Variability in human sensitivity to 1,3-butadiene: Influence of polymorphisms in the 5′-flanking region of the microsomal epoxide hydrolase gene (EPHX1)

Toxicological Sciences

Volumn 85, Issue 1, 2005, Pages 624-631

  Abdel Rahman, Sherif Z ^a   Ammenheuser, Marinel M ^a   Omiecinski, Curtis J ^b   Wickliffe, Jeffrey K ^a   Rosenblatt, Judah I ^a   Ward Jr , Jonathan B ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Biomarkers; Biomonitoring; Butadiene; EPHX1; Epoxide hydrolase; Genetic susceptibility; HPRT; Polymorphism

Indexed keywords

1,3 BUTADIENE; ARGININE; BIOLOGICAL MARKER; EPOXIDE HYDROLASE; HISTIDINE; RUBBER; TYROSINE;

ADULT; ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; AUTORADIOGRAPHY; CARCINOGENESIS; CELL ASSAY; CONTROLLED STUDY; CORRELATION ANALYSIS; DETOXIFICATION; DNA FLANKING REGION; ENZYME ACTIVITY; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; GENOTOXICITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; HYPOTHESIS; LYMPHOCYTE; MALE; MUTAGENESIS; OCCUPATIONAL EXPOSURE; PREDICTION; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN POLYMORPHISM; RISK ASSESSMENT; RUBBER INDUSTRY; SENSITIVITY ANALYSIS; STATISTICAL MODEL; STATISTICAL SIGNIFICANCE; UNITED STATES; WILD TYPE;

5' FLANKING REGION; ADULT; AGED; ALLELES; BUTADIENES; EPOXIDE HYDROLASES; GENETIC MARKERS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LINKAGE (GENETICS); LYMPHOCYTES; MIDDLE AGED; MUTAGENS; OCCUPATIONAL EXPOSURE; POLYMORPHISM, GENETIC;

EID: 18144370442     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfi115     Document Type: Article

References (39)

1. Abdel-Rahman, S. Z., Nouraldeen, A. M., Ahmed, A. E. (1994). Molecular interaction of [2,3-14C] acrylonitrile with DNA in gastric tissue of rat. J. Biochem. Toxicol. 9, 191-198.
2. Abdel-Rahman, S. Z., Ammenheuser, M. M., and Ward, J. B., Jr, (2001) Human sensitivity to 1,3-butadiene: Role of microsomal epoxide hydrolase polymorphisms. Carcinogenesis 22, 415-423.
3. Abdel-Rahman, S. Z., El-Zein, R. A., Ammenheuser, M. M., Yang, Z., Stock, T., Morandi, M., and Ward, J. B., Jr. (2003). Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene. Environ. Mol. Mutagen. 41, 140-146.
4. Affatato, A., Wolfe, K. J., Lopez, M. S., Hallberg, C., Anitnenheuser, M. M., and Abdel-Rahman, S. Z. (2004). Effect of XPD/ERCC2 polymorphisms on chromosome aberration frequencies in smokers and on sensitivity to the mutagenic tobacco-specific nitrosamine NNK. Environ. Mol. Mutagen. 44, 65-73.
5. Albertini, R. J., Sram, R. J., Vacek, P. M., Lynch, J., Nicklas, J. A., van Sittert, N. J., Boogaard, P. J., Henderson, R. F., Swenberg, J. A., Tates, A. D., et al. (2003). Biomarkers in Czech workers exposed to 1,3-butadiene: A transitional epidemiologic study. Res. Rep. Health Eff. Inst. 116, 1-141; Discussion 143-162.
6. Ammenheuser, M. M., Au, W. W., Whorton, E. B. J., Belli, J. A., and Ward, J. B., Jr. (1991) Comparison of hprt variant frequencies and chromosome aberration frequencies in lymphocytes from radiotherapy and chemotherapy patients: A prospective study. Environ. Mol. Mutagen. 18, 126-135.
7. Ammenheuser, M. M., Hastings, D. A., Whorton, E. B. J., and Ward, J. B., Jr. (1997). Frequencies of hprt mutant lymphocytes in smokers, non-smokers, and former smokers. Environ. Mol. Mutagen. 30, 131-138.
8. Ammenheuser, M. M., Bechtold, W. E., Abdel-Rahman, S. Z., Rosenblatt, J. I., Hastings-Smith, D. A., and Ward, J. B., Jr. (2001). Assessment of 1,3-butadiene exposure in polymer production workers using hprt mutation in lymphocytes as a biomarker. Environ. Health. Perspect. 109, 1249-1255.
9. Benhamou, S., Reinikainen, M., Bouchardy, C., Dayer, P., and Hirvonen, A. (1998). Association between lung cancer and microsomal epoxide hydrolase genotypes. Cancer Res. 58, 5291-5293.
10. Duell, E. J., Wiencke, J. K., Cheng, T. J., Varkonyi, A., Zuo, Z. F., Ashok, T. D., Mark, E. J., Wain, J. C., Christiani, D. C., and Kelsey, K. T. (2000). Polymorphisms in the DNA repair genes XRCC1 and ERCC2 and biomarkers of DNA damage in human blood mononuclear cells. Carcinogenesis 21, 965-971.
11. Duescher, R. J., and Elfarra, A. A. (1994). Human liver microsomes are efficient catalysts of 1,3-butadiene oxidation: Evidence for major roles by cytochromes P450 2A6 and 2E1. Arch. Biochem. Biophys. 311, 342-349.
12. Hassett, C., Aicher, L., Sidhu, J. S., and Omiecinski C. J. (1994). Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum. Mol. Genet. 3, 421-428.
13. Hassett, C., Lin, J., Carty, C. L., Laurenzana, E. M., and Omiecinski, C. J. (1997). Human hepatic microsomal epoxide hydrolase: Comparative analysis of polymorphic expression. Arch. Biochem. Biophysics 337, 275-283.
14. Hayes, R. B., Xi, L., Bechtold, W. E., Rothman, N., Yao, M., Henderson, R., Zhang, L., Smith, M. T., Zhang, D., Wiemels, J., Dosemeci, M., et al. (1996). hprt mutation frequency among workers exposed to 1,3-butadiene in China. Toxicology 113, 100-105.
15. Hayes, R. B., Zhang, L., Yin, S., Swenberg, J. A., Xi, L., Wiencke, J., Bechtold, W. E., Yao, M., Rothman, N., Haas, R., et al. (2000). Genotoxic markers among butadiene polymer workers in China. Carcinogenesis 21, 55-62.
16. Hou, S. M., Falt, S., Angelini, S., Yang, K., Nyberg, E, Lambert, B., and Hemminki, K. (2002). The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk. Carcinogenesis 23, 599-603.
17. IARC (International Agency for Reasearch on Cancer). (1992). Occupational exposures to mists and vapors from strong inorganic acids and other industrial chemicals. International Agency for Research on Cancer Monographs, Lyon.
18. Jackson, M. A., Stack, F. H., Rice, J. M., and Waters, M. D. (2000). A review of the genetic and related effects of 1,3-butadiene in rodents and humans. Mutat. Res. 463, 181-213.
19. Kitteringham, N. R., Davis, C., Howard, N., Pirmohamed, M., and Park, B. K. (1996). Interindividual and interspecies variation in hepatic microsomal epoxide hydrolase activity: Studies with cis-stilbene oxide, carbamezine 10, 11 -epoxide and naphthalene. J Pharmacol. Exp. Ther. 278, 1018-1027.
20. Lauenzana, E. M., Hassett, C., and Omiecinski, C. J. (1998). Post-transcriptional regulation of human microsomal epoxide hydrolase. Pharmacogenetics 8, 157-167.
21. Lee, W. J., Brennan, P., Boffetta, P., London, S. J., Benhamou, S., Rannug, A., To-Figueras, J., Ingelman-Sundberg, M., Shields, P., Gaspari, L., et al. (2002). Microsomal epoxide hydrolase polymorphisms and lung cancer risk: A quantitative review. Biomarkers 7, 230-241.
22. Liang, S. H., Hassett, C., and Omiecinski, C. J. (2005). Alternative promoters determine tissue-specific expression profiles of the human microsomal epoxide hydrolase gene (EPHX1). Mol. Pharmacol. 67, 1-11.
23. Ma, H., Wood T., Ammenheuser, M. M., Rosenblatt, J. I., and Ward, J. B., Jr. (2000) Molecular analysis of hprt mutant lymphocytes from 1,3-butadiene-exposure of workers, Environ. Mol. Mutagen. 18, 126-135.
24. Melnick, R. L., Huff, J., Chou, B. J., and Miller, R. A. (1990). Carcinogenicity of 1,3-butadiene in C57BL/6XC3H F1 mice at low exposure concentrations. Cancer Res. 50, 6592-6599.
25. Meng, Q., Henderson, R. F., Walker, D. M., Bauer, M. J., Reilly, A. A., and Walker, V. E. (1999). Mutagenicity of the racemic mixtures of butadiene monoepoxide and butadiene diepoxide at the hprt locus of T-lymphocytes following inhalation exposures of female mice and rats. Mutat. Res. 429, 127-140.
26. NTP (National Toxicology Program). (2001). National Toxicology Program, 9th Report on Carcinogens, 1,3-Butadiene CAS No. 106-99-0, U.S. Department of Health and Human Services, Public Health Service.
27. Raaka, S., Hassett, C., and Omiencinski, C. J. (1998) Human microsomal epoxide hydrolase: 5′-flanking region genetic polymorphisms. Carcinogenesis 19, 387-393.
28. Seaton, M. J., Follansbee, M. H., and Bond J. A. (1995). Oxidation of 1,2-epoxy-3-butene to 1,2:3,4-diepoxybutane by cDNA-expressed human cytochromes P450 2E1 and 3A4 and human, mouse and rat liver microsomes. Carcinogenesis 16, 2287-2293.
29. Sturgis, E. M., Zheng, R., Li, L., Castillo, E. J., Eicher, S. A., Chen, M., Strom, S. S., Spitz, M. R., and Wei, Q. (2000). XPD/ERCC2 polymorphisms and risk of head and neck cancer: A case-control analysis. Carcinogenesis 21, 2219-2223.
30. Sram, R. J., Rossner, P., Peltonen, K., Podrazilova, K., Mrackova, G., Demopoulos, N. A., Stephanou, G., Vlachodimitropoulos, D., Darroudi, F., and Tates, A. D. (1998). Chromosomal aberrations, sister-chromatid exchanges, cells with high frequency of SCE, micronuclei and comet assay parameters in 1,3- butadiene-exposed workers. Mutat. Res. 419, 145-154.
31. Swenberg, J. A., Koc, H., Upton, P. B., Georguieva, N., Ranasinghe, A., Walker, V. E., Henderson R. (2001). Using DNA and hemoglobin adducts to improve the risk assessment of butadiene. Chem. Biol. Interact. 135-136, 387-403.
32. Tates, A. D., van Dam, F. J., de Zwart, F. A., Darroudi, F., Natarajan, A. T., Rossner, P., Peterkova, K., Peltonen, K., Demopoulos, N. A., Stephanou, G., et al. (1996). Biological effect monitoring in industrial workers from the Czech Republic exposed to low levels of butadiene. Toxicology 113, 91-99.
33. Van Vunakis, H., Gjika, H. B., and Langone, J. J. (1993). Radioimmunoassay for nicotine and cotinine. In Genetic Changes in Lung Cancer (O'Neill, K. D., Ed.), J. Cell. Biochem. Suppl. 17F, 237-248.
34. Vodicka, P., Kumar, R., Stetina, R., Musak, L., Soucek, P., Haufroid, V., Sasiadek, M., Vodickova, L., Naccarati, A., Sedikova, J., et al. (2004). Markers of individual susceptibility and DNA repair rate in workers exposed to xenobiotics in a tire plant. Environ. Mol. Mutagen. 44, 283-292.
35. Ward, J. B., Jr., Ammenheuser, M. M., Bechtold, W. E., Whorton, E. B. J., and Legator, M. S. (1994). HPRT mutant lymphocyte frequencies in workers at a 1,3-butadiene production plant. Environ. Health Perspect. 102, 79-85.
36. Ward, J. B., Jr., Ammenheuser, M. M., Whorton, E. B. J., Bechtold W. E., Kelsey, K. T., and Legator, M. S. (1996) Biological monitoring for mutagenic effects of occupational exposure to butadiene. Toxicology 113, 84-90.
37. Ward, J. B., Jr., Abdel-Rahman, S. Z., Henderson, R. F., Stock, T. H., Morandi, M., Rosenblatt, J. I., and Ammenheuser, M. M. (2001). Assessment of butadiene exposure in synthetic rubber manufacturing workers in Texas using frequencies of hprt mutant lymphocytes as a biomarker. Chem. Biol. Interact. 135-136, 465-483.
38. Wickliffe, J. K., Ammenheuser, M. M., Salazar, J. J., Abdel-Rahman, S. Z., Hastings-Smith, D. A., Postlethwait, E. M., Lloyd, R. S., and Ward, J. B., Jr. (2003) A model of sensitivity: 1,3-butadiene increases mutant frequencies and genomic damage in mice lacking a functional microsomal epoxide hydrolase gene. Environ. Mol. Mutagen. 42, 106-110.
39. Zhang, L., Hayes, R. B., Guo, W., McHale, C. M., Yin, S., Wiencke, J. K., O'Neill, P. J., Rothman, N., Li, G. L., and Smith, M. T. (2004). Lack of increased genetic damage in 1,3-butadiene-exposed Chinese workers studied in relation to EPHX1 and GST genotypes. Mutat. Res. 558, 63-74.