Strychnine-induced epileptiform activity in hippocampal and neocortical slice preparations: Suppression by the organic calcium antagonists verapamil and flunarizine

Brain Research

Volumn 773, Issue 1-2, 1997, Pages 173-180

  Straub, H ^a   Kohling R ^a   Speckmann, E J ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Calcium antagonist; Calcium channel; Epilepsy; Strychnine; Verapamil Flunarizine

Indexed keywords

CALCIUM CHANNEL; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; FLUNARIZINE; STRYCHNINE; VERAPAMIL;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CALCIUM CURRENT; CONTROLLED STUDY; ELECTROSTIMULATION; EPILEPTIC DISCHARGE; FEMALE; GUINEA PIG; HIPPOCAMPUS; MALE; NEOCORTEX; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CALCIUM CHANNELS, L-TYPE; EPILEPSY; EVOKED POTENTIALS; FEMALE; FLUNARIZINE; GUINEA PIGS; HIPPOCAMPUS; MALE; NEOCORTEX; STRYCHNINE; VERAPAMIL;

EID: 18244413937     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00933-5     Document Type: Article

References (31)

1. Aicardi G., Schwartzkroin P.A. Suppression of epileptiform burst discharges in CA3 neurons of rat hippocampal slices by the organic calcium channel blocker, verapamil. Exp. Brain Res. 81:1990;288-296.
2. Bingmann D., Speckmann E.-J. Specific suppression of pentylenetetrazol-induced epileptiform discharges in CA3 neurons (hippocampal slice, guinea pig) by the organic calcium antagonists flunarizine and verapamil. Exp. Brain Res. 74:1989;239-248.
3. De Sarro G.B., Nistico G., Meldrum B.S. Anticonvulsant properties of flunarizine on reflex and generalized models of epilepsy. Neuropharmacology. 25:1986;695-701.
4. De Sarro G.B., De Sarro A., Trimarchi G.R., Nistico G. Effects of some calcium antagonists upon the activity of common antiepileptic compounds on sound-induced seizures in DBA/2 mice. Gen. Pharmacol. 23:1992;75-82.
5. Dolin S.J., Hunter A.B., Halsey M.J., Little H.J. Anticonvulsant profile of the dihydropyridine calcium channel antagonists, nitrendipine and nimodipine. Eur. J. Pharmacol. 152:1988;19-27.
6. C.L. Faingold, Seizures induced by convulsant drugs, in: P.C. Jobe, H.E. Laird (Eds.), Neurotransmitters and Epilepsy, Humana Press, Clifton, NJ, 1987, pp. 215-276.
7. Jones R.S.G., Heinemann U.H. Differential effects of calcium entry blockers on pre- and postsynaptic influx of calcium in the rat hippocampus in vitro. Brain Res. 416:1987;257-266.
8. M.R. Klee, T. Shirasaki, T. Nakaye, N. Akaike, E.N. Melikov, Interaction of strychnine and bicuculline with GABA- and glycine-induced chloride currents in isolated CA1 neurons, in: E.-J. Speckmann, M.J. Gutnick (Eds.), Epilepsy and Inhibition, Urban und Schwarzenberg, München, 1992, pp. 93-106.
9. Köhling R., Lehmenkühler A., Nicholson C., Speckmann E.-J. Superfusion of verapamil on the cerebral cortex does not suppress epileptic discharges due to restricted diffusion (rats, in vivo). Brain Res. 626:1993;149-155.
10. Köhling R., Straub H., Speckmann E.-J. Spontaneous and stimulus-triggered epileptic discharges: delayed antiepileptic effect with triggering. Exp. Brain Res. 100:1994;376-384.
11. Larkin J.G., Thompson G.G., Scobie G., Forrest G., Drennan J.E., Brodie M.J. Dihydropyridine calcium antagonists in mice: blood and brain pharmacokinetics and efficacy against pentylenetetrazol seizures. Epilepsia. 33:1992;760-769.
12. Lücke A., Speckmann E.-J. Influence of the organic calcium antagonist verapamil on N-methyl-D-aspartate (NMDA) induced cortical field potentials (neocortical slice, guinea pig). Neurosci. Lett. 161:1993;179-182.
13. Meyer F.B., Tally P.W., Anderson R.E., Sundt T.M. Jr., Yaksh T.L., Sharbrough F.W. Inhibition of electrically induced seizures by a dihydropyridine calcium channel blocker. Brain Res. 384:1986;180-183.
14. Moraidis I., Bingmann D., Lehmenkühler A., Speckmann E.-J. Caffeine-induced epileptic discharges in CA3 neurons of hippocampal slices of the guinea pig. Neurosci. Lett. 129:1991;51-54.
15. Morocutti C., Pierelli F., Sanarelli L., Stefano E., Peppe A., Mattioli G.L. Antiepileptic effects of a calcium antagonist (nimodipine) on cefazolin-induced epileptogenic foci in rabbits. Epilepsia. 27:1986;498-503.
16. Morris M.E. Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnesium Res. 5:1992;303-313.
17. O'Neill S.K., Bolger G.T. The effects of strychnine on the regulation of voltage-dependent calcium channels by dihydropyridines in brain and heart. Pharmacol. Biochem. Behav. 35:1990;833-840.
18. Pohl M., Straub H., Speckmann E.-J. Low magnesium-induced epileptiform discharges in guinea pig hippocampal slices: depression by the organic calcium antagonist verapamil. Brain Res. 577:1992;29-35.
19. Ramos J.G. On the mechanism of strychnine spikes. Acta Physiol. Am. Lat. 24:1974;125-133.
20. + levels in low magnesium induced epileptic activity (neocortical slices, guinea pig). Neuropharmacology. 33:1994;613-618.
21. E.-J. Speckmann, J. Walden, Antiepileptic effects of organic calcium channel blockers in animal experiments, in: P.A. Schwartzkroin (Ed.), Epilepsy: Models, Mechanisms, and Concepts, Cambridge University Press, 1993, pp. 462-486.
22. Spedding M., Paoletti R. Classification of calcium channels and the sites of action of drugs modifying channel function. Pharmacol. Rev. 44:1992;363-376.
23. Straub H., Speckmann E.-J., Bingmann D., Walden J. Paroxysmal depolarization shifts induced by bicuculline in CA3 neurons of hippocampal slices: suppression by the organic calcium antagonist verapamil. Neurosci. Lett. 111:1990;99-101.
24. + concentration. Comp. Biochem. Physiol. C. 103:1992;57-63.
25. Straub H., Lücke A., Köhling R., Moskopp D., Pohl M., Wassmann H., Speckmann E.-J. Low-magnesium-induced epileptiform activity in the human neocortex maintained in vitro: suppression by the organic calcium antagonist verapamil. J. Epilepsy. 5:1992;166-170.
26. Straub H., Köhling R., Speckmann E.-J. Picrotoxin-induced epileptic activity in hippocampal and neocortical slices (guinea pig): suppression by organic calcium channel blockers. Brain Res. 658:1994;119-126.
27. 2+ in neocortical tissue of epileptic and primary non-epileptic patients. Brain Res. 733:1996;307-311.
28. Straub H., Köhling R., Speckmann E.-J. Antiepileptic calcium antagonism in human and animal neocortical tissue. EEG-EMG-Z. 27:1996;226-235.
29. Walden J., Speckmann E.-J., Witte O.W. Suppression of focal epileptiform discharges by intraventricular perfusion of a calcium antagonist. Electroencephalogr. Clin. Neurophysiol. 61:1985;299-309.
30. Walden J., Speckmann E.-J. Suppression of recurrent generalized tonic-clonic seizure discharges by intraventricular perfusion of a calcium antagonist. Electroencephalogr. Clin. Neurophysiol. 69:1988;353-362.
31. Witte O.W., Speckmann E.-J., Walden J. Motor cortical epileptic foci in vivo: actions of calcium channel blocker on paroxysmal neuronal depolarizations. Electroencephalogr. Clin. Neurophysiol. 66:1987;43-55.