Variations and constant patterns in eukaryotic MDR enzymes: Conclusions from novel structures and characterized genomes

Chemico-Biological Interactions

Volumn 130-132, Issue , 2001, Pages 491-498

  Jörnvall, Hans ^a   Shafqat, Jawed ^a   Persson, Bengt ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

ADH class emergence; Alcohol dehydrogenase; Completed eukaryotic genomes; Glutathione dependent formaldehyde dehydrogenase; Medium chain dehydrogenases reductases (MDR)

Indexed keywords

ALCOHOL DEHYDROGENASE;

CAENORHABDITIS ELEGANS; CONFERENCE PAPER; DROSOPHILA MELANOGASTER; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME STRUCTURE; EUKARYOTE; GENE DUPLICATION; GENOME; NONHUMAN; PHYLOGENY; PROTEIN FAMILY;

ALCOHOL DEHYDROGENASE; ALDEHYDE OXIDOREDUCTASES; ANIMALS; CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; GENE DUPLICATION; GENOME; PHYLOGENY; VERTEBRATES;

CAENORHABDITIS ELEGANS; DROSOPHILA MELANOGASTER; EUKARYOTA; MELANOGASTER; VERTEBRATA;

EID: 18144435137     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0009-2797(00)00294-5     Document Type: Conference Paper

References (12)

1. A super-family of medium-chain dehydrogenases/reductases (MDR). Sub-lines including ζ-crystallin, alcohol and polyol dehydrogenases, quinone oxidoreductases, enoyl reductases, VAT-1 and other proteins
2. Distinctive class relationships within vertebrate alcohol dehydrogenases
3. Fundamental molecular differences between alcohol dehydrogenase classes
4. Pea formaldehyde-active class III alcohol dehydrogenase: Common derivation of the plant and animal forms but not of the corresponding ethanol-active forms (classes I and P)
5. An ethanol-inducible MDR ethanol dehydrogenase/acetaldehyde reductase in Escherichia coli. Structural and enzymatic relationships to the eukaryotic protein forms
6. SDR and MDR: Completed genome sequences show these protein families to be large, of old origin, and of complex nature
7. Mycothiol-dependent formaldehyde dehydrogenase, a prokaryotic medium-chain dehydrogenase/reductase, phylogenetically links different eukaryotic alcohol dehydrogenases. Primary structure, conformational modelling and functional correlations
8. Amphioxus alcohol dehydrogenase: A class 3 form of single type and of structural conservation but with unique developmental expression
9. Class III alcohol dehydrogenase from Saccharomyces cerevisiae: Structural and enzymatic features differ toward the human/mammalian forms in a manner consistent with functional needs in formaldehyde detoxication
10. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
11. Involvement of alcohol dehydrogenase, short-chain dehydrogenase/reductase, aldehyde reductase, and cytochrome P450 in the construction of retinoid signaling by activation of retinoic acid synthesis
12. Crystal structure of sorbitol dehydrogenase