Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: A multicentre, randomised, double-blind, placebo-controlled study

Respiration

Volumn 70, Issue 3, 2003, Pages 275-283

  Górecka, Dorota ^a   Sliwinski P ^a   Palasiewicz G ^a   Pachocki, R ^b   Zielinski J ^a   Czajkowska Malinowska, M ^c   Ziolkowska Kochan M ^c   Superat, D ^c   Kubica, A ^c   Lisiecka, E ^c   Niebudek, S ^c   Moskal, W ^c   Dobrzanska J ^c   Zydok, M ^c   Papuzinski K ^c   Sporna, E ^c   Bogucki, A ^c   Jedrzejczak M ^c   Toporska Arendarska, B ^c   Filipowska, M ^c   Sokolowska L ^c   Sikora, A ^c   Szafranski W ^c   Czechowska, U ^c   Napieraj, B ^c   Nagrodkiewicz, K ^c   Malosek D ^c   Fabian, A ^c   Kislo A ^c   Izbicka, T ^c   Chatkowski, L ^c   Sobolewska, D ^c   Emeryk, B ^c   Strugalska, M ^c   Krzywiecki, A ^c   Kieda Szurkowska, J ^c   Pierzchala K ^c   Kaminski J ^c   Strzyga, P ^c   more..

^a NATIONAL TUBERCULOSIS AND LUNG DISEASES RESEARCH INSTITUTE   (Poland)

^b Servier Polska   (Poland)

^c NONE

Author keywords

Almitrine bismesylate; Chronic obstructive pulmonary disease; Moderate hypoxaemia; Twelve month study

Indexed keywords

ALMITRINE DIMESILATE; PLACEBO;

ABDOMINAL PAIN; ADULT; AGE; AGED; ANOREXIA; ARTERIAL BLOOD; ARTICLE; BILIARY TRACT DISEASE; BURNING SENSATION; CARBON DIOXIDE TENSION; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG FATALITY; FEMALE; FOLLOW UP; FORCED EXPIRATORY VOLUME; GAS EXCHANGE; GASTROINTESTINAL SYMPTOM; HEART ARRHYTHMIA; HEMATOLOGIC DISEASE; HUMAN; HYPOXEMIA; ISCHEMIC HEART DISEASE; LONG TERM CARE; MAJOR CLINICAL STUDY; MALE; MENTAL DISEASE; METABOLIC DISORDER; MULTICENTER STUDY; NEUROPATHY; NUTRITIONAL DISORDER; OXYGEN TENSION; PARESTHESIA; PERIPHERAL VASCULAR DISEASE; PNEUMONIA; POLYNEUROPATHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY FAILURE; SIDE EFFECT; TREATMENT OUTCOME; TREMOR; VERTIGO; WEIGHT REDUCTION;

AGED; ALMITRINE; ANOXEMIA; CARBON DIOXIDE; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; OXYGEN; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; PULMONARY GAS EXCHANGE; RESPIRATORY SYSTEM AGENTS;

EID: 18244413721     PISSN: 00257931     EISSN: None     Source Type: Journal    
DOI: 10.1159/000072009     Document Type: Article

References (41)

1. Feinleib M, Rosenberg HM, Collins JG, Delozier JE, Pokras R, Chevarley FM: Trends in COPD morbidity and mortality in the United States. Am Rev Respir Dis 1989;140:S9-S18.
2. World Health Organization: World Health Statistics Annual. 1995. Geneva, World Health Organization, 1995.
3. National Heart, Lung, and Blood Institute: Morbidity and Mortality: 1998 Chart Book on Cardiovascular, Lung, and Blood Diseases. Bethesda, US Department of Health and Human Services, Public Health Service, 1998.
4. Strassels S, Sullivan S, Smith D: Characterization of the costs of chronic obstructive pulmonary disease (COPD) in the US. Eur Respir J 1996;9(suppl 23):421s.
5. Long-term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1981;i:681-686.
6. Continuous or nocturnal oxygen therapy in hypoxemic chronic obstructive lung disease: A clinical trial. Nocturnal Oxygen Therapy Trial Group. Ann Intern Med 1980;93:391-398.
7. Górecka D, Gorzelak K, Śliwiński P, Tobiasz M, Zieliński J: Effect of long term oxygen therapy on survival in patients with chronic obstructive pulmonary disease with moderate hypoxaemia. Thorax 1997;52:674-679.
8. Veale D, Chailleux E, Taytard A, Cardinaud JP: Characteristics and survival of patients prescribed long-term oxygen therapy outside prescription guidelines. Eur Respir J 1998;12:780-784.
9. Dunne PJ: The demographics and economics of long-term oxygen therapy. Respir Care 2000;45:223-228.
10. Laubie M, Diot F: A pharmacological study of the respiratory stimulant action of S2620. J Pharmacol 1972;3:363-374.
11. Laubie M, Schmitt H: Long-lasting hyperventilation induced by almitrine: Evidence for a specific effect on carotid and thoracic chemoreceptors. Eur J Pharmacol 1980;61:125-136.
12. Melot C, Naeije R, Rotschild T, Mertens P, Mols P, Halleman R: Improvement in ventilation perfusion matching by almitrine in COPD. Chest 1983;83,528-533.
13. Hawryłkiewicz I, Jȩdrzejewska-Ma̧kowska M, Górecka D, Zieliński J: Effects of almitrine and oxygen on ventilation and gas exchange in patients with chronic respiratory insufficiency. Eur J Respir Dis 1983;64:512-516.
14. Voisin C, Howard P, Ansquer JC: Almitrine bismesylate. A long term placebo controlled double blind study in COAD. Vectarion International Multicentre Study Group. Bull Eur Physiopathol Respir 1987;23(suppl 11):169s-182s.
15. MacNee W, Connaughton JJ, Rhind GB, Hayhurst MD, Douglas NJ, Muir AL, Flenley DC: A comparison of the effects of almitrine or oxygen breathing on pulmonary arterial pressure and right ventricular ejection fraction in hypoxic chronic bronchitis and emphysema. Am Rev Respir Dis 1986;134:559-565.
16. Weitzenblum E, Schrijen F, Apprill M, Prefaut C, Yernault JC: One year treatment with almitrine improves hypoxaemia but does not increase pulmonary artery pressure in COPD patients. Eur Respir J 1991;4:1215-1222.
17. Allen MB, Prowse K: Peripheral nerve function in patients with chronic bronchitis receiving almitrine or placebo. Thorax 1989;44:292-297.
18. Gherardi R, Louarn F, Benvenuti C, Perrier M, Lejonc JL, Schaeffer A, Degos JD: Peripheral neuropathy in patients treated with almitrine bismesylate. Lancet 1985;i:1247-1250.
19. Bardsley PA, Howard P, Tang O, Empey D, Harrison B, Peake MD, O'Reilly J, Riordan JF, Wilkinson J, Arnaud F, Jarrat JA: Sequential treatment with low dose almitrine bismesylate in hypoxaemic chronic obstructive airways disease. Eur Respir J 1992;5:1054-1061.
20. Siafakas NM, Vermeire P, Pride NB, Paoletti P, Gibson J, Howard P, Yernault JC, Decramer M, Higenbottam T, Postma DS, Rees J on behalf of the Task Force: Optimal assessment and management of chronic obstructive pulmonary disease (COPD). A consensus statement of the European Respiratory Society. Eur Respir J 1995;8:1398-1420.
21. Standardization of spirometry, 1994 update. American Thoracic Society. Am J Respir Crit Care Med 1995;152:1107-1136.
22. Altose MD: Assessment and management of breathlessness. Chest 1985;88(2 suppl):77S-83S.
23. Zieliński J, Tobiasz M, Hawryłkiewicz I, Śliwiński P, Pałasiewicz G: Effects of long-term oxygen therapy on pulmonary hemodynamics in COPD patients. A 6-year prospective study. Chest 1998;113:65-70.
24. Weitzenblum E, Oswald M, Apprill M, Ratomaharo J, Kessler R: Evolution of physiologic variables in patients with chronic obstructive pulmonary disease before and during long-term oxygen therapy. Respiration 1991;58:126-131.
25. Dubois P, Jamart J, Machiels J, Smeets F, Lulling J: Prognosis of severely hypoxemic patients receiving long-term oxygen therapy. Chest 1994;105:469-474.
26. Chailleux E, Fauroux B, Binet F, Dauzenberg B, Polu J-M for the Observatory Group of ANTADIR: Predictors of survival in patients receiving domiciliary oxygen therapy or mechanical ventilation. A 10-year analysis of AN-TADIR Observatory. Chest 1996;109:741-749.
27. Aida A, Miyamoto K, Nishimura M, Aiba M, Kira S, Kawakami Y, the Respiratory Failure research group in Japan: Prognostic value of hypercapnia in patients with chronic respiratory failure during long-term oxygen therapy. Am J Respir Crit Care Med 1998;158:188-193.
28. Cooper CB, Howard P: An analysis of sequential physiologic changes in hypoxic cor pulmonale during long-term oxygen therapy. Chest 1991;100:76-80.
29. Arnaud F, Bertrand A, Charpin J, et al: Long-term almitrine bismesylate treatment in patients with chronic bronchitis and emphysema: A multicentre double-blind placebo controlled study. Eur J Respir Dis Suppl 1983;126:323-336.
30. Weitzenblum E, Arnaud F, Bignon J, Boutin C, Brune J, Castaing Y, Coutry G, Derenne J-P, Duroux P, Freour P, Muir JF, Paramelle B, Philip-Joet F, Poirier R, Pouget J, Senent J, Tonnel A: Administration sequentielle d'une posologie réduite d'almitrine à des malades BPCO. Rev Mal Respir 1992;9:455-463.
31. Castaing Y, Manier G, Varène N, Guénard H: Almitrine orale et distribution des rapports VA/Q dans les bronchopneumopathies chroniques obstructives. Bull Eur Physiopathol Respir 1981;17:917-932.
32. Melot C, Dechamps P, Hallemans R, Decroly P, Mols P: Enhancement of hypoxic pulmonary vasoconstriction by low dose almitrine bismesylate in normal humans. Am Rev Respir Dis 1989;139:111-119.
33. Pinet C, Tessonier F, Ravel T, Orehek J: Association of oral almitrine and medroxyprogesterone acetate: Effect on arterial blood gases in chronic obstructive pulmonary disease. Respir Med 2001;95:602-605.
34. 2 60-70 mm Hg. Lung 1990;168(suppl):770-775.
35. 2 desaturation and daytime pulmonary haemodynamics in COPD patients with mild hypoxaemia. Eur Respir J 1997;10:1730-1735.
36. Connaughton JJ, Douglas NJ, Morgan AD, Shapiro CM, Critchley JA, Pauly N, Flenley DC: Almitrine improves oxygenation both awake and asleep in patients with hypoxia and carbon dioxide retention caused by chronic bronchitis and emphysema. Am Rev Respir Dis 1985;132:206-210.
37. Zieliński J: Indications for long-term oxygen therapy: A reappraisal. Monaldi Arch Chest Dis 1999;54:178-182.
38. O'Donohue WJ Jr, Bowman TJ: Hypoxemia during sleep in patients with chronic obstructive pulmonary disease: Significance, detection, and effects of therapy. Respir Care 2000;45:188-191.
39. Saadjian AY, Phillip-Jöet FF, Barret A, Levy S, Arnaud AG: Effects of almitrine bismesylate on pulmonary vasoreactivity to hypoxia in chronic obstructive pulmonary disease. Eur Respir J 1994;7:862-868.
40. Winkelmann BR, Kullmer TH, Kneissl DG, Trenk D, Kronenberger H: Low-dose almitrine bismesylate in the treatment of hypoxaemia due to chronic obstructive pulmonary disease. Chest 1994;105:1383-1391.
41. Bardsley PA, Howard P, DeBacker W, Vermeire P, Mairesse M, Ledent C, Rademecker M, Bury T, Ansquer J: Two years treatment with almitrine bismesylate in patients with hypoxic chronic obstructive airways disease. Eur Respir J 1991;4:308-310.