Pyridoxine or pyridoxal phospate for intractable seizures?

Archives of Disease in Childhood

Volumn 90, Issue 5, 2005, Pages 441-442

  Baxter, P ^a  

^a SHEFFIELD CHILDREN S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACETAZOLAMIDE; ANTICONVULSIVE AGENT; BIOTIN; CARBAMAZEPINE; FOLINIC ACID; IMMUNOGLOBULIN; PYRIDOXAL 5 PHOSPHATE; PYRIDOXINE DERIVATIVE; STEROID; VALPROIC ACID; VIGABATRIN; VITAMIN; PYRIDOXINE;

ANOREXIA; APATHY; APNEA; BRAIN DISEASE; DIARRHEA; DISEASE EXACERBATION; DOSE RESPONSE; DROWSINESS; DRUG CHOICE; DRUG COST; DRUG DEPENDENCE; DRUG EFFICACY; GENERALIZED EPILEPSY; HUMAN; INTRACTABLE EPILEPSY; MAXIMUM TOLERATED DOSE; NEONATAL EPILEPTIC ENCEPHALOPATHY; PRIORITY JOURNAL; RESTLESSNESS; REVIEW; SENSORY NEUROPATHY; SIDE EFFECT; VOMITING; WEST SYNDROME; CHILD; DRUG RESISTANCE; NOTE; SEIZURE; TREATMENT OUTCOME;

ANTICONVULSANTS; CHILD; DRUG RESISTANCE; HUMANS; PYRIDOXAL PHOSPHATE; PYRIDOXINE; SEIZURES; TREATMENT OUTCOME;

EID: 18244408285     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.2004.052837     Document Type: Review

References (15)

1. Arzimanaglou A, Guerrini R, Aicardi J. Aicardi's epilepsy in children, 3rd edn. Philadelphia: Lippincott Williams & Wilkins, 2004:384.
2. Baxter P. Vitamin responsive conditions in paediatric neurology: a clinical approach. In: Baxter P, ed. Vitamin responsive conditions in paediatric neurology. International Review of Child Neurology Series. London: MacKeith Press, 2001:166-74.
3. Bender DA. Non-nutritional uses of vitamin B6. Br J Nutr 1999;89:7-20.
4. Clayton PT, Surtees RA, DeVile C, et al. Neonatal epileptic encephalopathy. Lancet 2003;361:1614.
5. Wang H-S, Kuo M-F, Chou M-L, et al. Pyridaxal phosphate is better than pyridoxine for controlling idiopathic intractable epilepsy. Arch Dis Child 2005;90:512-5.
6. Baxter P. Pyridoxine dependent and pyridoxine responsive seizures. In: Baxter P, ed. Vitamin responsive conditions in paediatric neurology. International Review of Child Neurology Series. London: MacKeith Press, 2001:109-65.
7. Ohtsuka Y, Ogino T, Asano T, et al. Long-term follow-up of vitamin B6-responsive West syndrome. Pediatr Neurol 2000;23:202-6.
8. Hrachovy RA, Frost JD Jr. Infantile epileptic encephalopathy with hypsarrhythmia (infantile spasms/West syndrome). J Clin Neurophysiol 2003;20:408-25.
9. Livingston S, Hsu JM, Petersen DC. Ineffectiveness of pyridoxine (vitamin B6) in the treatment of epilepsy. Pediatrics 1955;16:250-1.
10. Hagberg B, Hamfelt A, Hansson O. Tryptophan load tests and pyridoxal-5-phosphate levels in epileptic children. Acta Paediatr Scand 1966;55:371-84.
11. Hughes PAM, Bower BD, Raine DN, et al. Effect of treatment on the metabolism of tryptophan in childhood epilepsy. Arch Dis Child 1967;42:281-8.
12. Singh UK, Sinha RK. Pyridoxine dependent seizures. Indian Paediatrics 1996;33:121-3.
13. Jiao FY, Gao DY, Takuma Y, et al. Randomized, controlled trial of high-dose intravenous pyridoxine in the treatment of recurrent seizures in children. Pediatr Neurol 1997;17:54-7.
14. Ohtahara S, Yamatogi Y. Epileptic encephalopathies in early infancy with suppression-burst. J Clin Neurophysiol 2003;20:398-407.
15. Nakagawa E, Tanaka T, Ohno M, et al. Efficacy of pyridoxal phosphate in treating an adult with intractable status epilepticus. Neurology 1997;48:1468-9.