In vitro degradation of the antimicrobial human peptide HEM-γ 130-146 in plasma analyzed by a validated quantitative LC-MS/MS procedure

Analytical Biochemistry

Volumn 341, Issue 1, 2005, Pages 173-186

  John, Harald ^a   Huynh, Kham Dieu ^a   Hedtmann, Christiane ^a   Walden, Michael ^a   Schulz, Axel ^a   Anspach, Friedrich Birger ^b   Forssmann, Wolf Georg ^a  

^a IPF PHARMACEUTICALS GMBH   (Germany)

^b HAMBURG UNIVERSITY OF APPLIED SCIENCES   (Germany)

Author keywords

Aminopeptidases; Antimicrobials; CD13; Hemoglobin ; LC MS MS; Peptide quantification; Plasma enzymes

Indexed keywords

AMINO ACIDS; BIODEGRADATION; CALIBRATION; ELECTROSPRAY IONIZATION; MASS SPECTROMETERS; MICROORGANISMS; PEPTIDES; PHASE SEPARATION; PRECIPITATION (CHEMICAL);

AMINOPEPTIDASES; ANTIMICROBIALS; CD13; LC-MS/MS; PEPTIDE QUANTIFICATION;

PLASMA STABILITY;

MICROSOMAL AMINOPEPTIDASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEINASE INHIBITOR; TRYPTOPHAN; TRYPTOPHYLGLUTAMINYLLYSYLMETHIONYLVALYLTHREONYLALANYLVALYLALANYLSERYL ALANYLLEUCYLSERYLSERYLARGINYLTYROSYLHISTIDINE; UNCLASSIFIED DRUG;

ACCURACY; AMINO TERMINAL SEQUENCE; ARTICLE; CALIBRATION; DRUG DEGRADATION; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; IN VITRO STUDY; INCUBATION TIME; ION TRAP MASS SPECTROMETRY; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PRECIPITATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; QUANTITATIVE ANALYSIS; REPRODUCIBILITY; SEPARATION TECHNIQUE; VALIDATION PROCESS;

ANIMALIA;

EID: 18144363244     PISSN: 00032697     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ab.2005.03.025     Document Type: Article

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