Topsentinols A-J, new sterols with highly branched side chains from marine sponge Topsentia sp.

Chemical and Pharmaceutical Bulletin

Volumn 45, Issue 9, 1997, Pages 1435-1435

  Ishibashi, Masami ^a   Yamagishi, Emiko ^a   Kobayashi, Jun'ichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

7 hydroxysterol; Antifungal activity; Sponge; Topsentia sp.; Topsentinol

Indexed keywords

ANTIFUNGAL AGENT; CHOLESTEROL DERIVATIVE; TOPSENTINOL; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SPONGE (PORIFERA); TRICHOPHYTON MENTAGROPHYTES;

EID: 18244418545     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.45.1435     Document Type: Article

References (8)

1. Giner J.-L., Chem. Rev., 93, 1735-1752 (1993).
2. D'Auria M. V., Minale L., Riccio R., Chem. Rev., 93, 1839-1896 (1993).
3. Kobayashi J., Ishibashi M., Heterocycles, 42, 943-970 (1996) and references cited therein.
4. Although compounds 7 and 8 were obtained as a mixture, their structures could be elucidated separately on the basis of comparison of the spectral data with those of closely related compounds such as 2 and 3, respectively.
5. Compound 12 was isolated from an Alcyonium sp. soft coral, while compound 11 was prepared by a known method: Kobayashi M., Kanda F., Damarla S. R., Rao D. V., Rao C. B., Chem. Pharm. Bull., 38, 2400-2403 (1990).
6. Li X., Djerassi C., Tetrahedron Lett., 24, 665-668 (1983).
7. Hofheinz W., Oesterhelt G., Helv. Chim. Acta, 62, 1307-1309 (1979).
8. The stereochemistry at the C-24 position of compounds 1, 3, 6, and 8 remains undefined.