Large deformation finite element analysis of micropipette aspiration to determine the mechanical properties of the chondrocyte

Annals of Biomedical Engineering

Volumn 33, Issue 4, 2005, Pages 494-501

  Baaijens, Frank P T ^a   Trickey, Wendy R ^b   Laursen, Tod A ^c   Guilak, Farshid ^b  

^a EINDHOVEN UNIVERSITY OF TECHNOLOGY   (Netherlands)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c Duke University   (United States)

Author keywords

Biomechanics; Cartilage; Cytoskeleton; Nonlinear; Osteoarthritis; Poroelastic; Poroviscoelastic

Indexed keywords

CYTOSKELETON; NONLINEAR; OSTEOARTHRITIS (OA); POROELASTIC; POROVISCOELASTIC;

BIOMECHANICS; BOUNDARY CONDITIONS; CELLS; COMPUTER SIMULATION; DEFORMATION; DISEASES; ELASTIC MODULI; FINITE ELEMENT METHOD; MATHEMATICAL MODELS; MECHANICAL PROPERTIES; POISSON RATIO; STRAIN; TENSORS; VISCOELASTICITY;

CARTILAGE;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; BIOMECHANICS; CARTILAGE CELL; CELL CULTURE; COMPARATIVE STUDY; COMPUTER SIMULATION; CULTURE TECHNIQUE; CYTOLOGY; ELASTICITY; EVALUATION; FINITE ELEMENT ANALYSIS; HUMAN; MECHANICAL STRESS; MEMBRANE FLUIDITY; METHODOLOGY; MICROMANIPULATION; PHYSIOLOGY; PRESSURE; SURFACE PROPERTY; VACUUM; VISCOSITY;

ANIMALS; BIOMECHANICS; CAPILLARITY; CELL CULTURE TECHNIQUES; CELLS, CULTURED; CHONDROCYTES; COMPUTER SIMULATION; ELASTICITY; FINITE ELEMENT ANALYSIS; HUMANS; MEMBRANE FLUIDITY; MICROMANIPULATION; MODELS, BIOLOGICAL; PRESSURE; STRESS, MECHANICAL; VACUUM; VISCOSITY;

EID: 18244407509     PISSN: 00906964     EISSN: 15739686     Source Type: Journal    
DOI: 10.1007/s10439-005-2506-3     Document Type: Article

References (25)

1. Baaijens, F. An U-ALE formulation of 3-D unsteady viscoelastic flow. Int. J. Numer. Methods Eng. 36:1115-1143, 1993.
2. Bachrach, N., W. Valhmu, E. Stazzone, A. Ratcliffe, W. Lai, and V. Mow. Changes in proteoglycan synthesis of chondrocytes in articular cartilage are associated with the time-dependent changes in their mechanical environment. J. Biomech. 28:1561-1570, 1995.
3. Guilak, F. Compression-induced changes in the shape and volume of the chondrocyte nucleus. J. Biomech. 28:1529-1542, 1995.
4. Guilak, F., G. Erickson, and H. Ting-Beall. The effects of osmotic stress on the viscoelastic and physical properties of articular chondrocytes. Biophys. J. 82:720-727, 2002.
5. Guilak, F., and V. Mow. The mechanical environment of the chondrocyte: A biphasic finite element model of cell-matrix interactions in articular cartilage. J. Biomech. 33:1663-1673, 2000.
6. Guilak, F., R. L. Sah, and L. A. Setton. Physical Regulation of Cartilage Metabolism, In: Mow VC, Hayes W. C., Editors. Basic Orthopaedic Biomechanics. 2nd ed. Philadelphia: Lippincott-Raven; 1997, p. 179-207.
7. Haider, M., and F. Guilak. An axisymmetric boundary integral model for incompressible linear viscoelasticity: Application to the micropipette aspiration contact problem. J. Biomech. Eng. 122:236-244, 2000.
8. Haider, M., and F. Guilak. An axisymmetric boundary integral model for assessing elastic cell properties in the micropipette aspiration contact problem. J. Biomech. Eng. 124:586-595, 2002.
9. Hochmuth, R. Micropipette aspiration of living cells. J. Biomech. 33:15-22, 2000.
10. Hung, C., K. Costa, and X. Guo. Apparent and transient mechanical properties of chondrocytes during osmotic loading using triphasic theory and afm indentation. ASME Bioeng. Conf. BED-50:625-626, 2001.
11. Jones, W., H. Ting-Beall, G. Lee, S. Kelley, R. Hochmuth, and F. Guilak. Alterations in the young's modulus and volumetric properties of chondrocytes isolated from normal and osteoarthritic human cartilage. J. Biomech. 32:119-127, 1999.
12. Koay, E., A. Shien, and K. Athanasiou. Creep indentation of single cells. J. Biomech. Eng. 125(3):334-341, 2003.
13. Mow, V., S. Kuei, W. Lai, and C. Armstrong. Biphasic creep and stress relaxation of articular cartilage in compression: Theory and experiments. J. Biomech. Eng. 102:73-84, 1980.
14. Mow, V., D. Sun, X. Guo, C. Hung, and W. Lai. Chondrocyte-extracellular matrix interactions during osmotic swelling. ASME Bioeng. Conf. BED 42:133-134, 1999.
15. Poole, R. Imbalances of Anabolism and Catabolism of Cartilage Matrix Components in Osteoarthritis. In: Keuttner, K. E., Goldberg, V. M., eds. Osteoarthritic Disorders. AAOS Press, Rosemont, Illinois, USA, 1995, p. 247-260.
16. Sato, M., D. Theret, L. Wheeler, N. Ohshima, and R. Nerem. Application of the micropipette technique to the measurement of cultured porcine aortic endothelial cell viscoelastic properties. J. Biomech. Eng. 112:263-268, 1990.
17. Sengers, B., C. Oomens, and F. Baaijens. An integrated finite element approach to mechanics, transport and biosynthesis in tissue engineering. J. Biomech. Eng. 126:82-91, 2004.
18. Setton, L., W. Zhu, and V. Mow. The biphasic poroviscoelastic behavior of articular cartilage: Role of the surface zone in governing the compressive behavior. J. Biomech. 26:581-592, 1993.
19. Shin, D., and K. Athanasiou. Cytoindentation for obtaining cell biomechanical properties. J. Orthop. Res. 17:880-890, 1999.
20. Theret, D., M. Levesque, M. Sato, R. Nerem, and L. Wheeler. The application of a homogeneous half-space model in the analysis of endothelial cell micropipette measurements. J. Biomech. Eng. 110:190-199, 1988.
21. Trickey, W., F. Baaijens, T. Laursen, L. Alexopoulos, and F. Guilak. Determination of the Poisson's ratio of the cell: Recovery properties of chondrocytes after release from complete micropipette aspiration. J. Biomech. (Submitted), 2004a.
22. Trickey, W., G. Lee, and F. Guilak. Viscoelastic properties of chondrocytes from normal and osteoarthritic human cartilage. J. Orthop. Res. 18:891-898, 2000.
23. Trickey, W., T. Vail, and F. Guilak. The role of the cytoskeleton in the viscoelastic properties of human articular chondrocytes. J. Orthop. Res. 22:131-139, 2004b.
24. Wilkes, R., and K. Athanasiou. The intrinsic incompressibility of osteoblast-like cells. Tissue Eng. 2:167-181, 1996.
25. Wu, J., W. Herzog, and M. Epstein. Modelling of location- and time-dependent deformation of chondrocytes during cartilage loading. J. Biomech. 32:563-572, 1999.