Folate targeting of drug carriers: A mathematical model

Journal of Controlled Release

Volumn 104, Issue 1, 2005, Pages 113-128

  Ghaghada, Ketan B ^a,b   Saul, Justin ^d,e   Natarajan, Jayaganesh V ^b,c   Bellamkonda, Ravi V ^d,e   Annapragada, Ananth V ^a,b  

^a University of Houston   (United States)

^b University of Texas School of Health Information Sciences at Houston   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d Emory University   (United States)

^e Case Western Reserve University   (United States)

Author keywords

Carrier cell interactions; Ligand; Ligand bearing carriers; Mathematical model; Receptor; Receptor distribution; Targeted drug delivery; Tethered ligands

Indexed keywords

CELLS; ESTIMATION; MATHEMATICAL MODELS; POLYMERS; TUMORS;

DRUG CARRIERS; FOLATE LIGANDS; LIPOSOMES; POLYMERIC TETHERS;

DRUG PRODUCTS;

DRUG CARRIER; FOLIC ACID;

ACCURACY; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL SURFACE; CONCENTRATION RESPONSE; DRUG DELIVERY SYSTEM; DRUG UPTAKE; EXPOSURE; HUMAN; HUMAN CELL; MATHEMATICAL MODEL; NONHUMAN; PRIORITY JOURNAL; RAT; SURFACE PROPERTY; VALIDATION PROCESS;

EID: 18144380683     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.01.012     Document Type: Article

References (45)

1. D.A. Eavarone, X. Yu, and R.V. Bellamkonda Targeted drug delivery to C6 glioma by transferrin-coupled liposomes J. Biomed. Mater. Res. 51 2000 10 14
2. A. Gabizon, A.T. Horowitz, D. Goren, D. Tzemach, F. Mandelbaum-Shavit, M.M. Qazen, and S. Zalipsky Targeting folate receptor with folate linked to extremities of poly(ethylene glycol)-grafted liposomes: in vitro studies Bioconjug. Chem. 10 1999 289 298
3. A. Kurihara, Y. Deguchi, and W.M. Pardridge Epidermal growth factor radiopharmaceuticals: 111In chelation, conjugation to a blood-brain barrier delivery vector via a biotin-polyethylene linker, pharmacokinetics, and in vivo imaging of experimental brain tumors Bioconjug. Chem. 10 1999 502 511
4. D.A. Lappi Tumor targeting through fibroblast growth factor receptors Semin Cancer Biol. 6 1995 279 288
5. R.J. Lee, and P.S. Low Folate-mediated tumor cell targeting of liposome-entrapped doxorubicin in vitro Biochim. Biophys. Acta 1233 1995 134 144
6. S.K. Bhatia, M.R. King, and D.A. Hammer The state diagram for cell adhesion mediated by two receptors Biophys. J. 84 2003 2671 2690
7. C. Cozens-Roberts, D.A. Lauffenburger, and J.A. Quinn Receptor-mediated cell attachment and detachment kinetics: I. Probabilistic model and analysis Biophys. J. 58 1990 841 856
8. D.A. Hammer, and D.A. Lauffenburger A dynamical model for receptor-mediated cell adhesion to surfaces Biophys. J. 52 1987 475 487
9. C. Zhu Kinetics and mechanics of cell adhesion J. Biomech. 33 2000 23 33
10. D.A. Lauffenburger, and J.J. Linderman Receptors: models for binding, trafficking, and signaling 1993 Oxford University Press New York
11. A.S. Perelson, C. DeLisi, and F.W. Wiegel Cell surface dynamics: concepts and models 1984 Marcel Dekker New York
12. J. Hubble A model of multivalent ligand-receptor equilibria which explains the effect of multivalent binding inhibitors Mol. Immunol. 36 1999 13 18
13. J. Hubble, R. Eisenthal, and W.J. Whish A model for the initial phase of cell/surface interactions based on ligand binding phenomena Biochem. J. 311 1995 917 919
14. W.S. Hlavacek, R.G. Posner, and A.S. Perelson Steric effects on multivalent ligand-receptor binding: exclusion of ligand sites by bound cell surface receptors Biophys. J. 76 1999 3031 3043
15. D.J. Irvine, K.A. Hue, A.M. Mayes, and L.G. Griffith Simulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands Biophys. J. 82 2002 120 132
16. N. Düzgünes, and S. Nir Mechanisms and kinetics of liposome-cell interactions Adv. Drug Deliv. Rev. 40 1999 3 18
17. K.D. Lee, S. Nir, and D. Papahadjopoulos Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes Biochemistry 32 1993 889 899
18. T.J. English, and D.A. Hammer Brownian adhesive dynamics (BRAD) for simulating the receptor-mediated binding of viruses Biophys. J. 86 2004 3359 3372
19. J.M. Saul, A. Annapragada, J.V. Natarajan, and R.V. Bellamkonda Controlled targeting of liposomal doxorubicin via the folate receptor in vitro J. Control. Release 92 2003 49 67
20. M.M. Doucette, and V.L. Stevens Folate receptor function is regulated in response to different cellular growth rates in cultured mammalian cells J. Nutr. 131 2001 2819 2825
21. C. Jeppesen, J.Y. Wong, T.L. Kuhl, J.N. Israelachvili, N. Mullah, S. Zalipsky, and C.M. Marques Impact of polymer tether length on multiple ligand-receptor bond formation Science 293 2001 465 468
22. R.J. Lee, and P.S. Low Delivery of liposomes into cultured KB cells via folate receptor-mediated endocytosis J. Biol. Chem. 269 1994 3198 3204
23. K. Jacobson, and C. Dietrich Looking at lipid rafts? Trends Cell Biol. 9 1999 87 91
24. S. Mayor, and R. Varma GPI-anchored proteins are organized in submicron domains at the cell surface Nature 394 1998 798 801
25. E.D. Sheets, G.M. Lee, R. Simson, and K. Jacobson Transient confinement of a glycosylphosphatidylinositol-anchored protein in the plasma membrane Biochemistry 36 1997 12449 12458
26. S. Sabharanjak, P. Sharma, R.G. Parton, and S. Mayor GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway Dev. Cell Biol. 2 2002 411 423
27. T. Friedrichson, and T.V. Kurzchalia Microdomains of GPI-anchored proteins in living cells revealed by crosslinking Nature 394 1998 802 805
28. J. Wang, W. Gunning, K.M. Kelley, and M. Ratnam Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane J. Membr. Biol. 189 2002 35 43
29. J. Sudimack, R.J. Lee, T. Lee, and W.J. Guo Receptor-specific delivery of liposomes via folate-PEG-Chol J. Liposome Res. 10 2000 179 195
30. W.S. Hlavacek, C. Wofsy, and A.S. Perelson Dissociation of HIV-1 from follicular dendritic cells during HAART: mathematical analysis Proc. Natl. Acad. Sci. U. S. A. 96 1999 14681 14686
31. B.A. Kamen, M.T. Wang, A.J. Streckfuss, X. Peryea, and R.G. Anderson Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles J. Biol. Chem. 263 1988 13602 13609
32. C.P. Leamon, and P.S. Low Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis Proc. Natl. Acad. Sci. U. S. A. 88 1991 5572 5576
33. B.A. Kamen, and A. Capdevila Receptor-mediated folate accumulation is regulated by the cellular folate content Proc. Natl. Acad. Sci. U. S. A. 83 1986 5983 5987
34. S. Mayor, S. Sabharanjak, and F.R. Maxfield Cholesterol-dependent retention of GPI-anchored proteins in endosomes Embo J. 17 1998 4626 4638
35. P.N. Brown, G.D. Byrne, and A.C. Hindmarsh VODE, a variable-coefficient ODE solver SIAM Journal on Scientific and Statistical Computing 10 1989 1038 1051
36. J.A. Reddy, C. Abburi, H. Hofland, S.J. Howard, I. Vlahov, P. Wils, and C.P. Leamon Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors Gene Ther. 9 2002 1542 1550
37. M. McHugh, and Y.C. Cheng Demonstration of a high affinity folate binder in human cell membranes and its characterization in cultured human KB cells J. Biol. Chem. 254 1979 11312 11318
38. J.J. Turek, C.P. Leamon, and P.S. Low Endocytosis of folate-protein conjugates: ultrastructural localization in KB cells J. Cell Sci. 106 1993 423 430
39. O.A. Eniola, P.J. Willcox, and D.A. Hammer Interplay between rolling and firm adhesion elucidated with a cell-free system engineered with two distinct receptor-ligand pairs Biophys. J. 85 2003 2720 2731
40. W.J. Chang, K.G. Rothberg, B.A. Kamen, and R.G. Anderson Lowering the cholesterol content of MA104 cells inhibits receptor-mediated transport of folate J. Cell Biol. 118 1992 63 69
41. A.C. Antony The biological chemistry of folate receptors Blood 79 1992 2807 2820
42. A.C. Antony, Y.S. Tang, R.A. Khan, M.P. Biju, X. Xiao, Q.J. Li, X.L. Sun, H.N. Jayaram, and S.P. Stabler Translational upregulation of folate receptors is mediated by homocysteine via RNA-heterogeneous nuclear ribonucleoprotein E1 interactions J. Clin. Invest. 113 2004 285 301
43. P. Sharma, R. Varma, R.C. Sarasij, Ira, K. Gousset, G. Krishnamoorthy, M. Rao, and S. Mayor Nanoscale organization of multiple GPI-anchored proteins in living cell membranes Cell 116 2004 577 589
44. A. Gabizon, A.T. Horowitz, D. Goren, D. Tzemach, H. Shmeeda, and S. Zalipsky In vivo fate of folate-targeted polyethylene-glycol liposomes in tumor-bearing mice Clin. Cancer Res. 9 2003 6551 6559
45. C.M. Wijmans, and E.B. Zhulina Polymer brushes at curved surfaces Macromolecules 26 1993 7212 7224