Prenatal and perinatal fenarimol-induced genotoxicity in leukocytes of in vivo treated rats

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 583, Issue 1, 2005, Pages 95-104

  De Castro, Vera L S S ^a   De Mello, Michele A ^b   Poli, Paola ^b,c   Zucchi, Tânia M A D ^b  

^a EMBRAPA CERRADOS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF PARMA   (Italy)

Author keywords

Biomarkers; Comet assay; Fenarimol; Genotoxicity; Leukocytes; Rats

Indexed keywords

DNA; FENARIMOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; FEMALE; FETUS; GENOTOXICITY; GESTATIONAL AGE; IN VIVO STUDY; LACTATION; LEUKOCYTE; LITTER SIZE; MILK; NEWBORN; NONHUMAN; PERINATAL DRUG EXPOSURE; PERINATAL PERIOD; PRENATAL EXPOSURE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ANIMALIA;

EID: 18144412381     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2005.02.001     Document Type: Article

References (33)

1. R.A. Ponce, S.M. Bartell, T.J. Kavanagh, J.S. Woods, W.C. Griffith, R.C. Lee, T.K. Takaro, and E.M. Faustman Uncertainty analysis methods for comparing predictive models and biomarkers: a case study of dietary methyl mercury exposure Regul. Toxicol. Pharmacol. 28 1998 96 105
2. A. Collins, M. Dušinská, M. Franklin, M. Somorovská, H. Petrovská, S. Duthie, L. Fillion, M. Panayiotidis, K. Rašlová, and N. Vaughan Comet assay in human biomonitoring studies: reliability, validation, and applications Environ. Mol. Mutagen. 30 1997 139 146
3. K. Hirsch, E. Adams, D. Hoffman, J. Markham, and N. Owen Studies to elucidate the mechanism of fenarimol-induced infertility in male rats Toxicol. Appl. Pharmacol. 86 1986 391 399
4. B. Stoffel-Wagner, M. Watzka, J. Schramm, F. Bidlingmaier, and D. Klingmuller Expression of cyp19 (aromatase) mRNA in different areas of the human brain J. Steroid. Biochem. Mol. Biol. 70 1999 237 241
5. A. Vinggaard, C. Hnida, V. Breinholt, and J. Larsen Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro Toxicol. In Vitro 14 2000 227 234
6. SD. Turner, L. Kragie, T. Ho, CL. Crespi, and DM. Stresser Aromatase inhibition by azole drugs: assessing pregnancy risks Toxicologist 66 1-S 2002 343
7. S.A. Shahin, and K.H. El-Amoodi Induction of numerical chromosomal aberrations during DNA synthesis using the fungicides nimrod and rubigan-4 in root tips of Vicia faba L. Mutat. Res. 261 3 1991 169 176
8. S. Grilli, G. Ancora, P. Rani, A.M. Valenti, M. Mazzullo, and A. Colacci In vivo unwinding fluorimetric assay as evidence of the damage induced by fenarimol and DNOC in rat liver DNA J. Toxicol. Environ. Health 34 1991 485 494
9. D. Palut, J. Ludwick, and J. Szlezak-Kopec The influence of fenarimol on DNA synthesis and mitotic activity in rat liver J. Appl. Toxicol. 12 4 1992 275 279
10. C. Di Ilio, P. Sacchetta, V. Iannarelli, and A. Aceto Binding of pesticides to alpha, mu and pi class glutathione transferase Toxicol. Lett. 76 1995 173 177
11. M. Lodovici, C. Casalini, C. Briani, and P. Dolara Oxidative liver DNA damage in rats treated with pesticide mixtures Toxicology 14 117 1 1997 55 60
12. P. Hrelia, F. Maffei, F. Vigagni, C. Fimognari, P. Flori, R. Stanzani, and G. Cantelli Forti Interactive effects between trichloroethylene and pesticides at metabolic and genetic level in mice Environ. Health Perspect. 102 1994 31 34
13. M. Paolini, R. Mesirca, L. Pozzetti, A. Sapone, and G. Cantelli-Forti Molecular non-genetic biomarkers related to fenarimol cocarcinogenesis: organ- and sex-specific CYP induction in rat Cancer Lett. 101 1996 171 178
14. M. Paolini, R. Mesirca, L. Pozzetti, F. Maffei, F. Vigagni, P. Hrelia, and G. Cantelli-Forti Genetic and non-genetic biomarkers related to carcinogenesis in evaluating toxicological risk from fenarimol Mutat. Res. 368 1996 27 39
15. M. Paolini, L. Pozzetti, R. Mesirca, A. Sapone, and G. Cantelli-Forti Testosterone hydroxylase in evaluating induction and suppression of murine CYP isoenzymes by fenarimol Arch. Toxicol. 70 7 1996 451 456
16. G. Cantelli-Forti, M. Paolini, and P. Hrelia Multiple end point procedure to evaluate risk from pesticides Environ. Health Perspect. 101 1993 15 20
17. P. Poli, M.A. Mello, A. Buschini, V.L. Castro, F. Restivo, C. Rossi, and T.M. Zucchi Evaluation of the genotoxicity induced by the fungicide fenarimol in mammalian and plant cells by use of the single-cell gel electrophoresis assay Mutat. Res. 540 2003 57 66
18. P. Perocco, A. Colacci, and S. Grilli In vitro cell transformation induced by the pesticide fenarimol Res. Commun. Chem. Pathol. Pharmacol. 80 3 1993 345 356
19. S. Cotelle, and J.F. Ferard Comet assay in genetic ecotoxicology: a review Environ. Mol. Mutagen. 34 1999 246 255
20. F. Kassie, W. Parzefall, and S. Knasmuller Single cell gel electrophoresis: a new technique for human biomonitoring studies Mutat. Res. 463 2000 13 31
21. P. Møller, L.E. Knudsen, S. Loft, and H. Wallin The comet assay as a rapid test in biomonitoring occupational exposure to DNA-damaging agents and effect of confounding factors Cancer Epidemiol. Biomark. Prev. 9 2000 1005 1015
22. Y.F. Sasaki, K. Sekihashi, F. Izumiyama, E. Nishidate, A. Saga, K. Ishida, and S. Tsuda The comet assay with multiple mouse organs: comparison of comet assay results and carcinogenicity with 208 chemicals selected from the IARC monographs and U.S. NTP Carcinogenicity Database Crit. Rev. Toxicol. 30 2000 629
23. R.R. Tice, E. Agurell, D. Anderson, B. Burlinson, A. Hartmann, H. Kobayashi, Y. Miyamae, E. Rojas, J.-C. Ryu, and Y.F. Sasaki Single cell gel/Comet assay: guideline for in vitro and in vivo genetic toxicology testing Environ. Mol. Mutagen. 35 2000 206 221
24. A. Hartmann, U. Plappert, F. Poetter, and W. Suter Comparative study with the alkaline Comet assay and the chromosome aberration test Mutat. Res. 20 2003 27 38
25. N.P. Singh, M.T. McCoy, R.R. Tice, and E.L. Schneider A simple technique for quantitation of low levels of DNA damage in individual cells Exp. Cell Res. 175 1988 184 191
26. J. Goodman The traditional toxicologic paradigm is correct: dose influences mechanism Environ. Health Perspect. 106 1998 285 288
27. J. Seiler Pharmacodynamic activity of drugs and ecotoxicology - can the two be connected? Toxicol. Lett. 131 2002 105 115
28. S. Flodstrom, H. Hemming, L. Warngard, and U. Ahlborg Promotion of altered hepatic foci development in rat liver, cytochrome P450 enzyme induction and inhibition of cell-cell communication by DDT and some structurally related organohalogen pesticides Carcinogenesis 11 1990 1413 1417
29. S. Adachi, K. Kawamura, and K. Takemoto Oxidative damage of nuclear DNA in liver of rats exposed to psychological stress Cancer Res. 53 1993 4153 4155
30. H.K. Fischman, R.W. Pero, and D.D. Kelly Psychogenic stress induces chromosomal and DNA damage Int. J. Neurosci. 84 1996 219 227
31. M. Irie, S. Asami, S. Nagata, M. Miyata, and H. Kasai Psychological mediation of a type of oxidative DNA damage, 8-hydroxydeoxyguanosine, in peripheral blood leukocytes of non-smoking and non-drinking workers Psychother. Psychosom. 71 2002 90 96
32. E. Dimitroglou, M. Zafiropoulou, N. Messini-Nikolaki, S. Doudounakis, S. Tsilimigaki, and S.M. Piperakis DNA damage in a human population affected by chronic psychogenic stress Int. J. Hyg. Environ. Health 206 2003 39 44
33. R. Thier, T. Bruning, P.H. Roos, H.P. Rihs, K. Golka, Y. Ko, and H.M. Bolt Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes Int. J. Hyg. Environ. Health 206 3 2003 149 171