The parkin gene is not a major susceptibility locus for typical late-onset Parkinson's disease

Neurological Sciences

Volumn 22, Issue 1, 2001, Pages 73-74

  Oliveri, R L ^a,b   Zappia, M ^a,b   Annesi, G ^b   Annesi, F ^b   Spadafora, P ^b   Pasqua, A A ^b   Tomaino, C ^b   Nicoletti, G ^b   Bosco, D ^a   Messina, D ^b   Logroscino, G ^c   Manobianca, G ^c   Epifanio, A ^d   Morgante, L ^d   Savettieri, G ^e   Quattrone, A ^a,b  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b CNR   (Italy)

^c MIULLI GENERAL HOSPITAL   (Italy)

^d UNIVERSITY OF MESSINA   (Italy)

^e UNIVERSITY OF PALERMO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LIGASE; PARKIN; UBIQUITIN PROTEIN LIGASE;

AGED; ARTICLE; CHROMOSOME 6; EXON; FEMALE; GENETIC PREDISPOSITION; GENETIC SCREENING; GENETICS; HUMAN; MALE; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; ONSET AGE; PARKINSONISM; POINT MUTATION; RECESSIVE GENE;

AGE OF ONSET; AGED; CHROMOSOMES, HUMAN, PAIR 6; DNA MUTATIONAL ANALYSIS; EXONS; FEMALE; GENES, RECESSIVE; GENETIC PREDISPOSITION TO DISEASE; GENETIC SCREENING; HUMANS; LIGASES; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PARKINSONIAN DISORDERS; POINT MUTATION; UBIQUITIN-PROTEIN LIGASES;

EID: 18044399423     PISSN: 15901874     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100720170053     Document Type: Article

References (7)

1. Kitada T, Asakawa S, Hattori N et al (1998) Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392:605-608
2. Lücking CB, Dürr A, Bonifati V et al (2000) Association between early-onset Parkinson's disease and mutations in the parkin gene. N Engl J Med 342:1560-1567
3. Hayashi S, Wakabayashi K, Ishikawa A et al (2000) An autopsy case of autosomal-recessive juvenile parkinsonism with a homozygous exon 4 deletion in the parkin gene. Mov Disord 15:884-888
4. Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181-184
5. Hattori N, Kitada T, Matsumine H et al (1998) Molecular genetic analysis of a novel parkin gene in Japanese families with autosomal recessive juvenile parkinsonism: evidence for variable homozygous deletions in the parkin gene in affected individuals. Ann Neurol 44:935-941
6. Golbe LI (1991) Young-onset Parkinson's disease: a clinical review. Neurology 41:168-173
7. Abbas N, Lücking CB, Ricard S et al (1999) A wide variety of mutations in the parkin gene are responsible for autosomal recessive parkinsonism in Europe. Hum Mol Genet 8:567-574