SCOPUS 정보 검색 플랫폼

Volumn 10, Issue 4, 2002, Pages 975-988

Design and synthesis of a selective EP4-receptor agonist. Part 1: Discovery of 3,7-dithiaPGE1 derivatives and identification of their ω chains

(10) Maruyama, Toru a Asada, Masaki a Shiraishi, Tai a Ishida, Akiharu a Yoshida, Hideyuki a Maruyama, Takayuki a Ohuchida, Shuichi a Nakai, Hisao a Kondo, Kigen a Toda, Masaaki a

a ONO PHARMACEUTICAL CO (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3,7 DITHIA 16 PHENYL OMEGA NORPROSTAGLANDIN E1; 3,7 DITHIAPROSTAGALNDIN E1; CYCLIC AMP; ILOPROST; PROSTAGLANDIN E1 DERIVATIVE; PROSTAGLANDIN E2; PROSTAGLANDIN RECEPTOR; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CHO CELL; CONTROLLED STUDY; DRUG DESIGN; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN EXPRESSION; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

ALPROSTADIL; ANIMALS; CALCIUM; CHO CELLS; CRICETINAE; CYCLIC AMP; DRUG DESIGN; PROTEIN BINDING; RECEPTORS, PROSTAGLANDIN E; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES;

EID: 18244390525 PISSN: 09680896 EISSN: None Source Type: Journal
DOI: 10.1016/S0968-0896(01)00351-0 Document Type: Article

Times cited : (8)

References (17)

1
- 0028183018
- (1994) Pharmacol. Rev. , vol.46 , pp. 205
- Coleman, R.A.¹ Smith, W.L.² Narumiya, S.³

2
- 0008387550
- (1994) Prostaglandins , vol.47 , pp. 152
- Coleman, R.A.¹ Grix, S.P.² Head, S.A.³ Louttit, J.B.⁴ Mallett, A.⁵ Sheldrick, R.L.G.⁶

3
- 0032823306
- (1999) Physiol. Rev. , vol.79 , pp. 1193
- Narumiya, S.¹ Sugimoto, Y.² Ushikubi, F.³

4
- 0021861176
- (1985) Chem. Pharm. Bull. , vol.33 , pp. 2359
- Tanaka, T.¹ Okamura, N.² Bannai, K.³ Hazato, A.⁴ Sugiura, S.⁵ Manabe, K.⁶ Kamimoto, F.⁷ Kurozumi, S.⁸

5
- 0023738015
- (1988) J. Org. Chem. , vol.53 , pp. 5590
- Okamoto, S.¹ Kobayashi, Y.² Kato, H.³ Hori, K.⁴ Takahashi, T.⁵ Tsuji, J.⁶ Sato, F.⁷

6
- 0000346796
- 1H NMR analysis of (R)- and (S)-MTPA ester
- (1987) Tetrahedron Lett. , vol.28 , pp. 6351
- Kitano, Y.¹ Matsumoto, T.² Wakasa, T.³ Okamoto, S.⁴ Shimazaki, T.⁵ Kobayashi, Y.⁶ Sato, F.⁷ Miyaji, K.⁸ Arai, K.⁹

7
- 0030871070
- (1997) Br. J. Pharmacol. , vol.122 , pp. 217
- Kiriyama, M.¹ Ushikubi, F.² Kobayashi, T.³ Hirata, M.⁴ Sugimoto, Y.⁵ Narumiya, S.⁶

8
- 0015933662
- 2
- (1973) J. Org. Chem. , vol.38 , pp. 1250
- Hayashi, M.¹ Miyake, H.² Tanouchi, T.³ Iguchi, S.⁴ Iguchi, Y.⁵ Tanouchi, F.⁶

9
- 0008342897
- (a)17-(S)-Methyl moiety was used as the ω chain moiety of Limaprost and Ornoprostil. Drugs Future 1982, 7, 116.

10
- 0008301660
- (b)Drugs Future 1978, 3, 536.

11
- 0020643482
- 15-Cyclopentyl and 15-cyclohexyl derivatives were reported to exhibit potent inhibitory activity against platelet aggregation
- (1983) Prostaglandins, Leukotrienes, Med. , vol.11 , pp. 391
- Morley, J.¹ Page, C.P.² Paul, W.³ Mongelli, N.⁴ Cesarini, R.⁵ Gandorlfi, C.⁶

12
- 0008333953
- (b)ref 4.

13
- 0142082376
- (1980) Chem. Soc., Perkin Trans. 1 , pp. 495
- Caldwell, A.G.¹ Harris, C.J.² Stepney, R.³ Whittaker, N.J.⁴

14
- 0019182759
- 2 was reported to display a tissue-selective hypotensive profile:
- (1980) Prostaglandins , vol.20 , pp. 515
- Johnson, M.R.¹ Schaaf, T.K.² Constantine, J.W.³ Hess, H.J.⁴

15
- 0016434895
- 2 was often used as a selective EP1- and/or EP3-receptor agonist in the biological evaluation.
- (1975) Prostaglandins , vol.9 , pp. 9
- Miller, W.L.¹ Weeks, J.R.² Lauderdale, J.W.³ Kirton, K.T.⁴

16
- 0008394268
- A 16-phenoxy moiety was used as the ω chain moiety of Sulprostone. Drugs Future 1978, 3, 59.

17
- 0020622463
- A 16(R)-methyl-16(S)-hydroxy-15-deoxy moiety was used as the ω chain moiety of Misoprostol.
- (1983) J. Med. Chem. , vol.26 , pp. 786
- Collins, P.W.¹ Dajani, E.Z.² Pappo, R.³ Gasiecki, A.F.⁴ Bianchi, R.G.⁵ Woods, E.M.⁶

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.