Mixed-lipid storage disorder induced in macrophages and fibroblasts by oritavancin (LY333328), a new glycopeptide antibiotic with exceptional cellular accumulation

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 5, 2005, Pages 1695-1700

  Van Bambeke, Françoise ^a   Saffran, Jennifer ^a   Mingeot Leclercq, Marie Paule ^a   Tulkens, Paul M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CHOLESTEROL ESTER; ORITAVANCIN; OSMIUM; PHOSPHOLIPID; TEICOPLANIN; VANCOMYCIN;

ANIMAL CELL; ARTICLE; CELL VACUOLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ELECTRON MICROSCOPY; EMBRYO; EUKARYOTIC CELL; FIBROBLAST; LIPID STORAGE; LIPIDOSIS; LYSOSOME; MACROPHAGE; MICROSCOPY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-BACTERIAL AGENTS; CELL SURVIVAL; CHOLESTEROL; FIBROBLASTS; GLYCOPEPTIDES; LIPID METABOLISM; LYSOSOMAL STORAGE DISEASES; MACROPHAGES; MICE; MICROSCOPY, ELECTRON; PHOSPHOLIPIDS; RATS;

EID: 18244402385     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.5.1695-1700.2005     Document Type: Article

References (29)

1. al Nawas, B., and P. M. Shah. 1998. Intracellular activity of vancomycin and Ly333328, a new semisynthetic glycopeptide, against methicillin-resistant Staphylococcus aureus. Infection 26:165-167.
2. al Nawas, B., J. Swantes, and P. M. Shah. 2000. In vitro activity of LY333328, a new glycopeptide, against extracellular and intracellular vancomycin-resistant enterococci. Infection 28:214-218.
3. Casartelli, A., M. Bonato, P. Cristofori, F. Crivellente, G. Dal Negro, I. Masotto, C. Mutinelli, K. Valko, and V. Bonfante. 2003. A cell-based approach for the early assessment of the phospholipidogenic potential in pharmaceutical research and drug development. Cell Biol. Toxicol. 19:161-176.
4. Cooper, R. D., N. J. Snyder, M. J. Zweifel, M. A. Staszak, S. C. Wilkie, T. I. Nicas, D. L. Mullen, T. F. Butler, M. J. Rodriguez, B. E. Huff, and R. C. Thompson. 1996. Reductive alkylation of glycopeptide antibiotics: synthesis and antibacterial activity. J. Antibiot. (Tokyo) 49:575-581.
5. de Duve, C., and R. Wattiaux. 1966. Functions of lysosomes. Annu. Rev. Physiol. 28:435-492.
6. Hanai, J., J. Leroy, and J. S. O'Brien. 1971. Ultrastructure of cultured fibroblasts in I-cell disease. Am. J. Dis. Child. 122:34-38.
7. Kodavanti, U. P., and H. M. Mehendale. 1990. Cationic amphiphilic drugs and phospholipid storage disorder. Pharmacol. Rev. 42:327-354.
8. Kruth, H. S. 2001. Lipoprotein cholesterol and atherosclerosis. Curr. Mol. Med. 1:633-653.
9. Leroy, J. G., and J. W. Spranger. 1970. I-cell disease. N. Engl. J. Med. 283:598-599.
10. Lightbody, J., U. Wiesmann, B. Hadorn, and N. Herschkowitz. 1971. I-cell disease: multiple lysosomal-enzyme defect. Lancet i:451.
11. Lowry, O. H., N.J. Rosebrough, A. L. Farr, and R. J. Randall. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
12. Lullmann, H., R. Lullmann-Rauch, and O. Wassermann. 1978. Lipidosis induced by amphiphilic cationic drugs. Biochem. Pharmacol. 27:1103-1108.
13. Maderazo, E. G., S. P. Breaux, C. L. Woronick, R. Quintiliani, and C. H. Nightingale. 1988. High teicoplanin uptake by human neutrophils. Chemotherapy 34:248-255.
14. Matsuzawa, Y., and K. Y. Hosteller. 1980. Studies on drug-induced lipidosis: subcellular localization of phospholipid and cholesterol in the liver of rats treated with chloroquine or 4.4′-bis (diethylaminoethoxy)alpha, beta-diethyldiphenylethane. J. Lipid Res. 21:202-214.
15. Mingeot-Leclercq, M. P., and P. M. Tulkens. 1999. Aminoglycosides: nephrotoxicity. Antimicrob. Agents Chemother. 43:1003-1012.
16. Montenez, J. P., F. Van Bambeke, J. Piret, R. Brasseur, P. M. Tulkens, and M. P. Mingeot-Leclercq. 1999. Interactions of macrolide antibiotics (erythromycin A, roxithromycin, erythromycylamine [dirithromycin], and azithromycin) with phospholipids: computer-aided conformational analysis and studies on acellular and cell culture models. Toxicol. Appl. Pharmacol. 156:129-140.
17. Morris, J. A., and E. D. Carstea. 1998. Niemann-Pick C disease: cholesterol handling gone awry. Mol. Med. Today 4:525-531.
18. Neufeld, E. F., G. N. Sando, A. J. Garvin, and L. H. Rome. 1977. The transport of lysosomal enzymes. J. Supramol. Struct. 6:95-101.
19. Palmeri, S., C. Battisti, A. Malandrini, and A. Federico. 1995. Amiodarone induced lipidosis similar to Niemann-Pick C disease. Biochemical and morphological study. Life Sci. 57:1963-1971.
20. Reasor, M. J., and S. Kacew. 1996. An evaluation of possible mechanisms underlying amiodarone-induced pulmonary toxicity. Proc. Soc. Exp. Biol. Med. 212:297-304.
21. Serai, C., F. Van Bambeke, and P. M. Tulkens. 2003. Quantitative analysis of gentamicin, azithromycin, telithromycin, ciprofloxacin, moxifloxacin, and oritavancin (LY333328) activities against intracellular Staphylococcus aureus in mouse J774 macrophages. Antimicrob. Agents Chemother. 47:2283-2292.
22. Tabas, I. 2002. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J. Clin. Investig. 110:905-911.
23. Tulkens, P., A. Trouet, and F. Van Hoof. 1970. Immunological inhibition of lysosome function. Nature 228:1282-1285.
24. Tyteca, D., S. P. Van Der, M. Mettlen, F. Van Bambeke, P. M. Tulkens, M. P. Mingeot-Leclercq, and P. J. Courtoy. 2002. Azithromycin, a lysosomotropic antibiotic, has distinct effects on fluid-phase and receptor-mediated endocytosis, but does not impair phagocytosis in J774 macrophages. Exp. Cell Res. 281:86-100.
25. Tyteca, D., S. P. Van Der, F. Van Bambeke, K. Leys, P. M. Tulkens, P. J. Courtoy, and M. P. Mingeot-Leclercq. 2001. Azithromycin, a lysosomotropic antibiotic, impairs fluid-phase pinocytosis in cultured fibroblasts. Eur. J. Cell Biol. 80:466-478.
26. Van Bambeke, F., S. Carryn, C. Seral, H. Chanteux, D. Tyteca, M. P. Mingeot-Leclercq, and P. M. Tulkens. 2004. Cellular pharmacokinetics and pharmacodynamics of the glycopeptide antibiotic oritavancin (LY333328) in a model of J774 mouse macrophages. Antimicrob. Agents Chemother. 48: 2853-2860.
27. Van Bambeke, F., Y. Van Laethem, P. Courvalin, and P. M. Tulkens. 2004. Glycopeptide antibiotics: from conventional molecules to new derivatives. Pharmacological properties and clinical use. Drugs 64:913-936.
28. Van der Auwera, P., T. Matsumoto, and M. Husson. 1988. Intraphagocytic penetration of antibiotics. J. Antimicrob. Chemother. 22:185-192.
29. Yamamoto, A., S. Adachi, K. Ishikawa, T. Yokomura, and T. Kitani. 1971. Studies on drug-induced lipidosis. 3. Lipid composition of the liver and some other tissues in clinical cases of "Niemann-Pick-like syndrome" induced by 4,4′-diethylaminoethoxyhexestrol. J. Biochem. (Tokyo) 70:775-784.