Acute ischemic chest pain is not associated with increased calcitonin gene-related peptide (CGRP) levels in peripheral plasma nor in the coronary circulation

Scandinavian Cardiovascular Journal

Volumn 33, Issue 5, 1999, Pages 295-299

  Währborg, Peter ^a   Eliasson, Tore ^a   Edvardsson, Nils ^a   Ekman, Rolf ^b   Mannheimer, Clas ^a   Hedner, Thomas ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Acute myocardial infarction; Anginal pain; Calcitonin gene related peptide; Myocardial ischemia; Neuropeptides

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; LACTIC ACID; SUBSTANCE P;

ACUTE HEART INFARCTION; ADULT; AGED; ANGINA PECTORIS; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; COVARIANCE; EXTRACTION; FEMALE; HEART ATRIUM PACING; HEART MUSCLE; HEART MUSCLE ISCHEMIA; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN SECRETION; SENSORY NERVE CELL; SENSORY NERVE CONDUCTION;

AGED; ANGINA PECTORIS; CALCITONIN GENE-RELATED PEPTIDE; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA;

EID: 18144451581     PISSN: 14017431     EISSN: None     Source Type: Journal    
DOI: 10.1080/14017439950141551     Document Type: Article

References (26)

1. Bojsen-Moller F, Tranum-Jensen J. Wholemount demonstration of choliesterase-containing nerves in the right atrial wall, nodal tissue and atrioventricular bundle of the pig heart. J Anat 1971; 108: 375-376.
2. Clarke J. Perivascular peptides in the coronary circulation: relation to pathophysiology. In: Edvinsson L, Uddman R, editors. Vascular innervation and receptor mechanisms - New perspectives. San Diego: Academic Press Inc., Harcourt Brace Jovanovich, 1993: 369-371.
3. Coupe MO, Mak JCW, Yacoub M, Oldershaw PJ, Barnes PJ. Autoradiographic mapping of calcitonin gene-related peptide receptors in human and guinea pig hearts. Circulation 1990; 81: 741-747.
4. Edvinsson L, Ekman R, Jansen I, Ottosson A, Uddman R. Distribution, concentration, and effects of neuropeptide Y (NPY), vasoactive intestinal polypeptide (VIP), calcitonin gene-related peptide (CGRP) and substance P (SP) in human cerebral blood vessels. J Cereb Blood Flow Metab 1985a; 5 (Suppl 1): 545-546.
5. Edvinsson L, Håkanson R, Steen S, Sundler F, Uddman R, Wahlestedt C. Innervation of human omental arteries and veins and vasomotor responses to noradrenaline, neuropeptide Y, substance P and vasoactive intestinal peptide. Regul Pept 1985b; 12: 67-79.
6. Edvinsson L, Erlinge D, Hedner T, Hedner P, Thulin T, Valdemarsson S. Perivascular peptides (NPY, CGRP and SP) in hypertension and congestive heart failure. In: Edvinsson L, Uddman R, editors. Vascular innervation and receptor mechanisms - New perspectives. San Diego: Academic Press Inc., Harcourt Brace Jovanovich, 1993: 351-362.
7. Ehinger B, Fálck B, Persson H, Sporrong B. Adrenergic and cholinesterase-containing neurons in the heart. Histochemie 1968; 16: 197-205.
8. Forrester JS, Helfant RH, Pasternack A, et al. Atrial pacing in coronary heart disease. Am J Cardiol 1971; 27: 237-242.
9. Geisser S, Greenhouse S. An extension of Boxi's results on the use of the F distribution in multivariate analysis. Ann Math Stat 1976; 29: 885-891.
10. Hirsch EF, Nigh CA, Kaye MP, Cooper T. Terminal innervation of the heart. Arch Pathol 1964; 77: 172-187.
11. Ihlén H, Simonsen S, Vatne K. Reproducibility of ischemic lactate metabolism during atrial pacing in man. Cardiology 1983; 70: 177-183.
12. Lechleilner P, Genser N, Mair J, et al. Calcitonin gene-related peptide in patients with and without early reperfusion after acute myocardial infarction. Am Heart J 1992; 124: 1433-1439.
13. Ludman PF, Maseri A, Clark P, Davies JD. Effects of Calcitonin Gene-Related Peptide on normal and atheromatous vessels and on resistance vessels in the coronary circulation in humans. Circulation 1991; 84: 1993-2000.
14. Lundberg JM, Franco-Cereceda A, Hua X, Hökfelt T, Fischer JA. Coexistence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin. Eur J Pharmacol 1985; 108: 315-319.
15. McEwan JR, Larkin S, Davies G, et al. Calcitonin gene-related peptide: a potent dilator of human epicardial coronary arteries. Circulation 1986; 74: 1243.
16. McEwan JR, Benjamin N, Larkin S, Fuller RW, Dollery CT, MacIntyre I. Vasodilation by calcitonin gene-related peptide and substance P: a comparison of their effects on resistance and capacitance vessels of human forearms. Circulation 1988; 77: 1072-1080.
17. Morris JL, Gibbins IL, Campbell G, Murphy R, Furness JB, Costa M. Innervation of the large arteries and heart of the toad (Bufo Marinus) by adrenergic and peptide-containing neurons. Cell Tiss Res 1986; 243: 171-184.
18. Remme W. Myocardial lactate metabolism - The gold standard when evaluating interventions in ischemia. Eur Heart J 1992; 13(Suppl): 362.
19. Rosenfeld MG, Mermod JJ, Amara LW, et al. Production of a novel neuropeptide encoded by the calcitonin gene via tissue specific RNA processing. Nature 1983; 304: 129-133.
20. Sowton GE, Balcon R, Cross D, Frick MH. Measurement of the angina threshold using atrial pacing. Cardiovasc Res 1967; 1: 301-306.
21. Sylvén C. Angina pectoris. Clinical characteristics, neurophysiological and molecular mechanisms. Pain 1989; 36: 145-167.
22. Taguchi T, Karasaki H, Imamura T, Takasaki K. Endogenous Calcitonin Gene-Related Peptide mediates noradrenergic non-cholinergic depressor response to spinal cord stimulation in the pithed rat. Circ Res 1992; 71: 357-364.
23. Thadani U, Lewis J, Mathew T, West R, Parker J. Reproducibility of clinical and hemodynamic parameters during pacing stress testing in patients with angina pectoris. Circulation 1979; 60: 1036-1041.
24. Thom S, Hughes AD, Goldberg P, Martin G, Schachter M, Sever PS. The action of calcitonin gene-related peptide and vasoactive intestinal peptide as vasodilators in man in vivo and in vitro. Br J Clin Pharmacol 1987; 24: 139-144.
25. Uddman R, Edvinsson L, Ekblad E, Håkanson R, Sundler F. Calcitonin gene-related peptide (CGRP): perivascular distribution and vasodilatory effects. Regul Pept 1986; 15: 1-23.
26. Weihe E, Reinecke M, Forsmann WG. Distribution of vasoactive intestinal polypeptide-like immunoreactivity in the mammalian heart. Interrelation with neurotensin and substance P-like immunoreactive nerves. Cell Tiss Res 1984; 236: 527-540.