Does more aggressive therapy improve outcomes in the treatment of unresectable stage III non-small cell lung cancer?

Seminars in Oncology

Volumn 32, Issue SUPPL. 3, 2005, Pages 13-17

  Rosenman, Julian G ^a,b   Socinski, Mark A ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA HOSPITALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA2B INTERFERON; AMIFOSTINE; CARBOPLATIN; CISPLATIN; DOCETAXEL; ETOPOSIDE; GEFITINIB; IRINOTECAN; NAVELBINE; PACLITAXEL; ANTINEOPLASTIC AGENT; RADIOPROTECTIVE AGENT;

BRONCHUS STENOSIS; CANCER CHEMOTHERAPY; CANCER MORTALITY; CANCER RADIOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; COMPUTER ASSISTED TOMOGRAPHY; CONFERENCE PAPER; DRUG EFFICACY; DRUG INDUCED DISEASE; DRUG TOLERABILITY; ESOPHAGITIS; HEMOPTYSIS; HUMAN; HYPOTHESIS; INTERMETHOD COMPARISON; KIDNEY CARCINOMA; LUNG ASPERGILLOSIS; LUNG NON SMALL CELL CANCER; NEPHRECTOMY; PERICARDIAL EFFUSION; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE; RADIATION DOSE FRACTIONATION; SAFETY; SPINE FRACTURE; TREATMENT OUTCOME; UNITED STATES; UNIVERSITY HOSPITAL; LUNG TUMOR; MULTIMODALITY CANCER THERAPY; REVIEW;

AMIFOSTINE; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CLINICAL TRIALS; COMBINED MODALITY THERAPY; HUMANS; LUNG NEOPLASMS; RADIATION-PROTECTIVE AGENTS; RADIOTHERAPY DOSAGE;

EID: 18144374552     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2005.03.005     Document Type: Conference Paper

References (21)

1. M. Saunders, S. Dische, A. Barrett CHART Steering committee Continuous, hyperfractionated, accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small cell lung cancer Mature data from the randomised multicentre trial Radiother Oncol 52 1999 137 148
2. C. Schaake-Koning, W. Van dan Bogaert, O. Dalesio Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer N Engl J Med 326 1992 524 530
3. K. Furuse, M. Fukuoka, M. Kawahara Phase III study of concurrent versus sequential thoracic radiotherapy in combination with mitomycin, vindesine, and cisplatin in unresectable stage III non-small-cell lung cancer J Clin Oncol 17 1999 2692 2699
4. W.J. Curran Jr, C. Scott, C. Langer Phase III comparison of sequential vs concurrent chemoradiation for PTS with unresected stage III non-small cell lung cancer (NSCLC) Initial report of Radiation Therapy Oncology Group (RTOG) 9410 Proc Am Soc Clin Oncol 19 2000 484a (abstr 615)
5. F. Pierre, P. Maurice, R. Gilles A randomized phase III trial of sequential chemoradiotherapy versus concurrent chemoradiotherapy in locally advanced non-small cell lung cancer (NSCLC) (GLOT-GFPC NPC 95-01 study) Proc Am Soc Clin Oncol 20 2001 312a (abstr 1246)
6. P. Zatloukal, L. Petruzelka, M. Zemanova Concurrent versus sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer A randomized study Lung Cancer 46 2004 87 98
7. R.M. Huber, M. Schmidt, M. Flentje BROCAT-Group Induction chemotherapy and following simultaneous radio/chemotherapy versus induction chemotherapy and radiotherapy alone in inoperable NSCLC (stage IIIa/IIIb) Proc Am Soc Clin Oncol 22 2003 622 (abstr 2501)
8. H. Choy, W.J. Curran Jr, C.B. Scott Preliminary results of locally advanced multimodality protocol (LAMP): ACR 427: A randomized phase II study of three chemoradiation regimens with paclitaxel, carboplatin and thoracic radiation for patients with locally advanced non small cell lung cancer (LA-NSCLC) Proc Am Soc Clin Oncol 21 2002 291 (abstr 1160)
9. R.C. Flanigan, G. Mickisch, R. Sylvester Cytoreductive nephrectomy in patients with metastatic renal cancer A combined analysis J Urol 171 2004 1071 1076
10. W. de Riese, K. Goldenberg, E. Allhoff Metastatic renal cell carcinoma (RCC) Spontaneous regression, long-term survival and late recurrence Int Urol Nephrol 23 1991 13 25
11. D.R. Gandara, K. Chansky, K.S. Albain Southwest Oncology Group Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer Phase II Southwest Oncology Group Study S9504 J Clin Oncol 21 2003 2004 2010
12. E.E. Vokes, J.E. Herndon, M.J. Kelley Induction chemotherapy followed by concomitant chemoradiotherapy (CT/XRT) versus CT/XRT alone for regionally advanced unresectable non-small cell lung cancer (NSCLC) Initial analysis of a randomized phase III trial Proc Am Soc Clin Oncol 23 2004 616 (abstr 7005)
13. D. Rischin, B. Burmeister, P. Mitchell Phase I trial of gefitinib (ZD1839) in combination with concurrent carboplatin, paclitaxel and radiation therapy in patients with stage III non-small cell lung cancer Proc Am Soc Clin Oncol 23 2004 632 (abstr 7077)
14. N. Ready, J. Herndon, E. Vokes Initial cohort toxicity evaluation for chemoradiotherapy (CRT) and ZD1839 in stage III non-small cell lung cancer (NSCLC) A CALGB stratified phase II trial Proc Am Soc Clin Oncol 23 2004 632 (abstr 7078)
15. M.P. Mehta, W. Wang, D. Johnson Induction chemotherapy followed by standard thoracic radiotherapy vs. hyperfractionated accelerated radiotherapy in patients with unresectable stage IIIA and B non-small-cell lung cancer Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597) Int J Radiat Oncol Biol Phys 57 suppl 2 2003 S141 (abstr)
16. C.A. Perez, T.F. Pajak, P. Rubin Long-term observations of the patterns of failure in patients with unresectable non-oat cell carcinoma of the lung treated with definitive radiotherapy. Report by the Radiation Therapy Oncology Group Cancer 59 1987 1874 1881
17. J.G. Rosenman, J.S. Halle, M.A. Socinski High-dose conformal radiotherapy for treatment of stage IIIA/IIIB non-small-cell lung cancer Technical issues and results of a phase I/II trial Int J Radiat Oncol Biol Phys 54 2002 348 356
18. L.B. Marks, J. Garst, M.A. Socinski Carboplatin/paclitaxel or carboplatin/vinorelbine followed by accelerated hyperfractionated conformal radiation therapy Report of a prospective phase I dose escalation trial from the Carolina conformal therapy consortium J Clin Oncol 22 2004 4329 4340
19. M.A. Socinski, D.E. Morris, J.S. Halle Induction and concurrent chemotherapy with high-dose thoracic conformal radiation therapy in unresectable stage IIIA and IIIB non-small-cell lung cancer A dose-escalation phase I trial J Clin Oncol 22 2004 4341 4350
20. J.D. Bradley, C.A. Perez, F. Dehdashti Implementing biological target volumes in radiation treatment planning for non-small cell lung cancer J Nucl Med 45 suppl 1 2004 96S 101S
21. G. Antoch, J. Stattaus, A.T. Nemat Non-small cell lung cancer Dual-modality PET/CT in preoperative staging Radiology 229 2003 526 533