Topical Benzocaine (Hurricaine®) induced methemoglobinemia during endoscopic procedures in gastric bypass patients

Obesity Surgery

Volumn 15, Issue 4, 2005, Pages 584-590

  Srikanth, Myur S ^a,b   Kahlstrom, Richard ^c   Oh, Ki H ^c   Fox, S Ross ^a,b   Fox, Earl R ^a,b   Fox, Katherine M ^a,b  

^a Surgical Weight Loss Clinic   (Mexico)

^b St Francis Hospital   (United States)

^c NONE

Author keywords

Benzocaine; Cyanosis; Desaturation; Endoscopy; Gastric bypass; Methemoglobinemia

Indexed keywords

ASCORBIC ACID; BENZOCAINE; BENZOCAINE PLUS RESORCINOL; METHYLENE BLUE; METOCLOPRAMIDE; RESORCINOL; UNCLASSIFIED DRUG; VAGISIL;

ABDOMINAL PAIN; ADULT; ARTERIAL GAS; ARTICLE; CASE REPORT; CYANOSIS; DEEP VEIN THROMBOSIS; DIARRHEA; DRUG ABSORPTION; DYSPNEA; ESOPHAGOGASTRODUODENOSCOPY; FEMALE; FEVER; GASTRIC BANDING; HUMAN; JEJUNUM ULCER; LUNG EMBOLISM; METHEMOGLOBINEMIA; MORBID OBESITY; NAUSEA AND VOMITING; OXYGEN DISSOCIATION CURVE; PRIORITY JOURNAL; PULSE OXIMETRY; TACHYCARDIA; TREMOR; VAGINAL PRURITUS;

ADMINISTRATION, TOPICAL; ADULT; ANESTHETICS, LOCAL; BENZOCAINE; BODY MASS INDEX; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; GASTRIC BYPASS; HUMANS; INFUSIONS, INTRAVENOUS; LAPAROSCOPY; METHEMOGLOBINEMIA; METHYLENE BLUE; OBESITY, MORBID; OXYGEN; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 18044397837     PISSN: 09608923     EISSN: None     Source Type: Journal    
DOI: 10.1381/0960892053723376     Document Type: Article

References (24)

1. Wright RO, Lewander WJ, Woolf AD. Methemoglobinemia: etiology, pharmacology and clinical management. Ann Emerg Med 1999; 34: 646-56.
2. Khan NA, Kruse JA: Methemoglobinemia induced by topical anesthesia: A case report and review. Am J Med Sci 1999; 318: 415-8.
3. Beutler E. Disorders of hemoglobin. In: Fauci AS, Braunwald E, Isselbacher KJ et al, eds. Harrison's Priniciples of Internal Medicine, edn 14. New York: McGraw-Hill 1998: 645-52.
4. Darling R, Roughton F. The effect of methemoglobin on the equilibrium between oxygen and hemoglobin. Am J Physiol 1942; 137: 56.
5. Misra H, Fridorich I. The generation of superoxide radical during the autooxidation of hemoglobin. J Biol Chem 1972; 247: 6960-2.
6. Eder H, Finch C, McKee R. Congenital methemoglobinemia. A clinical and biochemical study of a case. J Clin Invest 1949; 28: 265-72.
7. Jaffe E, Neumann G. A comparison of the effect of mendione, methylene blue, and ascorbic acid on the reduction of methemoglobin in vivo. Nature 1964; 202: 607-8.
8. Douglas WW, Fairbanks VF. Methemoglobinemia induced by a topical anesthetic (Cetacaine). Chest 1977; 71: 587-91.
9. Ferraro-Borgida MJ, Mulhern SA, DeMeo MO et al. Methemoglobinemia from perineal application of an anesthetic cream. Ann Emerg Med 1996; 27: 785-8.
10. Linden CH, Lovejoy FH Jr. Poisoning and drug overdose. In: Fauci AS, Braunwald E, Isselbacher KJ et al, eds. Harrison's Priniciples of Internal Medicine, edn 14. New York: McGraw-Hill 1998: 645-52.
11. Scott, E, McGraw, J. Purification and properties of diphosphopyridine nucleotide diaphorase of human erythrocytes. J Biol Chem 1962; 237: 249-52.
12. Passon, P, Hultquist, D. Soluble cytochrome b5 reductase from human erythrocytes. Biochem Biophys Acta 1972; 275: 62-73.
13. Kuma F, Ishizawa S, Hirayama K et al. Studies on methemoglobin reductase. I. Comparative studies of diaphorases from normal and methemoglobinemic erythrocytes. J Biol Chem 1972; 247: 550-5.
14. Kiese M. Die reduktion des hamiglobins. Biochem Z 1944; 316: 264-94.
15. Warburg O, Kubowitz F, Christian W. Uber die katalytische wirkung von methylenblau in lebenden zellen. Biochem Z 1930; 227:245-71.
16. Yubishi T, Takeshita M, Yoneyama Y. Reduction of methemoglobin through flavin at the physiologic concentration by the NADPH-flavin reductase of human erythrocytes. J Biochem (Tokyo) 1980; 87:1715-20.
17. Sass M, Caruso C, Farhangi M. TPNH-methemoglobin reductase deficiency. A new red cell enzyme defect. J Lab Clin Med 1967; 70: 760-7.
18. Wendell R, Bunn HF. Hemolytic anemias and acute blood loss. In: Fauci AS, Braunwald E, Isselbacher KJ et al, eds. Harrison's Priniciples of Internal Medicine, edn 14. New York: McGraw-Hill 1998: 659-71.
19. Scott EM, Hoskins DD. Hereditary methemoglobinemia in Alaskan Eskimos and Indians. Blood 1958; 13: 795-802.
20. Mathews PJ: Co-oximetry. Resp Care Clin North Am 1995; 1: 47-68.
21. Kelner M, Bailey D. Mismeasurement of methemoglobin (methemoglobin revisited). Clin Chem 1985; 31: 168-9.
22. Carrodeguas L, Szomstein S, Jacobs J et al. Topical anesthesia-induced methemoglobinemia in bariatric surgical patients. Obes Surg 2005; 15: 282-5.
23. Watcha MF, Connor MT, Hing AV. Pulse oximetry in methemoglobinemia. Am J Dis Child 1989; 143: 845-7.
24. Barker SJ, Tremper KK, Hyatt J. Effects of methemoglobinemia on pulse oximetry and mixed venous oximetry. Anesthesiology 1989; 70: 112-7.