Rapid simultaneous determination of metabolic clearance of multiple compounds catalyzed in vitro by recombinant human UDP-glucuronosyltransferases

Analytical Biochemistry

Volumn 341, Issue 1, 2005, Pages 105-112

  Hakala, Kati S ^a   Suchanova, Bohumila ^b   Luukkanen, Leena ^a   Ketola, Raimo A ^a   Finel, Moshe ^a   Kostiainen, Risto ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Charles University in Prague Faculty of Pharmacy   (Czech Republic)

Author keywords

Intrinsic clearance; LC ESI MS MS; n in one cocktails; UDP glucuronosyltransferases

Indexed keywords

CURVE FITTING; DRUG PRODUCTS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM;

EFFECTIVE APPROACHES; INTRINSIC CLEARANCE; LC/ESI/MS/MS; METABOLIC PROPERTIES; SELECTIVE LIQUID CHROMATOGRAPHY; SIMULTANEOUS DETERMINATIONS; SUBSTRATE CONCENTRATIONS; UDP-GLUCURONOSYLTRANSFERASES;

SUBSTRATES;

17BETA ESTRIOL; ENTACAPONE; ESTRIOL; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; HYMECROMONE; PARACETAMOL; QUINOLINOL DERIVATIVE; RECOMBINANT ENZYME; TOLCAPONE; UMBELLIFERONE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ANIMAL CELL; ARTICLE; CATALYST; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME KINETICS; ENZYME SUBSTRATE; INSECT; LIQUID CHROMATOGRAPHY; MICHAELIS CONSTANT; NONHUMAN; OBSERVER VARIATION; PRIORITY JOURNAL; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

EID: 18144409468     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2005.03.003     Document Type: Article

References (18)

1. R.A. Prentis, Y. Lis, and S.R. Walker Pharmaceutical innovation by the seven UK-owned pharmaceutical companies (1964-1985) Br. J. Clin. Pharmacol. 25 1988 387 396
2. D.J. Carlile, A.L. Stevens, E.I.L. Ashforth, D. Waghela, and J.B. Houston In vivo clearance of ethoxycoumarin and its prediction from in vitro systems: Use of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes Drug Metab. Dispos. 26 1998 216 221
3. R.S. Obach, J.B. Baxter, T.E. Liston, B.M. Silber, B.C. Jones, F. Macintyre, D.J. Rance, and P. Wastall Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance J. Pharmacol. Exp. Ther. 200 1997 420 424
4. R.H. Tukey, and C.P. Strassburg Human UDP-glucuronosyltransferases: expression and disease Annu. Rev. Pharmacol. Toxicol. 40 2000 581 616
5. A. Radominska-Pandya, P.J. Czernik, J.M. Little, E. Battaglia, and P.I. Mackenzie Structural and functional studies of UDP-glucuronosyltransferases Drug Metab. Rev. 31 1999 817 899
6. B. Burchell, D.W. Nebert, D.R. Nelson, K.W. Bock, T. Iyanagi, P.L. Jansen, D. Lancet, G.J. Mulder, J.R. Chowdhury, G. Siest, T.R. Tephly, and P.I. Mackenzie The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence DNA Cell Biol. 10 1991 487 494
7. R.H. Tukey, and C.P. Strassburg Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract Mol. Pharmacol. 59 2001 405 414
8. J.S. Janiszewski, K.J. Rogers, K.M. Whalen, M.J. Cole, T.E. Liston, E. Duchoslav, and H.G. Fouda A high-capacity LC/MS system for the bioanalysis of samples generated from plate-based metabolic screening Anal. Chem. 73 2001 1495 1501
9. W.A. Korfmacher, C.A. Palmer, C. Nardo, K. Dunn-Meynell, D. Grotz, K. Cox, C. Lin, C. Elicone, C. Liu, and E. Duchoslav Development of an automated mass spectrometry system for the quantitative analysis of liver microsomal incubation samples: a tool for rapid screening of new compounds for metabolic stability Rapid Commun. Mass Spectrom. 13 1999 901 907
10. P.J. Eddershaw, and M. Dickins Advances in in vitro drug metabolism screening Pharm. Sci. Technol. Today 2 1999 13 19
11. H.Z. Bu, L. Magis, K. Knuth, and P. Teitelbaum High-throughput cytochrome P450 (CYP) inhibition screening via a cassette probe-dosing strategy: VI. Simultaneous evaluation of inhibition potential of drugs on human hepatic isoenzymes CYP2A6, 3A4, 2C9, 2D6, and 2E1 Rapid Commun. Mass Spectrom. 15 2001 741 748
12. S.A. Testino, and G. Patoway High-throughput inhibition screening of major human cytochrome P450 enzymes using an in vitro cocktail and liquid chromatography-tandem mass spectrometry J. Pharm. Biomed. 30 2003 1459 1467
13. K.S. Hakala, L. Laitinen, A.M. Kaukonen, J. Hirvonen, R. Kostiainen, and T. Kotiaho Development of LC/MS/MS for cocktail dosed Caco-2 samples using atmospheric pressure photoionization and electrospray ionization Anal. Chem. 75 2003 5969 5977
14. L. Luukkanen, I. Kilpelaeinen, H. Kangas, P. Ottoila, E. Elovaara, and J. Taskinen Enzyme-assisted synthesis and structural characterization of nitro-chatecol glucuronides Bioconj. Chem. 10 1999 150 154
15. M. Kurkela, J.A. Garcia-Horsman, L. Luukkanen, S. Moersky, J. Taskinen, M. Baumann, R. Kostiainen, J. Hirvonen, and M. Finel Expression and characterization of recombinant human UPD-glucuronosyltransferases (UGTs) J. Biol. Chem. 278 2003 3536 3544
16. T. Kuuranne, M. Kurkela, M. Thevis, W. Schanzer, M. Finel, and R. Kostiainen Glucuronidation of anabolic androgenic steroids by recombinant human UPD-glucuronosyltransferases Drug Metab. Dispos. 31 2003 1117 1124
17. H. Keski-Hynnilä, L. Luukkanen, J. Taskinen, and R. Kostiainen Mass spectrometric and tandem mass spectrometric behavior of nitrocatechol glucuronides: a comparison of atmospheric pressure chemical ionization and electrospray ionization J. Am. Soc. Mass Spectrom. 10 1999 537 545
18. L. Luukkanen, J. Taskinen, M. Kurkela, R. Kostiainen, J. Hirvonen, M. Finel, Kinetic characterization of the 1A subfamily of recombinant human UDP-glucuronosyltransferases, Drug Metab. Dispos. (2005) submitted