Exp. Pharmacol. Physiol., 30, 164-167.
20. 3H-prazosin binding. Mol. Pharmacol., 29, 321-330.
21. Moser, P.C. (1991) The effect of putative 5-HT1A receptor antagonists on 8-OH-DPAT-induced hypothermia in rats and mice. Eur. J. Pharmacol., 193, 165-172.
22. Rosenberg, P. (2001) Tocolysis, use of beta-sympathomimetics for threatening preterm delivery: a critical review. J. Gynecol. Obstet. Biol. Reprod., 30, 221-230.
23. Schoeffter, P. and Hoyer, D. (1988) Centrally acting hypotensive agents with affinity for 5-HT1A binding sites inhibit forskolin-stimulated adenylate cyclase activity in calf hippocampus. Br. J. Pharmacol., 95, 975-985.
24. Scofield, M.A., Liu, F., Abel, P.W. and Jeffries, W.B. (1995) Quantification of steady state expression of mRNA for alpha-1 adrenergic receptor subtypes using reverse transcription and competitive polymerase chain reaction. J. Pharm. Exp. Ther., 275, 1035-1042.
25. Tso, J., Sun, X., Kao, T., Reece, K. and Wu, R. (1985) Isolation of rat and human glycerinaldehyde-3-phosphate dehydrogenase cDNA: genomic complexity and molecular evolution of the gene. Nucleic Acids Res., 13, 2485-2502.
26. Valenta, B. and Singer, E.A. (1990) Hypotensive effects of 8-hydroxy-2-(di-n-propylamino)tetralin and 5-methylurapidil following stereotaxic microinjection into the ventral medulla of the rat. Br. J. Pharmacol., 99, 713-716.
27. Zupkó, I., Gáspár, R., Kovács, L. and Falkay, G. (1997) Are α-adrenergic antagonists potent tocolytics? In vivo experiments on postpartum rats. Life Sci., 61, 159-163.