Development of a highly selective EP2-receptor agonist. Part 2: Identification of 16-Hydroxy-17,17-trimethylene 9β-chloro PGF derivatives

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 4, 2002, Pages 1107-1114

  Tani, K ^a   Naganawa, A ^a   Ishida, A ^a   Egashira, H ^a   Sagawa, K ^a   Harada, H ^a   Ogawa, M ^a   Maruyama, T ^a   Ohuchida, S ^a   Nakai, H ^a   Kondo, K ^a   Toda, M ^a  

^a ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

9 DEOXY 9BETA CHLORO 15 DEOXY 16 HYDROXY 17,17 TRIMETHYLENE OMEGA NORPROSTAGLANDIN E2; CYCLIC AMP; PROSTAGLANDIN DERIVATIVE; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL MEMBRANE; CHO CELL; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STABILITY; DRUG SYNTHESIS; FEMALE; IN VITRO STUDY; INFRARED SPECTROPHOTOMETRY; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PREGNANCY; RAT; STRUCTURE ACTIVITY RELATION; UTERUS CONTRACTILITY;

ANIMALS; CHO CELLS; CRICETINAE; CYCLIC AMP; DRUG STABILITY; FEMALE; PREGNANCY; PROSTAGLANDINS F, SYNTHETIC; RADIOLIGAND ASSAY; RATS; RECEPTORS, PROSTAGLANDIN E; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; UTERINE CONTRACTION;

EID: 18244375052     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00370-4     Document Type: Article

References (18)