Synthesis and antibacterial activity of the 4-quinolone-3-carboxylic acid derivatives having a trifluoromethyl group as a novel n-1 substituent

Journal of Medicinal Chemistry

Volumn 48, Issue 9, 2005, Pages 3443-3446

  Asahina, Yoshikazu ^a   Araya, Ichiro ^a   Iwase, Kazuhiko ^a   Iinuma, Fujio ^a   Hosaka, Masaki ^a   Ishizaki, Takayoshi ^a  

^a KYORIN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 QUINOLONE 3 CARBOXYLIC ACID DERIVATIVE; 6 FLUORO 1 TRIFLUOROMETHYL 1,4 DIHYDRO 7 (4 METHYL 1 PIPERAZINYL) 4 OXO 3 QUINOLINECARBOXYLIC ACID; 7 (3 AMINO 1 PYRROLIDINYL) 6 FLUORO 1 TRIFLUOROMETHYL 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID; METHYL GROUP; NORFLOXACIN; QUINOLONE DERIVATIVE; TRIFLUOROMETHYL DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DESULFURIZATION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ESCHERICHIA COLI; FLUORINATION; NONHUMAN; OXIDATION; REACTION ANALYSIS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; CARBOXYLIC ACIDS; ESCHERICHIA COLI; MICROBIAL SENSITIVITY TESTS; PSEUDOMONAS AERUGINOSA; QUINOLONES; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE;

EID: 18244395578     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040204g     Document Type: Article

References (21)

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