Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablets

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 53, Issue 2, 2002, Pages 227-232

  Bettini, R ^a   Acerbi, D ^b   Caponetti, G ^c   Musa, R ^b   Magi, N ^b   Colombo, P ^a   Cocconi, D ^a   Santi, P ^a   Catellani, P L ^a   Ventura, P ^b  

^a UNIVERSITY OF PARMA   (Italy)

^b CHIESI FARMACEUTICI S P A   (Italy)

^c ALKERMES INC   (United States)

Author keywords

In vitro release; In vivo release; Parkinson's disease therapy; Release mechanism interaction; Three layer matrix

Indexed keywords

CARBIDOPA; LEVODOPA;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CROSSOVER PROCEDURE; DISSOLUTION; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; PARKINSON DISEASE; PHARMACOKINETICS; RANDOMIZED CONTROLLED TRIAL; SOLUBILITY; TABLET; TABLET DISINTEGRATION; VOLUNTEER;

ADMINISTRATION, ORAL; ANTIPARKINSON AGENTS; BIOLOGICAL AVAILABILITY; CARBIDOPA; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; DRUG DELIVERY SYSTEMS; HUMANS; LEVODOPA; PILOT PROJECTS; TABLETS, ENTERIC-COATED;

EID: 18244390275     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0939-6411(01)00238-7     Document Type: Article

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