FK506 aerosol locally inhibits antigen-induced airway inflammation in guinea pigs

International Archives of Allergy and Immunology

Volumn 136, Issue 4, 2005, Pages 372-378

  Morishita, Yoshihiko ^a   Hirayama, Yoshitaka ^a   Miyayasu, Kikuo ^a   Tabata, Kenji ^a   Kawamura, Akio ^a   Ohkubo, Yoshitaka ^a   Mutoh, Seitaro ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Airways; Asthma; Eosinophils; FK506; Guinea pigs; Interleukin 5

Indexed keywords

ANTIGEN; CYTOKINE; EOTAXIN; INTERLEUKIN 1BETA; INTERLEUKIN 5; INTERLEUKIN 5 ANTIBODY; MESSENGER RNA; OVALBUMIN; TACROLIMUS; ANTIBODY; IMMUNOSUPPRESSIVE AGENT;

AEROSOL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BLOOD; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG TISSUE LEVEL; EOSINOPHILIA; GENE EXPRESSION; GUINEA PIG; HEMOCONCENTRATION; IN SITU HYBRIDIZATION; INHALATION; INJECTION; LUNG; LUNG ALVEOLUS CELL; LUNG FLUID; LUNG LAVAGE; LYMPHOCYTE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROVOCATION TEST; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION; T LYMPHOCYTE ACTIVATION; TISSUE; ANIMAL; BIOSYNTHESIS; CHEMISTRY; EOSINOPHIL; GENETICS; IMMUNOLOGY; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; METABOLISM; RESPIRATORY SYSTEM;

ADMINISTRATION, INHALATION; ANIMALS; ANTIBODIES; BRONCHOALVEOLAR LAVAGE FLUID; CYTOKINES; EOSINOPHILS; GENE EXPRESSION; GUINEA PIGS; IMMUNOSUPPRESSIVE AGENTS; INFLAMMATION; INTERLEUKIN-5; MALE; RESPIRATORY SYSTEM; RNA, MESSENGER; TACROLIMUS;

EID: 18244368502     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000084257     Document Type: Article

References (31)

1. Larche M, Robinson DS, Kay AB: The role of T lymphocytes in the pathogenesis of asthma. J Allergy Clin Immunol 2003;111:450-463; quiz 464.
2. Bousquet J, Jeffery PK, Busse WW, Johnson M, Vignola AM: Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med 2000;161:1720-1745.
3. Walker C, Kaegi MK, Braun P, Blaser K: Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity. J Allergy Clin Immunol 1991;88:935-942.
4. Gleich GJ: Mechanisms of eosinophil-associated inflammation. J Allergy Clin Immunol 2000;105:651-663.
5. Sanderson CJ, Campbell HD, Young IG: Molecular and cellular biology of eosinophil differentiation factor (interleukin-5) and its effects on human and mouse B cells. Immunol Rev 1988;102:29-50.
6. Yamaguchi Y, Hayashi Y, Sugama Y, Miura Y, Kasahara T, Kitamura S, Torisu M, Mita S, Tominaga A, Takatsu K: Highly purified murine interleukin 5 (IL-5) stimulates eosinophil function and prolongs in vitro survival. IL-5 as an eosinophil chemotactic factor. J Exp Med 1988;167:1737-1742.
7. Leckie MJ, ten Brinke A, Khan J, Diamant Z, O'Connor BJ, Walls CM, Mathur AK, Cowley HC, Chung KF, Djukanovic R, Hansel TT, Holgate ST, Sterk PJ, Barnes PJ: Effects of an interleukin-5-blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response. Lancet 2000;356:2144-2148.
8. Flood-Page PT, Menzies-Gow AN, Kay AB, Robinson DS: Eosinophil's role remains uncertain as anti-interleukin-5 only partially depletes numbers in asthmatic airway. Am J Respir Crit Care Med 2003;167:199-204.
9. Kips JC, O'Connor BJ, Langley SJ, Woodcock A, Kerstjens HA, Postma DS, Danzig M, Cuss F, Pauwels RA: Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: A pilot study. Am J Respir Crit Care Med 2003;167:1655-1659.
10. Kino T, Hatanaka H, Miyata S, Inamura N, Nishiyama M, Yajima T, Goto T, Okuhara M, Kohsaka M, Aoki H, Imanaka H: FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro. J Antibiot (Tokyo) 1987;40:1256-1265.
11. Schreiber SL, Crabtree GR: The mechanism of action of cyclosporin A and FK506. Immunol Today 1992;13:136-142.
12. Rico MJ, Lawrence I: Tacrolimus ointment for the treatment of atopic dermatitis: Clinical and pharmacologic effects. Allergy Asthma Proc 2002;23:191-197.
13. Sengoku T, Sakuma S, Satoh S, Kishi S, Ogawa T, Ohkubo Y, Mutoh S: Effect of FK506 eye drops on late and delayed-type responses in ocular allergy models. Clin Exp Allergy 2003;33:1555-1560.
14. Norris AA, Jackson DM, Eady RP: Protective effects of cyclophosphamide, cyclosporin A and FK506 against antigen-induced lung eosinophilia in guinea-pigs. Clin Exp Immunol 1992;89:347-350.
15. Lapa e Silva JR, Ruffie C, Lefort J, Nahori MA, Vargaftig BB, Pretolani M: Prevention of antigen-induced bronchial hyperreactivity and airway inflammation in sensitized guinea-pigs by tacrolimus. Mediators Inflamm 1999;8:17-23.
16. Fukuda T, Akutsu I, Motojima S, Makino S: Inhibition of antigen-induced late asthmatic response and bronchial hyperresponsiveness by cyclosporin and FK 506. Int Arch Allergy Appl Immunol 1991;94:259-261.
17. Tamura K, Kobayashi M, Hashimoto K, Kojima K, Nagase K, Iwasaki K, Kaizu T, Tanaka H, Niwa M: A highly sensitive method to assay FK-506 levels in plasma. Transplant Proc 1987;19(suppl 6):23-29.
18. Minshall EM, Schleimer R, Cameron L, Minnicozzi M, Egan RW, Gutierrez-Ramos JC, Eidelman DH, Hamid Q: Interleukin-5 expression in the bone marrow of sensitized Balb/c mice after allergen challenge. Am J Respir Crit Care Med 1998;158:951-957.
19. Broide DH, Paine MM, Firestein GS: Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 1992;90:1414-1424.
20. Humbles AA, Conroy DM, Marleau S, Rankin SM, Palframan RT, Proudfoot AE, Wells TN, Li D, Jeffery PK, Griffiths-Johnson DA, Williams TJ, Jose PJ: Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: Analysis in a guinea pig model in vivo. J Exp Med 1997;186:601-612.
21. Ying S, Humbert M, Barkans J, Corrigan CJ, Pfister R, Menz G, Larche M, Robinson DS, Durham SR, Kay AB: Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1997;158:3539-3544.
22. Mould AW, Ramsay AJ, Matthaei KI, Young IG, Rothenberg ME, Foster PS: The effect of IL-5 and eotaxin expression in the lung on eosinophil trafficking and degranulation and the induction of bronchial hyperreactivity. J Immunol 2000;164:2142-2150.
23. Teran LM, Noso N, Carroll M, Davies DE, Holgate S, Schroder JM: Eosinophil recruitment following allergen challenge is associated with the release of the chemokine RANTES into asthmatic airways. J Immunol 1996;157:1806-1812.
24. Ying S, Meng Q, Zeibecoglou K, Robinson DS, Macfarlane A, Humbert M, Kay AB: Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and nonatopic (intrinsic) asthmatics. J Immunol 1999;163:6321-6329.
25. Mauser PJ, Pitman A, Witt A, Fernandez X, Zurcher J, Kung T, Jones H, Watnick AS, Egan RW, Kreutner W, Adams GK 3rd: Inhibitory effect of the TRFK-5 anti-IL-5 antibody in a guinea pig model of asthma. Am Rev Respir Dis 1993;148:1623-1627.
26. Hamelmann E, Oshiba A, Loader J, Larsen GL, Gleich G, Lee J, Gelfand EW: Antiinterleukin-5 antibody prevents airway hyperresponsiveness in a murine model of airway sensitization. Am J Respir Crit Care Med 1997;155:819-825.
27. Matsuo N, Shimoda T, Mitsuta K, Fukushima C, Matsuse H, Obase Y, Kohno S: Tacrolimus inhibits cytokine production and chemical mediator release following antigen stimulation of passively sensitized human lung tissues. Ann Allergy Asthma Immunol 2001;86:671-678.
28. Robinson D, Hamid Q, Bentley A, Ying S, Kay AB, Durham SR: Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma. J Allergy Clin Immunol 1993;92:313-324.
29. Andersson J, Nagy S, Groth CG, Andersson U: Effects of FK506 and cyclosporin A on cytokine production studied in vitro at a single-cell level. Immunology 1992;75:136-142.
30. Sakuma S, Higashi Y, Sato N, Sasakawa T, Sengoku T, Ohkubo Y, Amaya T, Goto T: Tacrolimus suppressed the production of cytokines involved in atopic dermatitis by direct stimulation of human PBMC system (comparison with steroids). Int Immunopharmacol 2001;1:1219-1226.
31. Wakugawa M, Hayashi K, Nakamura K, Tamaki K: Evaluation of mite allergen-induced Th1 and Th2 cytokine secretion of peripheral blood mononuclear cells from atopic dermatitis patients: Association between IL-13 and mite-specific IgE levels. J Dermatol Sci 2001;25:116-126.