Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: Demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors

Life Sciences

Volumn 70, Issue 12, 2002, Pages 1427-1446

  Angeli, Piero ^a   Marucci, Gabriella ^a   Buccioni, Michela ^a   Piergentili, Alessandro ^a   Giannella, Mario ^a   Quaglia, Wilma ^a   Pigini, Maria ^a   Cantalamessa, Franco ^a   Nasuti, Cinzia ^a   Novi, Francesca ^b   Maggio, Roberto ^b   Qasem, Ahmed R ^c   Spampinato, Santi ^c  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Cardiac M2 receptors; Deoxamuscaroneoxime derivatives; Muscarinic subsite; Orthosteric and allosteric sites

Indexed keywords

DEMOX; MUSCARINIC AGENT; MUSCARINIC M2 RECEPTOR; MUSCARONE DERIVATIVE; OXIME DERIVATIVE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISSOCIATION CONSTANT; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG EFFECT; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG RESEARCH; GUINEA PIG; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE FIBER MEMBRANE; MALE; NONHUMAN; PROTEIN ISOLATION; RAT;

ALLOSTERIC REGULATION; ANIMALS; BINDING SITES; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; HEART ATRIA; MALE; MUSCARINE; MUSCARINIC AGONISTS; MYOCARDIAL CONTRACTION; OXIMES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

CAVIA PORCELLUS; SUS SCROFA;

EID: 18244370832     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(01)01521-1     Document Type: Article

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