Microarray expression profiling of p53-dependent transcriptional changes in an immortalized mouse embryo fibroblast cell line

Cancer Biology and Therapy

Volumn 2, Issue 4, 2003, Pages 416-430

  Sax, Joanna K ^a   Stoddard, Alex ^b   Murphy, Maureen E ^c   Chodosh, Lewis A ^b   El Deiry, Wafik S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c FOX CHASE CANCER CENTER   (United States)

Author keywords

Microarray; p53; Transcription; Tumor suppressor

Indexed keywords

PROTEIN; PROTEIN P53;

ANIMAL; CELL CULTURE; CELL CYCLE; DNA MICROARRAY; EDITORIAL; EMBRYO; FIBROBLAST; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE; NORTHERN BLOTTING; PHYSIOLOGY; TEMPERATURE;

ANIMALS; BLOTTING, NORTHERN; CELL CYCLE; CELLS, CULTURED; EMBRYO; FIBROBLASTS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROTEINS; TEMPERATURE; TUMOR SUPPRESSOR PROTEIN P53;

EID: 18144401901     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.2.4.477     Document Type: Article

References (37)

1. Levine AJ. p53, the cellular gatekeeper for growth and division. Cell 1997; 88:323-31.
2. El-Deiry WS, Tokino T, Velculescu VE, et al. WAF1, a potential mediator of p53 tumor suppression. Cell 1993; 75:817-25. (Pubitemid 23346378)
3. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997; 389:300-5. (Pubitemid 27406646)
4. Schena M, Shalon D, Davis RW, Brown PO. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science 1995; 270:467-70.
5. DeRisi JL, Iyer VR, Brown PO. Exploring the metabolic and genetic control of gene expression on a genomic scale. Science 1997; 278:680-6. (Pubitemid 27464965)
6. Iyer VR, Eisen MB, Ross DT, et al. The transcriptional program in the response of human fibroblasts to serum. Science 1999; 283:83-7. (Pubitemid 29044852)
7. Zhao R, Gish K, Murphy M, et al. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev 2000; 14:981-93. (Pubitemid 30253006)
8. Harvey DM, Levine AJ. p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts. Genes Dev 1991; 5:2375-85. (Pubitemid 21905925)
9. Chen J, Wu X, Lin J, Levine AJ. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol Cell Biol 1996; 16:2445-52. (Pubitemid 26123766)
10. Wu GS, Burns TF, Zhan Y, Alnemri ES, El-Deiry WS. Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis- inducing ligand (TRAIL) death receptor. Cancer Res 1999; 59:2770-5. (Pubitemid 29283105)
11. Somasundaram K, Zhang H, Zeng YX, et al. Arrest of the cell cycle by the tumour-suppressor BRCA1 requires the CDK-inhibitor p21WAF1/CiP1. Nature 1997; 389:187-90. (Pubitemid 27400601)
12. MacLachlan TK, Dash BC, Dicker DT, El-Deiry WS. Repression of BRCA1 through a feedback loop involving p53. J Biol Chem 2000; 275:31869-75.
13. MacLachlan TK, Somasundaram K, Sgagias M, et al. BRCA1 effects on the cell cycle and the DNA damage response are linked to altered gene expression. J Biol Chem 2000; 275:2777-85. (Pubitemid 30082049)
14. Sax JK, Fei P, Murphy ME, Bernhard E, Korsmeyer SJ, El-Deiry WS. BID regulation by p53 contributes to chemosensitivity. Nat Cell Biol 2002; 4:842-9. (Pubitemid 35331358)
15. Juven T, Barak Y, Zauberman A, George DL, Oren M. Wild type p53 can mediate sequence-specific transactivation of an internal promoter within the mdm2 gene. Oncogene 1993; 8:3411-6. (Pubitemid 23342640)
16. Okamoto K, Beach D. Cyclin G is a transcriptional target of the p53 tumor suppressor protein. Embo J 1994; 13:4816-22. (Pubitemid 24319363)
17. Muller M, Wilder S, Bannasch D, et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med 1998; 188:2033-45. (Pubitemid 28562520)
18. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene 1996; 12:1181-7. (Pubitemid 26127248)
19. Gu Z, Flemington C, Chittenden T, Zambetti GP. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol 2000; 20:233-41. (Pubitemid 30002565)
20. Collavin L, Lazarevic D, Utrera R, Marzinotto S, Monte M, Schneider C. wt p53 dependent expression of a membrane-associated isoform of adenylate kinase. Oncogene 1999; 18:5879-88. (Pubitemid 29520444)
21. Miyashita T, Reed JC. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 1995; 80:293-9.
22. Matsumori M, Itoh H, Toyoshima I, et al. Characterization of the 105-kDa molecular chaperone. Identification, biochemical properties, and localization. Eur J Biochem 2002; 269:5632-41. (Pubitemid 35365552)
23. Ozaki H, Watanabe Y, Takahashi K, et al. Six4, a putative myogenin gene regulator, is not essential for mouse embryonal development. Mol Cell Biol 2001; 21:3343-50. (Pubitemid 32381770)
24. Takayama S, Sato T, Krajewski S, et al. Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell 1995; 80:279-84.
25. Squier MK, Miller AC, Malkinson AM, Cohen JJ. Calpain activation in apoptosis. J Cell Physiol 1994; 159:229-37. (Pubitemid 24141929)
26. Arthur JS, Greer PA, Elce JS. Structure of the mouse calpain small subunit gene. Biochim Biophys Acta 1998; 1388:247-52. (Pubitemid 28468624)
27. Wang K, Yin XM, Chao DT, Milliman CL, Korsmeyer SJ. BID: a novel BH3 domain-only death agonist. Genes Dev 1996; 10:2859-69. (Pubitemid 26394246)
28. Schickling O, Stegh AH, Byrd J, Peter ME. Nuclear localization of DEDD leads to caspase- 6 activation through its death effector domain and inhibition of RNA polymerase I dependent transcription. Cell Death Differ 2001; 8:1157-68. (Pubitemid 34048471)
29. Stegh AH, Schickling O, Ehret A, et al. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. Embo J 1998; 17:5974-86. (Pubitemid 28474791)
30. Alcivar A, Hu S, Tang J, Yang X. DEDD and DEDD2 associate with caspase-8/10 and signal cell death. Oncogene 2003; 22:291-7. (Pubitemid 36174186)
31. Bokel C, Brown NH. Integrins in development: moving on, responding to, and sticking to the extracellular matrix. Dev Cell 2002; 3:311-21.
32. Cantor AB, Katz SG, Orkin SH. Distinct domains of the GATA-1 cofactor FOG-1 differentially influence erythroid versus megakaryocytic maturation. Mol Cell Biol 2002; 22:4268-79. (Pubitemid 34556595)
33. Tsang AP, Visvader JE, Turner CA, et al. FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation. Cell 1997; 90:109-19. (Pubitemid 28009423)
34. Sax JK, El-Deiry WS. Identification and characterization of the cytoplasmic protein TRAF4 as a p53 regulated pro-apoptotic gene. J Biol Chem 2003.
35. El-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B. Definition of a consensus binding site for p53. Nat Genet 1992; 1:45-9.
36. Wang L, Wu Q, Qiu P, et al. Analyses of p53 target genes in the human genome by bioinformatic and microarray approaches. J Biol Chem 2001; 276:43604-10.
37. Hoh J, Jin S, Parrado T, Edington J, Levine AJ, Ott J. The p53MH algorithm and its application in detecting p53-responsive genes. Proc Natl Acad Sci U S A 2002; 99:8467-72. (Pubitemid 34693586)