Volatile anesthetics alter protein stability

Toxicology Letters

Volumn 100-101, Issue , 1998, Pages 387-391

  Tanner, Jonathan W ^a   Liebman, Paul A ^a   Eckenhoff, Roderic G ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Differential scanning calorimetry; Protein stability; Volatile anesthetics

Indexed keywords

BOVINE SERUM ALBUMIN; HALOTHANE; HUMAN SERUM ALBUMIN; INHALATION ANESTHETIC AGENT; LYSOZYME; MYOGLOBIN; PANCREATIC RIBONUCLEASE; RIBONUCLEASE A;

CATTLE; CONFERENCE PAPER; DIFFERENTIAL SCANNING CALORIMETRY; DRUG MECHANISM; HEN; HORSE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN STABILITY; TEMPERATURE;

ANESTHETICS, INHALATION; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CATTLE; DRUG STABILITY; HALOTHANE; HUMANS; PROTEINS; THERMODYNAMICS;

BOVINAE; EQUUS CABALLUS;

EID: 18144445863     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-4274(98)00211-2     Document Type: Conference Paper

References (12)

1. Alifimoff, J.K., Miller, K.W., 1993. In: Rogers, M.C., Tinker, J.H., Covino, B.G., Longnecker, D.E. (Eds.), Principles and Practice of Anesthesiology. Mosby, St.Louis, MO, pp. 1034-1052.
2. Doig, A.J., Williams, D.H., 1992. Why water-soluble, compact, globular proteins have similar specific enthalpies of unfolding at 110°C. Biochemistry 31, 9371-9375.
3. 19F NMR study. Proc. Natl. Acad. Sci. USA 90, 6478-6482.
4. Eckenhoff, R.G., 1996. Amino-acid resolution of halothane binding sites in serum albumin. J. Biol. Chem. 271, 15521-15526.
5. Eckenhoff, R.G., Shuman, H., 1993. Halothane binding to soluble proteins determined by photoaffinity labeling. Anesthesiology 79, 96-106.
6. Franks, N.P., Lieb, W.R., 1984. Do general anaesthetics act by competitive binding to specific receptors? Nature 310, 599-601.
7. Gumpen, S., Hegg, P.O., Martens, H., 1979. Thermal stability of fatty acid-serum albumin complexes studied by differential scanning calorimetry. Biochim. Biophys. Acta 574, 189-196.
8. Johansson, J.S., Eckenhoff, R.G., Dutton, P.L., 1995. Binding of halothane to serum albumin demonstrated using tryptophan fluorescence. Anesthesiology 83, 316-324.
9. Privalov, G., Kavina, V., Freire, E., Privalov, P.L., 1995. Precise scanning calorimeter for studying thermal properties of biological macromolecules in dilute solution. Anal. Biochem. 232, 79-85.
10. Straume, M., Freire, E., 1992. Two-dimensional differential scanning calorimetry: simultaneous resolution of intrinsic protein structural energetics and ligand binding interactions by global linkage analysis. Anal. Biochem. 203, 259-268.
11. Ueda, I., Kamaya, H., 1973. Kinetic and thermodynamic aspects of the mechanism of general anesthesia in a model system of firefly luminescence in vitro. Anesthesiology 38, 425-436.
12. Ueda, I., Chiou, J.-S., Krishna, P.R., Kamaya, H., 1994. Specificity of anesthetic binding to proteins. Anesthesiology 81, A465.