Amination of Grignard reagents with retention of configuration

Organic Letters

Volumn 3, Issue 12, 2001, Pages 1945-1947

  Hoffmann, Reinhard W ^a   Hölzer, Bettina ^a   Knopff, Oliver ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

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EID: 18044403549     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol0160248     Document Type: Article

References (26)

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5. (e) Erdik, E.; Ay, M. Chem. Rev. 1989, 89, 1947-1980.
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13. 3
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15. A referee drew our attention to the Ph.D. Thesis of William H. Pearson, University of Wisconsin, 1982. This thesis contains data which document that the amination of norbornyl-MgBr and of a cyclopropyl-MgBr bv 1 proceed with retention of configuration.
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23. 4), and concentrated. Chromatography as under (1) furnished 7 (26 mg, 69%) of 90% ee.
24. Hoffmann, R. W.; Nell, P. G. Angew. Chem. 1999, 111, 354-355; Angew. Chem., Int. Ed. 1999, 38, 338-340. Hoffmann, R. W.; Nell, P. G.; Leo, R.; Harms, K. Chem. Eur. J. 2000, 6, 3359-3365.
25. Hoffmann, R. W.; Nell, P. G. Angew. Chem. 1999, 111, 354-355; Angew. Chem., Int. Ed. 1999, 38, 338-340. Hoffmann, R. W.; Nell, P. G.; Leo, R.; Harms, K. Chem. Eur. J. 2000, 6, 3359-3365.
26. Hoffmann, R. W.; Nell, P. G. Angew. Chem. 1999, 111, 354-355; Angew. Chem., Int. Ed. 1999, 38, 338-340. Hoffmann, R. W.; Nell, P. G.; Leo, R.; Harms, K. Chem. Eur. J. 2000, 6, 3359-3365.