Synonymous mutations in CFTR exon 12 affect splicing and are not neutral in evolution

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 18, 2005, Pages 6368-6372

  Pagani, Franco ^a   Raponi, Michela ^a,b   Baralle, Francisco E ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Composite exonic regulatory elements of splicing; Exonic splicing regulatory sequences; Molecular evolution; Synonymous variations

Indexed keywords

RNA; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ARTICLE; CONTROLLED STUDY; EXON; GENETIC VARIABILITY; HUMAN; HUMAN CELL; MISSENSE MUTATION; MOLECULAR EVOLUTION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA PROCESSING; RNA SPLICING;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; EVOLUTION, MOLECULAR; EXONS; GENE EXPRESSION; HUMANS; MAMMALS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTATION; OLIGONUCLEOTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA SPLICING; SELECTION (GENETICS); SEQUENCE ALIGNMENT; VARIATION (GENETICS);

MAMMALIA;

EID: 18144386947     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0502288102     Document Type: Article

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