Synthesis and anti-angiogenic activity of 6-(1,2,4-thiadiazol-5-yl)-3-amino pyridazine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 4, 2002, Pages 589-591

  Bongartz, Jean Pierre ^a   Stokbroekx, Raymond ^a   Van der Aa, Marcel ^a   Luyckx, Marcel ^a   Willems, Marc ^a   Ceusters, Marc ^a   Meerpoel, Lieven ^a   Smets, Gerda ^a   Jansen, Tine ^a   Wouters, Walter ^a   Bowden, Charlie ^a   Valletta, Lisa ^b   Herb, Mark ^b   Tominovich, Rose ^b   Tuman, Robert ^b  

^a JANSSEN RESEARCH FOUNDATION   (Belgium)

^b R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS INHIBITOR; PYRAZINE DERIVATIVE; PYRIDAZINE DERIVATIVE; THIADIAZOLE DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; EYE TOXICITY; GROWTH INHIBITION; IN VITRO STUDY; MALE; MICROVASCULATURE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; VASCULAR RING; ANIMAL; CAPILLARY; CULTURE TECHNIQUE; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; LEWIS CARCINOMA; METASTASIS; MOUSE; ORAL DRUG ADMINISTRATION; SYNTHESIS; WISTAR RAT;

ADMINISTRATION, ORAL; ANGIOGENESIS INHIBITORS; ANIMALS; CAPILLARIES; CARCINOMA, LEWIS LUNG; CULTURE TECHNIQUES; MALE; MICE; NEOPLASM METASTASIS; PYRIDAZINES; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 18244401678     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00805-8     Document Type: Article

References (9)