The defect in the metabolism of erythritol of the Brucella abortus B19 vaccine strain is unrelated with its attenuated virulence in mice

Vaccine

Volumn 16, Issue 17, 1998, Pages 1640-1645

  Sangari, Félix J ^a,c   Grilló, María J ^b   Jiménez De Bagüés, Mariá P ^b   González Carreró, Manuel I ^a   García Lobo, Juan M ^a   Blasco, José M ^b   Agüero, Jesús ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b Instituto Agroalimentario de Aragón IA2   (Spain)

^c Kuzell Institute for Arthritis and Infectious Diseases   (United States)

Author keywords

B19; Brucella abortus; Erythritol; Virulence in mice

Indexed keywords

BRUCELLA VACCINE; ERYTHRITOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL METABOLISM; BACTERIAL VIRULENCE; BRUCELLA ABORTUS; FEMALE; MOUSE; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL;

ANIMALS; BRUCELLA ABORTUS; ERYTHRITOL; FEMALE; MICE; MICE, INBRED BALB C; OXIDATION-REDUCTION; PHENOTYPE; VIRULENCE;

EID: 18144432737     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00063-2     Document Type: Article

References (35)

1. 1 Enright, F.M. The pathogenesis and pathobiology of Brucella infection in domestic animals. In: Animal Brucellosis, Nielsen, K. and Duncan, J.R. (Eds.) CRC Press, Boca Raton, 1990, pp. 301-320.
2. 2 Thoen, C.O. and Enright, F. Brucella. In: Pathogenesis of Bacterial Infections in Animals, Gyles, C.L. and Thoen, C.O. (Eds.). Iowa State University Press, Ames, 1986, pp. 160-171.
3. 3 Keppie, J., Williams, A.E., Witt, K. and Smith, H. The role of erythritol in the tissue localization of the Brucellae. Br. J. Exp. Pathol. 1965, 46, 104-108.
4. 4 Pearce, J.H., Williams, A.E., Harris-Smith, P.W., Fitzgeorge, R.B. and Smith, H. The chemical basis of the virulence of Brucella abortus. II. Erythritol, a constituent of bovine foetal fluids which stimulates the growth of Brucella abortus in bovine phagocytes. Br. J. Exp. Pathol. 1962, 43, 31-36.
5. 5 Smith, H., Keppie, J., Pearce, J.H., Fuller, R. and Williams, A.E. The chemical basis of the virulence of Brucella abortus. I. Isolation of Brucella abortus for bovine foetal tissue. Br. J. Exp. Pathol. 1961, 42, 631-636.
6. 6 Smith, H., Williams, A.E., Keppie, J., Harris-Smith, P.W., Fitzgeorge, R.B. and Witt, K. Foetal erythritol: a cause of the localization of Brucella abortus in bovine contagious abortion. Nature 1962, 193, 47-49.
7. 7 Sperry, J.A. and Robertson, D.C. Erythritol catabolism by Brucella abortus. J. Bacteriol. 1975, 121, 619-630.
8. 8 Williams, A.E., Keppie, J. and Smith, H. The chemical basis of virulence of Brucella abortus. III. Foetal erythritol a cause of the localization of Brucella abortus pregnant cows. Br. J. Exp. Pathol. 1962, 43, 530-536.
9. 9 Brown, G.M., Love, E.L., Pietz, D.E. and Ranger, C.R. Characterization of Brucella abortus strain 19. Am. J. Vet. Res. 1972, 33, 759-764.
10. 10 Nicoletti, P. Prevalence and persistence of Brucella abortus strain 19 infections and prevalence of other biotypes in vaccinated adult dairy cattle. Am. J. Vet. Res. 1981, 178, 143-145.
11. 11 Alton, G.G., Corner, L.A. and Plackett, P. Vaccination of pregnant cows with low doses of Brucella abortus strain 19 vaccine. Aust. Vet. J. 1980, 56, 369-372.
12. 12 Beckett, F.W. and MacDiarmid, S.C. The effect of reduced-dose Brucella abortus strain 19 vaccination in accredited dairy herds. Br. Vet. J. 1985, 141, 507-514.
13. 13 Corner, L.A. and Alton, G.G. Persistence of Brucella abortus strain 19 infection in adult cattle vaccinated with reduced doses. Res. Vet. Sci. 1981, 31, 342-344.
14. 14 Sangari, F.J. and Agüero, J. Identification of Brucella abortus B19 vaccine strain by the detection of DNA polymorphism at the ery locus. Vaccine 1994, 12, 435-438.
15. 15 Sangari, F.J., García-Lobo, J.M. and Agüero, J. The Brucella abortus vaccine strain B19 carries a deletion in the erythritol catabolic genes. FEMS Microbiol. Let. 1994, 121, 337-342.
16. 16 Simon, R., Priefer, U. and Pühler, A. A broad host range mobilization system for in vivo genetic engineering. Transposon mutagenesis Gram negative bacteria. Bio/Technology 1983, 1, 784-791.
17. 17 Kokotek, W. and Lotz, W. Construction of a mobilizable cloning vector for site-directed mutagenesis of Gram-negative bacteria: application to Rhizobium leguminosarum. Gene 1991, 98, 7-13.
18. 18 Pitcher, D.G., Saunders, N.A. and Owen, R.J. Rapid extraction of bacterial genomic DNA with guanidium thiocyanate. Lett. Appl. Microbiol. 1989, 8, 151-156.
19. 19 Sangari, F.J. and Agüero, J. Mutagenesis of Brucella abortus: comparative efficiency of three transposon delivery systems. Microbial Pathogenesis 1991, 11, 443-446.
20. 20 Winter, A.J., Schurig, G.G. and Boyle, S.M. et al. Protection of Balb/c mice against homologous and heterologous species of Brucella by rough strain vaccines derived from Brucella melitensis and Brucella suis biovar 4. Am. J. Vet. Res. 1996, 57, 677-683.
21. 21 Alton, G.G., Jones, L.M., Angus, R.D. and Verger, J.M. Techniques for the Brucellosis Laboratory. Institut National de la Recherche Agronomique (INRA), Paris, 1988.
22. 22 Wong, J.D., Janda, J.M. and Duffey, P.S. Preliminary studies on the use of carbon substrate utilization patterns for identification of Brucella species. Diagn. Microbiol. Infect. Dis. 1992, 15, 1.09-113.
23. 23 Montaraz, J.A. and Winter, A.J. Comparison of living and nonliving vaccines for Brucella abortus in Balb/c mice. Infect. Immun. 1986, 53, 245-251.
24. 24 Bosseray, N. and Plommet, M. Brucella suis S2, Brucella melitensis Rev1 and Brucella abortus S19 living vaccines: residual virulence and immunity induced against three Brucella species challenge strains in mice. Vaccine 1990, 8, 462-468.
25. 25 Bosseray, N. Brucella melitensis Rev1 attenuated vaccine: stability of markers. Residual virulence and immunogenicity in mice. Biologicals 1991, 19, 355-363.
26. 26 Bosseray, N., Plommet, M. and Plommet, A.M. Theoretical, practical and statistical basis for a general control method of activity for antibrucella vaccines. Develop. Biol. Standard. 1984, 56, 257-270.
27. 27 SAS Institute Inc. Language Guide for Personal Computers, Release 6.03. SAS Institute Inc., Cary, NC, 1988.
28. 28 McCullough, N.B. and Beal, G.A. Growth and manometric studies on carbohydrate utilization of Brucella. J. Infect. Dis. 1951, 89, 266-271.
29. 29 Meyer, M.E. Metabolic characterization of the genus Brucella. V. Relationship of strain oxidation rate of i-erythritol to strain virulence for guinea pigs. J. Bacteriol. 1966, 92, 584-588.
30. 30 Tobias, L., Cordes, D.O. and Schurig, G.G. Placental pathology of the pregnant mouse inoculated with Brucella abortus strain 2308. Vet. Pathol. 1993, 30, 119-129.
31. 31 Bosseray, N. Brucella infection and immunity in placenta. Ann. Inst. Pasteur 1987, 138, 110-113.
32. 32 Stevens, M.G., Olsen, S.C., Pugh, G.W. Jr. and Palmer, M.V. Immune and pathologic responses in mice infected with Brucella abortus 19, RB51 or 2308. Infect. Immun. 1994, 62, 3206-3212.
33. 33 Plommet, M. and Plommet, A.M. Virulence of Brucella: bacterial growth and decline in mice. Ann. Res. Vet. 1988, 19, 65-67.
34. 34 Sperry, J.A. and Robertson, D.C. Inhibition of growth by erythritol catabolism in Brucella abortus. J. Bacteriol. 1975, 124, 391-397.
35. 35 Sangari, F.J., Agüero, J. and Garcia-Lobo, J.M. Improvement of the Brucella abortus B19 vaccine by its preparation in a glycerol based medium. Vaccine 1996, 14, 274-276.